DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and dclk1a

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_005172728.1	Gene:	dclk1a / 558997	ZFINID:	ZDB-GENE-061013-124	Length:	770	Species:	Danio rerio

Alignment Length:	330	Identity:	126/330 - (38%)
Similarity:	181/330 - (54%)	Gaps:	10/330 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL 68
            |...:..||.|.:...:|.|.|::|..||:.||...:|.||||..|...:: ..::.|..|.|::
Zfish   373 PTVPSSISDRYKVGRMIGDGNFAVVHECVEHSTDRAYALKIINKGKCRGKE-HMIQNEVAILRRV 436

  Fly    69 HHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 133
            .|||||.|.:.:...|..|||.:||.||:||:.|.:...|:|.|||..:..:..::.:.|...:|
Zfish   437 KHPNIVLLIEEMDTYNELYLVMELVKGGDLFDAITSANRYTERDASGMLYNLASAIKYLHSLNIV 501

  Fly   134 HRDLKPENLLLASKAKGA-AVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 197
            |||:||||||:.....|: ::||.|||||..|.|   ..:...|||.|::||::.:..||..|||
Zfish   502 HRDIKPENLLVYEHQDGSKSLKLGDFGLATVVDG---PLYTVCGTPTYVAPEIIAETGYGLKVDI 563

  Fly   198 WACGVILYILLVGYPPF--WDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260
            ||.|||.||||.|:|||  ..|||..|:.||..|..::|.|.||.|:..||.||..||.|..::|
Zfish   564 WAAGVITYILLCGFPPFRGSTEDQEALFDQILLGQLEFPLPYWDNVSDSAKELIVSMLQVEVDQR 628

  Fly   261 ITAAEALKHPWICQRERVASVVHRQETVDCLKK-FNARRKLKGAILTTMLATRNFSSRSMITKKG 324
            .||.:.|:|||: ..:.::...|:......:|| ||...|.....:|.|..|. ......|.::|
Zfish   629 YTALQVLEHPWV-TNDGLSENEHQLSVAGKIKKHFNTGPKPNTPGVTVMTTTA-LDKERQILRRG 691

  Fly   325 EGSQV 329
            ....|
Zfish   692 RHQNV 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	118/294 (40%)
		S_TKc	14..272	CDD:214567	110/260 (42%)
		CaMKII_AD	390..517	CDD:285524
dclk1a	XP_005172728.1	DCX	46..137	CDD:214711
		DCX	174..262	CDD:214711
		STKc_DCKL1	376..643	CDD:271085	113/271 (42%)
		S_TKc	383..640	CDD:214567	110/260 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920