DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Dclk3

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001178729.1	Gene:	Dclk3 / 316023	RGDID:	1309232	Length:	807	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	116/291 - (39%)
Similarity:	177/291 - (60%)	Gaps:	8/291 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLH 77
            :|||...:|.|.|:|||.|..:.|...:|.|||:..:|..:: ..::.|..|.:.|.|||||:||
  Rat   514 HYDIGRVIGDGNFAIVKECKHRETRQAYAMKIIDKSQLKGKE-DIVDSEILIIQSLSHPNIVKLH 577

  Fly    78 DSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENL 142
            :..:.|...||:.:.|.||:||:.|:....:.|.||:..|..:.:::.|.|...:||||||||||
  Rat   578 EVYETEAEIYLIMEYVQGGDLFDAIIESVKFPEPDAAVMITDLCKALVHMHDKKIVHRDLKPENL 642

  Fly   143 LL-ASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI 206
            |: .::.|...:||||||||..|.   :..|...|||.|::||:|.::.||..||:||.||||||
  Rat   643 LVQRNEDKSTTLKLADFGLAKHVV---RPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI 704

  Fly   207 LLVGYPPFW--DEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH 269
            ||.|:|||.  :.||..|::.|:.|.:::.||.||.::..||:|:..:|.|:|.||.||.:.|.|
  Rat   705 LLCGFPPFRSPERDQDELFNIIQLGQFEFLSPYWDNISDAAKDLVRNLLVVDPKKRYTAHQVLHH 769

  Fly   270 PWICQRERVASV-VHRQETVDCLKKFNARRK 299
            |||......::| ..::|:.....:|.::.|
  Rat   770 PWIGMVGHPSTVNPQKEESPSSEGRFQSQHK 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	116/291 (40%)
		S_TKc	14..272	CDD:214567	110/260 (42%)
		CaMKII_AD	390..517	CDD:285524
Dclk3	NP_001178729.1	UBQ	92..177	CDD:294102
		PKc_like	514..771	CDD:304357	109/260 (42%)
		S_TKc	515..772	CDD:214567	110/260 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920