DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and camk1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001016269.1	Gene:	camk1 / 549023	XenbaseID:	XB-GENE-1017139	Length:	383	Species:	Xenopus tropicalis

Alignment Length:	382	Identity:	136/382 - (35%)
Similarity:	204/382 - (53%)	Gaps:	21/382 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRL 76
            |.|:.:|.||.||||.|....:|.|....|.|.|..|.|..:: ..:|.|..:.||:.|.|||.|
Frog    19 DIYEFREVLGTGAFSEVVLAEEKKTQKLVAIKCIPKKALEGKE-TSIENEIAVLRKIKHANIVSL 82

  Fly    77 HDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPEN 141
            .|..:..::.||:..||:|||||:.||.:.||:|.|||..|:|||::|.:.|..|:|||||||||
Frog    83 EDIYESRSHLYLIMQLVSGGELFDRIVEKGFYTEKDASQLIKQILDAVKYLHDMGIVHRDLKPEN 147

  Fly   142 LLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI 206
            ||..|..:.:.:.::||||: :::|.........|||||::||||.::||.|:||.|:.|||.||
Frog   148 LLYYSIDEDSKIMISDFGLS-KIEGSGSVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYI 211

  Fly   207 LLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW 271
            ||.|||||:||:..:|:.||....|::.||.||.::..||:.|..::..:||||.|..:||:|||
Frog   212 LLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIQHLMEKDPNKRNTCDQALQHPW 276

  Fly   272 ICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSS 336
            |.....:...:|...:....|.| |:.:.|.|...|.:.......:...:::|.|.....|....
Frog   277 IAGDTALDKNIHESVSEQIRKNF-AKSRWKQAFNATAVVRHMRKLQLGTSQEGPGQTTPTSPCHG 340

  Fly   337 STTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQN---IGNSQCSSAAR 390
            :..:..|:               .....|..:..|..|:.:.|   .....|:.:.|
Frog   341 NLLMPGDN---------------HGSHSESCQDCCSPKSSENNSLAYSTQHCAQSNR 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	124/290 (43%)
		S_TKc	14..272	CDD:214567	116/257 (45%)
		CaMKII_AD	390..517	CDD:285524	1/1 (100%)
camk1	NP_001016269.1	STKc_CaMKI_alpha	17..279	CDD:271069	119/261 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920