Protein Alignment CaMKII and caska

DIOPT Version :10

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_017213110.1
• Gene: caska / 259195
• ZFINID: ZDB-GENE-020802-4
• Length: 965
• Species: Danio rerio
• Alignment Length: 606
• Identity: 191/606 - (31%)
• Similarity: 290/606 - (47%)
• Gaps: 113/606 - (18%)

  Fly    10 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTAR---DFQKLEREARICRKLHHP 71
            |.|.|::.|.:|||.||:|:||:.:.||.:||.||::..|.|:.   ..:.|:|||.||..|.||
Zfish     8 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHP 72

  Fly    72 NIVRLHDSIQEENYHYLVFDLVTGGELFEDIVARE----FYSEADASHCIQQILESVNHCHQNGV 132
            :||.|.::...:...|:||:.:.|.:|..:||.|.    .||||.|||.::||||::.:||.|.:
Zfish    73 HIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNI 137

  Fly   133 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 197
            :|||:||..:|||||...|.|||..||:||::........|..|||.:::|||:|:|||||.||:
Zfish   138 IHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDV 202

  Fly   198 WACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSP-EWDTVTPEAKNLINQMLTVNPNKRI 261
            |.|||||:|||.|..||:. .:.||:..|..|.|...:| :|..::..||:|:.:||.::|.:||
Zfish   203 WGCGVILFILLSGCLPFYG-TKERLFEAIIKGKYKVMNPRQWGHISESAKDLVRRMLMLDPAERI 266

  Fly   262 TAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR-------------N 313
            |..|||.|||:.:|:|.|..:|..|||:.|:|||||||||||:|..:.:.:             :
Zfish   267 TVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPD 331

  Fly   314 FS----SRSMITKKGEGSQVKES-------TDSSSTTL-------EDDDIKE-----DKKGTVDR 355
            ||    |..::..:...|||.:|       ||.|...|       :|..:..     ||..|  :
Zfish   332 FSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDHHLHTLLDLYDKINT--K 394

  Fly   356 STTVVSKEPEDIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTK----- 415
            |:..:.....|      |....:.......||||     :|..|.::|.|:....:...|
Zfish   395 SSPQIRNPSSD------AVQRAKETSTEDGSSAA-----LKHLEYVLEEISCYPENTDAKELRRI 448

  Fly   416 ICDPHLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAA-------CI 473
            :..||..|.           :..|......|...:...:.....:|:::....|:.       .:
Zfish   449 LTQPHFMAL-----------LQTHDVVAHEVYSDDAMRVTPPPTSPYLNGDSPESTNGDMDIENV 502

  Fly   474 AYVRLTQY------------------------------IDKQGHAHTHQSEETRVWHKRDNKWQN 508
            ..|||.|:                              |.:||..|.  .:|.|..:......|.
Zfish   503 TRVRLVQFQKNTDEPMGITLKMNDLNHCIVARIMHGGMIHRQGTLHI--GDEIREINGISVANQT 565

  Fly   509 VHFHRSASAKISGATTFDFIP 529
            |...:....::.|:.||..:|
Zfish   566 VEQLQKMLREMRGSITFKIVP 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	137/298 (46%)
		CaMKII_AD	390..517	CDD:285524	24/168 (14%)
caska	XP_017213110.1	STKc_CASK	8..308	CDD:270996	138/300 (46%)
		L27	349..402	CDD:197794	13/54 (24%)
		L27	429..471	CDD:460717	8/52 (15%)
		PDZ_CASK-like	506..586	CDD:467267	14/81 (17%)
		SH3_CASK	646..707	CDD:213014
		Guanylate_kin	768..950	CDD:395500