DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Pnck

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_006229634.1	Gene:	Pnck / 29660	RGDID:	69249	Length:	346	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	135/337 - (40%)
Similarity:	202/337 - (59%)	Gaps:	29/337 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 75
            |..|:|:|:||.||||.|....::.:....|.|.|..|.|..:: ..:|.|..:.|::.|||||.
  Rat    15 SSVYEIREKLGSGAFSEVMLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNIVA 78

  Fly    76 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPE 140
            |.|..:..::.||..:||||||||:.|:.|..|:|.||||.:.|:|.:|::.|..|:||||||||
  Rat    79 LEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPE 143

  Fly   141 NLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFA-GTPGYLSPEVLKKEPYGKSVDIWACGVIL 204
            |||.|:..:.:.:.::||||: ::|..:.  .|.| |||||::||:|:::||||:||:||.|||.
  Rat   144 NLLYATPFEDSKIMVSDFGLS-KIQAGNM--LGTACGTPGYVAPELLEQKPYGKAVDVWALGVIS 205

  Fly   205 YILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH 269
            ||||.|||||:||....|:|||...:|::.||.||.::..||:.|..:|..:|.||.|..:||:|
  Rat   206 YILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALQH 270

  Fly   270 PWI-----CQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSM---ITKKGEG 326
            .||     ..|:.:.||..:      ::|..||...|          |.|::.|.   |.|.|:.
  Rat   271 LWISGDAALDRDILGSVSEQ------IQKNFARTHWK----------RAFNATSFLRHIRKLGQS 319

  Fly   327 SQVKESTDSSST 338
            .:.:|::....|
  Rat   320 PEGEEASRQGMT 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	126/296 (43%)
		S_TKc	14..272	CDD:214567	117/258 (45%)
		CaMKII_AD	390..517	CDD:285524
Pnck	XP_006229634.1	STKc_CaMKI_beta	14..290	CDD:271071	123/278 (44%)
Pnck	XP_006229634.1	S_TKc	18..273	CDD:214567	117/258 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920