DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and camk2d2

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_009304932.1	Gene:	camk2d2 / 436815	ZFINID:	ZDB-GENE-040718-277	Length:	554	Species:	Danio rerio

Alignment Length:	549	Identity:	379/549 - (69%)
Similarity:	443/549 - (80%)	Gaps:	39/549 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHP 71
            ||||:|.|.:.|||||||||:|:|||:.|:|.|:||||||||||:|||.|||||||||||.|.||
Zfish     6 CTRFTDEYQLFEELGKGAFSVVRRCVKISSGQEYAAKIINTKKLSARDHQKLEREARICRLLKHP 70

  Fly    72 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRD 136
            |||||||||.||.:|||||||||||||||||||||:|||||||||||||||||:|||.||:||||
Zfish    71 NIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVHHCHVNGIVHRD 135

  Fly   137 LKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACG 201
            |||||||||||.|||||||||||||||||||.||||||||||||||||||:|:||||.||:||||
Zfish   136 LKPENLLLASKMKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACG 200

  Fly   202 VILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEA 266
            ||||||||||||||||||||||.||||||||:|||||||||||||:|||:|||:||:||||||||
Zfish   201 VILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEA 265

  Fly   267 LKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFS-SRSMITKKGEGSQV- 329
            |||||||||..|||::||||||:||||||||||||||||||:|.||||| ::|::.||.:|.:|
Zfish   266 LKHPWICQRSTVASMMHRQETVECLKKFNARRKLKGAILTTLLVTRNFSAAKSLLNKKPDGVKVN 330

  Fly   330 --------------------------------KESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSK 362
                                            ||||:|::||:||:|:|..:.|.:..::.....
Zfish   331 NKTNLASSPKDTGPAPALEPQTTVIHNPVDRNKESTESANTTIEDEDLKARRFGNLSINSIWQPS 395

  Fly   363 --EPEDIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTAFE 425
              .|::..   |.:....::...|..:.||:|||||:||||||:||:|||:.|.|||||.||:||
Zfish   396 VGRPQNSE---PKQAPNSSVQTCQVINKARKQEIIKVTEQLIESINNGDFEAYAKICDPGLTSFE 457

  Fly   426 PEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHT 490
            ||||||||||.|||:|||||.|.|..|.::|.:|||||||:||:||||||:|||||:|..|...|
Zfish   458 PEALGNLVEGHDFHRFYFENALSKGNKPVHTILLNPHVHLIGEDAACIAYIRLTQYMDGSGMPRT 522

  Fly   491 HQSEETRVWHKRDNKWQNVHFHRSASAKI 519
            .|||||||||:||.||.|:|||||.:..:
Zfish   523 MQSEETRVWHRRDGKWLNIHFHRSGAPSV 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		S_TKc	14..272	CDD:214567	224/257 (87%)
		CaMKII_AD	390..517	CDD:285524	91/126 (72%)
camk2d2	XP_009304932.1	STKc_CaMKII	11..302	CDD:270988	251/290 (87%)
		S_TKc	13..271	CDD:214567	224/257 (87%)
		CaMKII_AD	422..549	CDD:285524	91/126 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583926
Domainoid	1	1.000	475	1.000	Domainoid score	I413
eggNOG	1	0.900	-	-		E1_KOG0033
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	783	1.000	Inparanoid score	I501
OMA	1	1.010	-	-		QHG52374
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000706
OrthoInspector	1	1.000	-	-		otm25046
orthoMCL	1	0.900	-	-		OOG6_100515
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3212
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800