DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and camk1a

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_021332939.1	Gene:	camk1a / 555945	ZFINID:	ZDB-GENE-131120-147	Length:	394	Species:	Danio rerio

Alignment Length:	371	Identity:	138/371 - (37%)
Similarity:	207/371 - (55%)	Gaps:	26/371 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPN 72
            |...:|||.||.||.||||.|....:|.|....|.|.|..|.|..:: ..:|.|..:..::.|.|
Zfish    15 TDIKENYDFKEVLGTGAFSEVFLAEEKKTQRLVAIKCIPKKALEGKE-NSIENEIAVLHRIKHEN 78

  Fly    73 IVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDL 137
            ||.|.|..:.:::.|||..||:|||||:.||.:.||:|.|||..|:|||::|.:.|..|:|||||
Zfish    79 IVSLEDIFESQSHLYLVMQLVSGGELFDRIVEKGFYTERDASKLIRQILDAVKYLHDMGIVHRDL 143

  Fly   138 KPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGV 202
            ||||||..|..:.:.:.::||||: :::..........|||||::||||.::||.|:||.|:.||
Zfish   144 KPENLLYYSMEEDSNIMISDFGLS-KIEDSGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGV 207

  Fly   203 ILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEAL 267
            |.||||.|||||:||:..:|:.||....|::.||.||.::..||:.|:.::..:|:.|.|..:||
Zfish   208 ISYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFISHLMEKDPSLRYTCEQAL 272

  Fly   268 KHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEG-SQVKE 331
            .||||.....:...:|...:....|.| |:.|.|.|...|  |......|..::...|| ||:..
Zfish   273 LHPWISGDTALDKNIHESVSAQIKKNF-AKSKWKQAFNAT--AVVRHMRRLQLSTSLEGPSQITS 334

  Fly   332 ST------------DSSSTTLEDDDIKED--------KKGTVDRST 357
            ::            |......|:::.:|:        ::|:.||.:
Zfish   335 TSPYRHLLLPAKELDQRDEEEEEEEEEEENGSPSVDGRRGSADRDS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	123/290 (42%)
		S_TKc	14..272	CDD:214567	114/257 (44%)
		CaMKII_AD	390..517	CDD:285524
camk1a	XP_021332939.1	STKc_CaMKI	17..276	CDD:270985	114/260 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920