DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and zyg-8

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_499571.2	Gene:	zyg-8 / 176639	WormBaseID:	WBGene00006993	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	268	Identity:	99/268 - (36%)
Similarity:	149/268 - (55%)	Gaps:	11/268 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DNYDIKEELGKGAFSIVKRCVQKSTGFE-FAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 75
            :.:.:...:|.|..::|...:.|:...: .|.|:|..:.:..:: ..:|.|..|.:|:.|..||:
Worm   480 EKFQLVRLIGDGNTAVVYEVIDKTNNDDRKAMKVIARENVIGKE-HLIEMELAILQKIDHTFIVQ 543

  Fly    76 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASH---CIQQILESVNHCHQNGVVHRDL 137
            |:|....::.:||..:|:..|:|||.:.......|.||..   |:.|.||   :.|:.|:||||:
Worm   544 LYDHWFVDDSYYLSLELIEMGDLFEHLRIVRRVPERDAVRMMTCLGQALE---YIHELGIVHRDV 605

  Fly   138 KPENLLLASKAKG-AAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACG 201
            |.||||:.....| ..|||||||||.|:..|........|||.|::||||.|..||..|||||.|
Worm   606 KLENLLIVKDEFGELGVKLADFGLAAEMPKDFGVLSTICGTPTYVAPEVLNKTGYGCKVDIWAAG 670

  Fly   202 VILYILLVGYPPFWDED--QHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAA 264
            ||||.:|||:|||...|  :..|:|.|.:|.:.:|||.||.|:...::||..::..:|..|.:|.
Worm   671 VILYAILVGFPPFQSSDGSEQDLFSAIMSGEFSFPSPSWDDVSWSVRHLIMCLIHTDPFHRYSAG 735

  Fly   265 EALKHPWI 272
            |.|...|:
Worm   736 ELLNDEWM 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	99/268 (37%)
		S_TKc	14..272	CDD:214567	98/264 (37%)
		CaMKII_AD	390..517	CDD:285524
zyg-8	NP_499571.2	DCX	206..298	CDD:214711
		DCX	335..423	CDD:214711
		STKc_DCKL	481..742	CDD:270997	98/264 (37%)
		S_TKc	482..743	CDD:214567	98/264 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920