DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CaMKII and Camk4

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_036859.2	Gene:	Camk4 / 25050	RGDID:	2264	Length:	474	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	164/457 - (35%)
Similarity:	251/457 - (54%)	Gaps:	62/457 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 75
            ||.::::.|||:||.|||.||.||.|...:|.|::  ||..  |.:.:..|..:..:|.||||::
  Rat    39 SDFFEVESELGRGATSIVYRCKQKGTQKPYALKVL--KKTV--DKKIVRTEIGVLLRLSHPNIIK 99

  Fly    76 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPE 140
            |.:..:......||.:||||||||:.||.:.:|||.||:..::||||:|.:.|:||:||||||||
  Rat   100 LKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPE 164

  Fly   141 NLLLASKAKGAAVKLADFGLAIEVQGDHQAWF-GFAGTPGYLSPEVLKKEPYGKSVDIWACGVIL 204
            |||.|:.|..|.:|:|||||:..|  :||... ...|||||.:||:|:...||..||:|:.|:|.
  Rat   165 NLLYATPAPDAPLKIADFGLSKIV--EHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIIT 227

  Fly   205 YILLVGYPPFWDE--DQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEAL 267
            ||||.|:.||:||  ||. ::.:|....|.:.||.||.|:..||:|:.:::.::|.||:|..:||
  Rat   228 YILLCGFEPFYDERGDQF-MFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQAL 291

  Fly   268 KHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQV--- 329
            :|||:  ..:.|:.||.......|::||||||||.|:...:.::|..|:.|..|...|.::.
  Rat   292 QHPWV--TGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTNIQESNKASSE 354

  Fly   330 -------KESTD------------------------SSSTTLEDDDIKEDKKGTVDRSTT--VVS 361
                   |:.||                        .|....|::.:||:::...:...|  :|.
  Rat   355 AQPAQDGKDKTDPLENKMQAGDHEAAKAAADETMKLQSEEVEEEEGVKEEEEEEEEEEETSRMVP 419

  Fly   362 KEPEDIRILCPAKTYQQNI-GNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTAFE 425
            :|||| |:    :|..|.: .||:.:..:..:|:....|:...|:..|        ..|...|..
  Rat   420 QEPED-RL----ETDDQEMKRNSEETLKSVEEEMDPKAEEEAAAVGLG--------VPPQQDAIL 471

  Fly   426 PE 427
            ||
  Rat   472 PE 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	131/293 (45%)
		S_TKc	14..272	CDD:214567	117/260 (45%)
		CaMKII_AD	390..517	CDD:285524	8/38 (21%)
Camk4	NP_036859.2	STKc_CaMKIV	38..331	CDD:270987	133/300 (44%)
		Autoinhibitory domain	297..336		14/38 (37%)
		PP2A-binding. /evidence=ECO:0000250	302..319		5/16 (31%)
		Calmodulin-binding. /evidence=ECO:0000255	318..337		8/18 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..474		30/151 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920