Protein Alignment CaMKII and Camk2d

DIOPT Version :10

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_036651.1
• Gene: Camk2d / 24246
• RGDID: 2263
• Length: 533
• Species: Rattus norvegicus
• Alignment Length: 551
• Identity: 384/551 - (69%)
• Similarity: 432/551 - (78%)
• Gaps: 74/551 - (13%)

  Fly     1 MAAPAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARIC 65
            ||:...||||:|.|.:.|||||||||:|:||::..||.|:||||||||||:|||.||||||||||
  Rat     1 MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARIC 65

  Fly    66 RKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQN 130
            |.|.|||||||||||.||.:|||||||||||||||||||||:|||||||||||||||||||||.|
  Rat    66 RLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLN 130

  Fly   131 GVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSV 195
            |:|||||||||||||||:|||||||||||||||||||.||||||||||||||||||:|:||||.|
  Rat   131 GIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPV 195

  Fly   196 DIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260
            |:||||||||||||||||||||||||||.||||||||:|||||||||||||:|||:|||:||.||
  Rat   196 DMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKR 260

  Fly   261 ITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGE 325
            |||:|||||||||||..|||::|||||||||||||||||||||||||||||||||:...:.||.:
  Rat   261 ITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPD 325

  Fly   326 GSQV--------------------------------KESTDSSSTTLEDDDIKEDKKGTVDRSTT 358
            |.::                                ||||:||:||:||:|:|
  Rat   326 GVKINNKANVVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVK------------ 378

  Fly   359 VVSKEPEDIRILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKICDPHLTA 423
                                          ||:|||||:|||||||||:|||:.|||||||.|||
  Rat   379 ------------------------------ARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTA 413

  Fly   424 FEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHA 488
            ||||||||||||:|||:|||||.|.|..|.|:|.||||||||:|::||||||:|||||:|..|..
  Rat   414 FEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGNGMP 478

  Fly   489 HTHQSEETRVWHKRDNKWQNVHFHRSASAKI 519
            .|.|||||||||:||.||||:|||||.|..:
  Rat   479 KTMQSEETRVWHRRDGKWQNIHFHRSGSPTV 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		CaMKII_AD	390..517	CDD:285524	96/126 (76%)
Camk2d	NP_036651.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		Autoinhibitory domain. /evidence=ECO:0000250	283..292		8/8 (100%)
		Calmodulin-binding. /evidence=ECO:0000250	291..301		9/9 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..375		9/37 (24%)
		CaMKII_AD	380..507	CDD:285524	96/126 (76%)