DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and camk1gb

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_021325441.1	Gene:	camk1gb / 393802	ZFINID:	ZDB-GENE-040426-1694	Length:	486	Species:	Danio rerio

Alignment Length:	424	Identity:	152/424 - (35%)
Similarity:	223/424 - (52%)	Gaps:	47/424 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRL 76
            |.:|..:.||.||||.|....::.||..||.|.:  ||...||. .||.|..:.||:.|.|:|.|
Zfish    72 DVFDFMDVLGSGAFSEVFMVKERKTGKLFAMKCV--KKKNKRDI-NLENEIAVLRKIKHENVVCL 133

  Fly    77 HDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPEN 141
            .|..:...::|||..||:|||||:.|:.|..|||.|||..|:|:||:|::.|.||:|||||||||
Zfish   134 EDFYESRTHYYLVMQLVSGGELFDRILDRGMYSEMDASSVIRQVLEAVSYLHNNGIVHRDLKPEN 198

  Fly   142 LLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI 206
            ||..|..:.:.:.::||||:  ...|:.......|||||::||||.::||.|:||.|:.|||.||
Zfish   199 LLYYSPDENSKIMISDFGLS--KMEDNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYI 261

  Fly   207 LLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPW 271
            ||.|||||::|.:.||:|:|..|.|::.||.||.::..||:.|..|:..||..|....:||:|||
Zfish   262 LLCGYPPFYEETETRLFSKIMKGQYEFDSPFWDDISESAKDFIRNMMQKNPKMRFNTEQALRHPW 326

  Fly   272 ICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSS 336
            |..:...:..::...:....|.| |:.|.|.|...|:....        .||     ::::...:
Zfish   327 IIGKTARSQDIYHSVSEQMQKNF-AKSKWKQAFNATVAINH--------MKK-----LQQAHSEA 377

  Fly   337 STTLEDD--DIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIG-NSQCSSAARRQE----- 393
            ...|:|.  |:.|.|        .:.|..||.:|....::|.:.|.. |..|.|...:.:
Zfish   378 CVRLKDSPRDVPEIK--------VIASSTPESVRKKLLSETPEPNGSMNVPCGSTEAKSQYHPMR 434

  Fly   394 ----------IIKITEQLIEAINS--GDFDGYTK 415
                      .:.|.|:.....:|  .|.:||.|
Zfish   435 VSHSETTHVGTLTIAEKGKHVYHSEPADLNGYAK 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	127/290 (44%)
		S_TKc	14..272	CDD:214567	119/257 (46%)
		CaMKII_AD	390..517	CDD:285524	7/43 (16%)
camk1gb	XP_021325441.1	PKc_like	70..353	CDD:328722	125/286 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920