DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Phkg2

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_542151.1	Gene:	Phkg2 / 140671	RGDID:	620024	Length:	406	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	135/393 - (34%)
Similarity:	206/393 - (52%)	Gaps:	58/393 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKI--INTKKLTARDFQKL----EREAR 63
            ||...|...||.|:.:|:|..|:|:|||.::||.|||.||  ::.::|:....:::    .||..
  Rat    15 AAAKEFYQKYDPKDIIGRGVSSVVRRCVHRATGDEFAVKIMEVSAERLSLEQLEEVRDATRREMH 79

  Fly    64 ICRKL-HHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHC 127
            |.|:: .||:|:.|.||.:..::.:|||||:..||||:.:..:...||.:....::.:||:||..
  Rat    80 ILRQVAGHPHIITLIDSYESSSFMFLVFDLMRKGELFDYLTEKVALSEKETRSIMRSLLEAVNFL 144

  Fly   128 HQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLK----- 187
            |.|.:|||||||||:||....:   ::|:|||.:..::...:. ....||||||:||:||
  Rat   145 HVNNIVHRDLKPENILLDDNMQ---IRLSDFGFSCHLEPGEKL-RELCGTPGYLAPEILKCSMDE 205

  Fly   188 KEP-YGKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQ 251
            ..| |||.||:|||||||:.||.|.||||...|..:...|..|.|.:.|||||..:...|:||.:
  Rat   206 THPGYGKEVDLWACGVILFTLLAGSPPFWHRRQILMLRMIMEGQYQFSSPEWDDRSNTVKDLIAK 270

  Fly   252 MLTVNPNKRITAAEALKHPWI--CQRERVASVVHRQE------TV-----DCLKKFNARRKLKGA 303
            :|.|:||.|:||.:||:||:.  |:..:..::..||.      |:     ..|.....|...|.|
  Rat   271 LLQVDPNARLTAEQALQHPFFERCKGSQPWNLTPRQRFRVAVWTILAAGRVALSSHRLRPLTKNA 335

  Fly   304 ILTTMLATRNFSSRSMI-----------TKKGEGSQ---------------VKESTDSSSTTLED 342
            :|....|.|  ..|.:|           .||||...               :....:..|:.:.:
  Rat   336 LLRDPYALR--PVRRLIDNCAFRLYGHWVKKGEQQNRAALFQHQPPRPFPIIATDLEGDSSAITE 398

  Fly   343 DDI 345
            |::
  Rat   399 DEV 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	120/316 (38%)
		S_TKc	14..272	CDD:214567	113/270 (42%)
		CaMKII_AD	390..517	CDD:285524
Phkg2	NP_542151.1	STKc_PhKG2	13..291	CDD:271083	116/279 (42%)
		Calmodulin-binding (domain-N). /evidence=ECO:0000250	306..330		3/23 (13%)
		Calmodulin-binding (domain-C). /evidence=ECO:0000250	346..370		6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920