Protein Alignment CaMKII and Mylk

DIOPT Version :9

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001099344.2
• Gene: Mylk / 288057
• RGDID: 1310915
• Length: 1961
• Species: Rattus norvegicus
• Alignment Length: 508
• Identity: 148/508 - (29%)
• Similarity: 251/508 - (49%)
• Gaps: 71/508 - (13%)

  Fly     9 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
            :.||.|||:|.||.|.|..|.|.|:|.||..:|.|..  |..:|::.:.:.:|..|...||||.:
  Rat  1502 KVSDVYDIEERLGSGKFGQVFRLVEKRTGKIWAGKFF--KAYSAKEKENIRQEISIMNCLHHPKL 1564

  Fly    74 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCI---QQILESVNHCHQNGVVHR 135
            |:..|:.:|:....:|.::|:||||||.|:..:|  |.....||   :||.|.|.:.|:.|:||.
  Rat  1565 VQCVDAFEEKANIVMVLEIVSGGELFERIIDEDF--ELTERECIKYMRQISEGVEYIHKQGIVHL 1627

  Fly   136 DLKPENLLLASKAKGAAVKLADFGLA--IEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIW 198
            ||||||::..:|. |..:||.|||||  :|..|..:..|   |||.:::|||:..||.|.:.|:|
  Rat  1628 DLKPENIMCVNKT-GTRIKLIDFGLARRLENAGSLKVLF---GTPEFVAPEVINYEPIGYATDMW 1688

  Fly   199 ACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITA 263
            :.|||.|||:.|..||..::.:...:.:.:..:|:....:|.::.:||:.|:.:|..:...|:..
  Rat  1689 SIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISEDAKDFISNLLKKDMKNRLDC 1753

  Fly   264 AEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLK--GAILTTMLATRNFSSRSMITKKGEG 326
            .:.|:|||:.:..:  ::..::.:.|.:||:.||||.:  |   ..:.|....||.:||:..
  Rat  1754 TQCLQHPWLMKDTK--NMEAKKLSKDRMKKYMARRKWQKTG---NAVRAIGRLSSMAMISGL--- 1810

  Fly   327 SQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSAARR 391
            |..|.||.|.::.:..:.::.::..:......|..::|.       .|.|        .|...|.
  Rat  1811 SGRKSSTGSPTSPINAEKLESEEDVSQAFLEAVAEEKPH-------VKPY--------FSKTIRD 1860

  Fly   392 QEIIKITEQLIEAINSGDFDGYTKICDPHLTAFEPEALGNLVEGIDFHKFYFE---------NVL 447
            .|:::.:....:.    ..:||.   ||.:..|:.:.  ::.|...|...|.|         :|.
  Rat  1861 LEVVEGSAARFDC----KIEGYP---DPEVVWFKDDQ--SIRESRHFQIDYDEDGNCSLIISDVC 1916

  Fly   448 GKN-----CKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEE 495
            |.:     |||:|:         || ||.|.|.:.:....:.:|.....:.||
  Rat  1917 GDDDAKYTCKAVNS---------LG-EATCTAELIVETMEEGEGEEGGEEEEE 1959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	105/297 (35%)
		S_TKc	14..272	CDD:214567	96/262 (37%)
		CaMKII_AD	390..517	CDD:285524	26/120 (22%)
Mylk	NP_001099344.2	I-set	42..132	CDD:254352
		Ig	64..129	CDD:143165
		I-set	165..254	CDD:254352
		Ig	183..251	CDD:143165
		23ISL	255..408	CDD:293226
		I-set	410..500	CDD:254352
		Ig	427..497	CDD:143165
		I-set	510..596	CDD:254352
		IGc2	523..586	CDD:197706
		I-set	619..708	CDD:254352
		Ig	636..704	CDD:143165
		I-set	717..805	CDD:254352
		Ig	720..805	CDD:299845
		I-set	1141..1230	CDD:254352
		IGc2	1154..1220	CDD:197706
		Ig	1281..1378	CDD:299845
		I-set	1281..1370	CDD:254352
		FN3	1374..1465	CDD:238020
		STKc_MLCK1	1504..1762	CDD:271093	98/265 (37%)
		Pkinase	1507..1762	CDD:278497	96/262 (37%)
		I-set	1852..1942	CDD:254352	25/116 (22%)
		IGc2	1865..1932	CDD:197706	15/84 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920