DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Camk1g

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_011237234.1	Gene:	Camk1g / 215303	MGIID:	2388073	Length:	491	Species:	Mus musculus

Alignment Length:	481	Identity:	157/481 - (32%)
Similarity:	226/481 - (46%)	Gaps:	80/481 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPN 72
            |.....:...|.||.||||.|....|:.||..||.|.|  ||..|.....||.|..:.:::.|.|
Mouse    17 TNIRKTFIFMEVLGSGAFSEVFLVKQRVTGKLFALKCI--KKSPAFRDSSLENEIAVLKRIKHEN 79

  Fly    73 IVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDL 137
            ||.|.|..:...::|||..||:|||||:.|:.|..|:|.|||..|||:|.:|.:.|:||:|||||
Mouse    80 IVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDL 144

  Fly   138 KPENLLLASKAKGAAVKLADFGLA-IEVQGDHQAWFGFAGTPGYL--------------SPEVLK 187
            ||||||..:..:.:.:.:.||||: :|..|   ......|||||:              :||||.
Mouse   145 KPENLLYLTPEENSKIMITDFGLSKMEQNG---VMSTACGTPGYVAHREGKSRKDLKKEAPEVLA 206

  Fly   188 KEPYGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQM 252
            ::||.|:||.|:.|||.||||.|||||::|.:.:|:.:||.|.|::.||.||.::..||:.|..:
Mouse   207 QKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFESPFWDDISESAKDFICHL 271

  Fly   253 LTVNPNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR----- 312
            |..:||:|.|..:||:||||.....:...::...::...|.| |:.|.:.|.....:...
Mouse   272 LEKDPNERYTCEKALRHPWIDGNTALHRDIYPSVSLQIQKNF-AKSKWRQAFNAAAVVHHMRKLH 335

  Fly   313 -NFSSRSMITKKGEGSQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVV---------SKEPE-- 365
             |..|.|:..:......|..:.:.|.....|..|.|  ...:|.||.:.         |..|.
Mouse   336 MNLHSPSVRQEVENRPPVSPAPEVSRPDSHDSSITE--APILDPSTPLPALTRLPCSHSSRPSAP 398

  Fly   366 ------------DIRILCPAKTYQQ---------------NIGN----SQCSS-----AARRQEI 394
                        .:||.......||               ||||    |.||.     .|.:::.
Mouse   399 SGGRSLNCLVNGSLRISSSLVPMQQGPLATGPCGCCSSCLNIGNKGKSSYCSEPTLFRKANKKQN 463

  Fly   395 IKITEQLIEAINSGDF---DGYTKIC 417
            .| :|.::.....|..   .|.|.:|
Mouse   464 FK-SEVMVPVKAGGSTHCRGGQTGVC 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	124/305 (41%)
		S_TKc	14..272	CDD:214567	118/272 (43%)
		CaMKII_AD	390..517	CDD:285524	6/31 (19%)
Camk1g	XP_011237234.1	STKc_CaMKI_gamma	19..317	CDD:271068	123/303 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910