Protein Alignment CaMKII and PNCK

DIOPT Version :10

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001034671.3
• Gene: PNCK / 139728
• HGNCID: 13415
• Length: 426
• Species: Homo sapiens
• Alignment Length: 323
• Identity: 134/323 - (41%)
• Similarity: 196/323 - (60%)
• Gaps: 18/323 - (5%)

  Fly    11 SDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIVR 75
            |..|:|:|.||.||||.|....::.:....|.|.|..|.|..:: ..:|.|..:.|::.|||||.
Human    95 SSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKE-ALVENEIAVLRRISHPNIVA 158

  Fly    76 LHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVVHRDLKPE 140
            |.|..:..::.||..:||||||||:.|:.|..|:|.||||.:.|:|.:|::.|..|:||||||||
Human   159 LEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPE 223

  Fly   141 NLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFA-GTPGYLSPEVLKKEPYGKSVDIWACGVIL 204
            |||.|:..:.:.:.::||||: ::|..:.  .|.| |||||::||:|:::||||:||:||.|||.
Human   224 NLLYATPFEDSKIMVSDFGLS-KIQAGNM--LGTACGTPGYVAPELLEQKPYGKAVDVWALGVIS 285

  Fly   205 YILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKH 269
            ||||.|||||:||....|:|||...:|::.||.||.::..||:.|..:|..:|.||.|..:||:|
Human   286 YILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRH 350

  Fly   270 PWIC-----QRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGS 327
            .||.     .|:.:.||..:      ::|..||...|.|...|.. .|:......| .:|||:
Human   351 LWISGDTAFDRDILGSVSEQ------IRKNFARTHWKRAFNATSF-LRHIRKLGQI-PEGEGA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	126/296 (43%)
		CaMKII_AD	390..517	CDD:285524
PNCK	NP_001034671.3	STKc_CaMKI_beta	94..370	CDD:271071	123/278 (44%)