DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Camk1d

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001100835.1	Gene:	Camk1d / 307124	RGDID:	1560691	Length:	385	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	135/344 - (39%)
Similarity:	202/344 - (58%)	Gaps:	14/344 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLHD 78
            ::.||.||.||||.|....:|:||..||.|.|..|.|..:: ..:|.|..:.||:.|.|||.|.|
  Rat    23 FEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKE-SSIENEIAVLRKIKHENIVALED 86

  Fly    79 SIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLL 143
            ..:..|:.|||..||:|||||:.||.:.||:|.|||..|:|:|::|.:.|:.|:|||||||||||
  Rat    87 IYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLL 151

  Fly   144 LASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYILL 208
            ..|:.:.:.:.::||||: :::|.........|||||::||||.::||.|:||.|:.|||.||||
  Rat   152 YYSQDEESKIMISDFGLS-KMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILL 215

  Fly   209 VGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWIC 273
            .|||||:||:..:|:.||....|::.||.||.::..||:.|..::..:||||.|..:|.:||||.
  Rat   216 CGYPPFYDENDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIA 280

  Fly   274 QRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSSST 338
            ....::..:|...:....|.| |:.|.:.|...|           .:.:.....|:..|.|||:.
  Rat   281 GDTALSKNIHESVSAQIRKNF-AKSKWRQAFNAT-----------AVVRHMRRLQLGSSLDSSNA 333

  Fly   339 TLEDDDIKEDKKGTVDRST 357
            ::..:.....:|..:..||
  Rat   334 SVSSNLSLASQKDCLAPST 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	125/288 (43%)
		S_TKc	14..272	CDD:214567	118/257 (46%)
		CaMKII_AD	390..517	CDD:285524
Camk1d	NP_001100835.1	STKc_CaMKI_delta	12..312	CDD:271070	126/291 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920