DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Pskh1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_775608.1	Gene:	Pskh1 / 244631	MGIID:	3528383	Length:	424	Species:	Mus musculus

Alignment Length:	343	Identity:	128/343 - (37%)
Similarity:	196/343 - (57%)	Gaps:	26/343 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
            |.:..||||..:|:|:||.|.|...::|...:|.|:|.||....|:.  .|.|.|:.|::.|.||
Mouse    93 RVTAKYDIKALIGRGSFSRVVRVEHRATRQPYAIKMIETKYREGREV--CESELRVLRRVRHANI 155

  Fly    74 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLK 138
            ::|.:..:.:...|:|.:|.||||||:.|:|:..::|.||:..:|.:|:.|.:.|..|:.|||||
Mouse   156 IQLVEVFETQERVYMVMELATGGELFDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLK 220

  Fly   139 PENLLLASKAKGAAVKLADFGLA-IEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGV 202
            |||||.......:.:.:.||||| ...:||........|||.|::||||.::||..|||:||.||
Mouse   221 PENLLYYHPGTDSKIIITDFGLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGV 285

  Fly   203 ILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEAL 267
            |.||||.|..||.|:::.|||.||..|.|.|....|.:|:..||:.|:::|||:|..|:||.:||
Mouse   286 IAYILLSGTMPFEDDNRTRLYRQILRGKYSYLGEPWPSVSNLAKDFIDRLLTVDPGARMTALQAL 350

  Fly   268 KHPWICQRERVASV--VHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVK 330
            :|||:......:|:  :||..:.:.||:                    .|||...||..:.::..
Mouse   351 RHPWVVSMAASSSMKNLHRSISQNLLKR--------------------ASSRCQSTKSSQSTRSS 395

  Fly   331 ESTDSS-STTLEDDDIKE 347
            .||.|: |..:.:.:::|
Mouse   396 RSTRSNKSRRVRERELRE 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	117/293 (40%)
		S_TKc	14..272	CDD:214567	111/258 (43%)
		CaMKII_AD	390..517	CDD:285524
Pskh1	NP_775608.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..79
		STKc_PSKH1	96..355	CDD:270989	111/260 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..408		9/49 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920