DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKII and Phkg1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_113761.1	Gene:	Phkg1 / 29353	RGDID:	3325	Length:	388	Species:	Rattus norvegicus

Alignment Length:	317	Identity:	114/317 - (35%)
Similarity:	176/317 - (55%)	Gaps:	29/317 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTK---KLTARDFQKLE----REARICRK 67
            |.:||:.||.||:|..|:|:||:.|.|..|:|.|||:..   ..::.:.|:|.    :|..|.:|
  Rat    16 FYENYEPKEILGRGVSSVVRRCIHKPTCQEYAVKIIDITGGGSFSSEEVQELREATLKEVDILQK 80

  Fly    68 LH-HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 131
            :. ||||::|.|:.:...:.:|||||:..||||:.:..:...:|.:....::.:||.|...|:..
  Rat    81 VSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLTEKETRKIMRALLEVVCTLHKLN 145

  Fly   132 VVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK------KEP 190
            :|||||||||:||.....   :||.|||.:.::|...:. ....|||.||:||:::      ...
  Rat   146 IVHRDLKPENILLDDNMN---IKLTDFGFSCQLQPGEKL-REVCGTPSYLAPEIIQCSMDEGHPG 206

  Fly   191 YGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTV 255
            |||.||:|:.|||:|.||.|.||||...|..:...|..|.|.:.|||||..:...|:|:::.|.|
  Rat   207 YGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMDGKYQFGSPEWDDYSDTVKDLVSRFLVV 271

  Fly   256 NPNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR 312
            .|..|.:|.|||.||:.           ::..|:.::.|:.|.|.|...||.:.:.|
  Rat   272 QPQDRCSAEEALAHPFF-----------QEYVVEEVRHFSPRGKFKVICLTVLASVR 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	110/304 (36%)
		S_TKc	14..272	CDD:214567	104/271 (38%)
		CaMKII_AD	390..517	CDD:285524
Phkg1	NP_113761.1	PKc_like	16..291	CDD:419665	106/289 (37%)
		Calmodulin-binding (domain-N)	303..327		5/15 (33%)
		Calmodulin-binding (domain-C)	343..367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920