Protein Alignment CaMKII and MYLK

DIOPT Version :9

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_024309300.1
• Gene: MYLK / 4638
• HGNCID: 7590
• Length: 1924
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 149/508 - (29%)
• Similarity: 249/508 - (49%)
• Gaps: 73/508 - (14%)

  Fly     9 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
            :.||.|||:|.||.|.|..|.|.|:|.|...:|.|..  |..:|::.:.:.:|..|...||||.:
Human  1469 KVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFF--KAYSAKEKENIRQEISIMNCLHHPKL 1531

  Fly    74 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCI---QQILESVNHCHQNGVVHR 135
            |:..|:.:|:....:|.::|:||||||.|:..:|  |.....||   :||.|.|.:.|:.|:||.
Human  1532 VQCVDAFEEKANIVMVLEIVSGGELFERIIDEDF--ELTERECIKYMRQISEGVEYIHKQGIVHL 1594

  Fly   136 DLKPENLLLASKAKGAAVKLADFGLA--IEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIW 198
            ||||||::..:|. |..:||.|||||  :|..|..:..|   |||.:::|||:..||.|.:.|:|
Human  1595 DLKPENIMCVNKT-GTRIKLIDFGLARRLENAGSLKVLF---GTPEFVAPEVINYEPIGYATDMW 1655

  Fly   199 ACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITA 263
            :.|||.|||:.|..||..::.:...:.:.:..:|:....:|.::.:||:.|:.:|..:...|:..
Human  1656 SIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDC 1720

  Fly   264 AEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLK--GAILTTMLATRNFSSRSMITKKGEG 326
            .:.|:|||:.:..:  ::..::.:.|.:||:.||||.:  |   ..:.|....||.:||:..
Human  1721 TQCLQHPWLMKDTK--NMEAKKLSKDRMKKYMARRKWQKTG---NAVRAIGRLSSMAMISGL--- 1777

  Fly   327 SQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSAARR 391
            |..|.||.|.::.|..:.::.::..:......|..::|.       .|.|        .|...|.
Human  1778 SGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPH-------VKPY--------FSKTIRD 1827

  Fly   392 QEIIKITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFE---------NVL 447
            .|:::.:....:.    ..:||.   ||.:..|:.:.  ::.|...|...|.|         :|.
Human  1828 LEVVEGSAARFDC----KIEGYP---DPEVVWFKDDQ--SIRESRHFQIDYDEDGNCSLIISDVC 1883

  Fly   448 GKN-----CKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEE 495
            |.:     |||:|:         || ||.|.|  .|.....::|.....:.||
Human  1884 GDDDAKYTCKAVNS---------LG-EATCTA--ELIVETMEEGEGEGEEEEE 1924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	104/297 (35%)
		S_TKc	14..272	CDD:214567	95/262 (36%)
		CaMKII_AD	390..517	CDD:285524	27/120 (23%)
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352
		Ig8_hMLCK_like	1248..1345	CDD:143239
		FN3	1341..1433	CDD:238020
		STKc_MLCK1	1471..1729	CDD:271093	97/265 (37%)
		I-set	1819..1909	CDD:254352	26/118 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920