DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and chk-2

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001024271.1	Gene:	chk-2 / 180304	WormBaseID:	WBGene00000499	Length:	476	Species:	Caenorhabditis elegans

Alignment Length:	304	Identity:	100/304 - (32%)
Similarity:	154/304 - (50%)	Gaps:	29/304 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLT--------ARDFQKLEREARICRKLHHPNIVRL 76
            ||||.|..|....:||.....|.|.:||:..|        .||   :..|..:.:||.|||||.:
Worm   176 LGKGGFGKVLLGYKKSDRSVVAIKQLNTQFSTRCSRAIAKTRD---IRNEVEVMKKLSHPNIVAI 237

  Fly    77 HDSIQEENYHYLVFDLVTGGELFEDIVAREF----YSEADASHCIQQILESVNHCHQNGVVHRDL 137
            :|.|....|.|:|.:.|.|||.|..:|..::    ..|:...:...|:::::.:.|..|:.|||:
Worm   238 YDWITVAKYSYMVIEYVGGGEFFSKVVDSKYNRMGLGESLGKYFAFQLIDAILYLHSVGICHRDI 302

  Fly   138 KPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKE--PYGKSVDIWAC 200
            ||||:|.:.||:...:||.|||:|   :..........|||.|.:||::..|  .|...||||:.
Worm   303 KPENILCSDKAERCILKLTDFGMA---KNSVNRMKTRCGTPSYNAPEIVANEGVEYTPKVDIWSL 364

  Fly   201 GVILYILLVGYPPFWDE-DQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAA 264
            |.:|:|...|||||.:| ....:..|:..|...:.: :|..:|.|.:|:|..||||.|:.|.:|.
Worm   365 GCVLFITFSGYPPFSEEYTDMTMDEQVLTGRLIFHA-QWRRITVETQNMIKWMLTVEPSNRPSAV 428

  Fly   265 EALKHPWI-CQRERVASVVHRQETVDCLKKFNARRKLKGAILTT 307
            |.:...|: |...|.|    :|:.:..:|..:|  ....|:.||
Worm   429 ELMSTQWMKCADCRTA----KQDILKSIKPISA--AAPAALQTT 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	97/298 (33%)
		S_TKc	14..272	CDD:214567	90/266 (34%)
		CaMKII_AD	390..517	CDD:285524
chk-2	NP_001024271.1	STKc_Chk2	162..436	CDD:270986	90/266 (34%)
chk-2	NP_001024271.1	S_TKc	176..436	CDD:214567	90/266 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910