Protein Alignment CaMKII and Cask

DIOPT Version :10

• Sequence 1: NP_001162833.1
• Gene: CaMKII / 43828
• FlyBaseID: FBgn0264607
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_011245733.1
• Gene: Cask / 12361
• MGIID: 1309489
• Length: 972
• Species: Mus musculus
• Alignment Length: 593
• Identity: 192/593 - (32%)
• Similarity: 291/593 - (49%)
• Gaps: 98/593 - (16%)

  Fly    10 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTA---------RDFQKLEREARIC 65
            |.|.|::.|.:|||.||:|:||:.:.||.:||.||::..|.|:         |....|:|||.||
Mouse     8 FEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEGKRWISNLKREASIC 72

  Fly    66 RKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVARE----FYSEADASHCIQQILESVNH 126
            ..|.||:||.|.::...:...|:||:.:.|.:|..:||.|.    .||||.|||.::||||::.:
Mouse    73 HMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRY 137

  Fly   127 CHQNGVVHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPY 191
            ||.|.::|||:||..:|||||...|.|||..||:||::........|..|||.:::|||:|:|||
Mouse   138 CHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPY 202

  Fly   192 GKSVDIWACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVN 256
            ||.||:|.|||||:|||.|..||:. .:.||:..|..|.|.....:|..::..||:|:.:||.::
Mouse   203 GKPVDVWGCGVILFILLSGCLPFYG-TKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLD 266

  Fly   257 PNKRITAAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR--------- 312
            |.:|||..|||.|||:.:|:|.|..:|..|||:.|:|||||||||||:|..:.:.:
Mouse   267 PAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPP 331

  Fly   313 ----NFS----SRSMITKKGEGSQVKES-------TDSSSTTL-------EDDDIKE-----DKK 350
                :||    |..::..:...|||.:|       ||.|...|       :|..:..     ||.
Mouse   332 EELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKI 396

  Fly   351 GTVDRSTTVVSKEPEDI-----RILCPAKTYQQNIGNSQCSSAARRQEIIKITEQLIEAINSGDF 410
            .|  :|:..:...|.|.     .:|.....|.:|       :.|:..:.|......:..:.:.|.
Mouse   397 NT--KSSPQIRNPPSDAVQRAKEVLEEISCYPEN-------NDAKELKRILTQPHFMALLQTHDV 452

  Fly   411 DGYTKICD-----------PHLTAFEPE-ALGNL-------VEGIDFHKFYFENVLGKNCKAINT 456
            ..:....|           |:|....|| |.|::       |..:.|.| ..:..:|...|
Mouse   453 VAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQK-NTDEPMGITLK---- 512

  Fly   457 TILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKISG 521
              :|...|.:      :|.:.....|.:||..|.  .:|.|..:......|.|...:....::.|
Mouse   513 --MNELNHCI------VARIMHGGMIHRQGTLHV--GDEIREINGISVANQTVEQLQKMLREMRG 567

  Fly   522 ATTFDFIP 529
            :.||..:|
Mouse   568 SITFKIVP 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	137/303 (45%)
		CaMKII_AD	390..517	CDD:285524	25/145 (17%)
Cask	XP_011245733.1	STKc_CASK	8..313	CDD:270996	138/305 (45%)
		L27	354..407	CDD:197794	13/54 (24%)
		L27	412..462	CDD:460717	7/56 (13%)
		PDZ_CASK-like	495..575	CDD:467267	18/94 (19%)
		SH3_CASK	622..683	CDD:213014
		Guanylate_kin	744..957	CDD:395500