DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Dclk3

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_766516.2	Gene:	Dclk3 / 245038	MGIID:	3039580	Length:	790	Species:	Mus musculus

Alignment Length:	263	Identity:	109/263 - (41%)
Similarity:	165/263 - (62%)	Gaps:	7/263 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVRLH 77
            :|||...:|.|.|:.||.|..:.|...:|.|:|:..:|..:: ..::.|..|.:.|.|||||:||
Mouse   513 HYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKE-DIVDSEILIIQSLSHPNIVKLH 576

  Fly    78 DSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPENL 142
            :..:.|...||:.:.|.||:||:.||....:.|.:|:..|..:.:::.|.|...:||||:|||||
Mouse   577 EVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENL 641

  Fly   143 LL-ASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI 206
            |: .::.|...:||||||||..|.   :..|...|||.|::||:|.::.||..||:||.||||||
Mouse   642 LVQRNEDKSITLKLADFGLAKYVV---RPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI 703

  Fly   207 LLVGYPPFW--DEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH 269
            ||.|:|||.  :.||..|::.|:.|.:::.||.||.::..||:|:..:|.|:|.||.||.:.|:|
Mouse   704 LLCGFPPFRSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNLLEVDPKKRYTAEQVLQH 768

  Fly   270 PWI 272
            |||
Mouse   769 PWI 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	109/263 (41%)
		S_TKc	14..272	CDD:214567	107/260 (41%)
		CaMKII_AD	390..517	CDD:285524
Dclk3	NP_766516.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		UBQ	92..177	CDD:294102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..290
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..506
		PKc_like	513..770	CDD:304357	106/260 (41%)
		S_TKc	514..771	CDD:214567	107/260 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920