DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and camk2a

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001017741.2	Gene:	camk2a / 550436	ZFINID:	ZDB-GENE-051113-72	Length:	478	Species:	Danio rerio

Alignment Length:	515	Identity:	366/515 - (71%)
Similarity:	425/515 - (82%)	Gaps:	45/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 APAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRK 67
            |...||||::.|.:.|||||||||:|:|||:..:|.|:||||||||||:.||.|||:|||||||.
Zfish     2 ATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLSGQEYAAKIINTKKLSTRDHQKLDREARICRL 66

  Fly    68 LHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGV 132
            |.|||||||||||.||.:|||:|||||||||||||||||:|||||||||||||||:|.||||.||
Zfish    67 LKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGV 131

  Fly   133 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 197
            |||||||||||||||:||||||||||||||||:|:.||||||||||||||.|||:|:||||:||:
Zfish   132 VHRDLKPENLLLASKSKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSLEVLRKDPYGKAVDL 196

  Fly   198 WACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRIT 262
            ||||||||||||||||||||||||||.||||||||:|||||||||||||:|||:|||:||:||||
Zfish   197 WACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRIT 261

  Fly   263 AAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFS-SRSMITKKGEG 326
            ||||||||||..|..|||.:||||||:|||||||||||||||||||||||||| .:|.::||.:|
Zfish   262 AAEALKHPWISHRSTVASCMHRQETVECLKKFNARRKLKGAILTTMLATRNFSGGKSGVSKKTDG 326

  Fly   327 SQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSAARR 391
              ||||::|::||:||:|.:                                          .|:
Zfish   327 --VKESSESTNTTIEDEDTR------------------------------------------VRK 347

  Fly   392 QEIIKITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINT 456
            |||||:||||||||::|||:.|||:|||.:||||||||||||||:|||:|||||:..||.|.::|
Zfish   348 QEIIKVTEQLIEAISNGDFESYTKMCDPSVTAFEPEALGNLVEGLDFHRFYFENLWSKNSKPVHT 412

  Fly   457 TILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSAS 516
            ||||||:||:|||||||||:|:|||:|..|...|.||||||:||::|.|||.||||||.|
Zfish   413 TILNPHIHLIGEEAACIAYIRITQYLDNNGMPCTAQSEETRIWHRKDGKWQIVHFHRSGS 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	241/290 (83%)
		S_TKc	14..272	CDD:214567	217/257 (84%)
		CaMKII_AD	390..517	CDD:285524	92/127 (72%)
camk2a	NP_001017741.2	STKc_CaMKII	11..302	CDD:270988	241/290 (83%)
		S_TKc	13..271	CDD:214567	217/257 (84%)
		CaMKII_AD	346..473	CDD:285524	92/127 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	475	1.000	Domainoid score	I413
eggNOG	1	0.900	-	-		E1_KOG0033
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	783	1.000	Inparanoid score	I501
OMA	1	1.010	-	-		QHG52374
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000706
OrthoInspector	1	1.000	-	-		otm25459
orthoMCL	1	0.900	-	-		OOG6_100515
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840