DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and Dclk1

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_064362.1	Gene:	Dclk1 / 13175	MGIID:	1330861	Length:	756	Species:	Mus musculus

Alignment Length:	359	Identity:	132/359 - (36%)
Similarity:	194/359 - (54%)	Gaps:	30/359 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKL 68
            ||..|   :.|.:...:|.|.|::||.|:::||..|:|.|||...|...:: ..::.|..|.|::
Mouse   399 PATIT---ERYKVGRTIGDGNFAVVKECIERSTAREYALKIIKKSKCRGKE-HMIQNEVSILRRV 459

  Fly    69 HHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGVV 133
            .|||||.|.:.:......|||.:||.||:||:.|.:...|:|.|||..:..:..::.:.|...:|
Mouse   460 KHPNIVLLIEEMDVPTELYLVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIV 524

  Fly   134 HRDLKPENLLLASKAKGA-AVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 197
            |||:||||||:.....|: ::||.|||||..|.|   ..:...|||.|::||::.:..||..|||
Mouse   525 HRDIKPENLLVYEHQDGSKSLKLGDFGLATIVDG---PLYTVCGTPTYVAPEIIAETGYGLKVDI 586

  Fly   198 WACGVILYILLVGYPPF--WDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKR 260
            ||.|||.||||.|:|||  ..:||..|:.||..|..|:|||.||.|:..||.|||.||.||.::|
Mouse   587 WAAGVITYILLCGFPPFRGSGDDQEVLFDQILMGQVDFPSPYWDNVSDSAKELINMMLLVNVDQR 651

  Fly   261 ITAAEALKHPWICQRERVASVVHRQETVDCLKK-FNARRKLKG-AILTTMLATRNFSSRSMITKK 323
            .:|.:.|:|||: ..:.:....|:......:|| ||...|... |...:::||........:.::
Mouse   652 FSAVQVLEHPWV-NDDGLPENEHQLSVAGKIKKHFNTGPKPSSTAAGVSVIATTALDKERQVFRR 715

  Fly   324 GEGSQVK--------------ESTD---SSSTTL 340
            .....|:              ||.|   |||.|:
Mouse   716 RRNQDVRSRYKAQPAPPELNSESEDYSPSSSETV 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	118/295 (40%)
		S_TKc	14..272	CDD:214567	111/260 (43%)
		CaMKII_AD	390..517	CDD:285524
Dclk1	NP_064362.1	DCX	52..142	CDD:214711
		DCX	181..269	CDD:214711
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..393
		STKc_DCKL1	399..666	CDD:271085	115/274 (42%)
		S_TKc	406..663	CDD:214567	111/260 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..756		8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920