DRSC/TRiP Functional Genomics Resources

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Protein Alignment CaMKII and mylk

DIOPT Version :9

Sequence 1:NP_001162833.1 Gene:CaMKII / 43828 FlyBaseID:FBgn0264607 Length:531 Species:Drosophila melanogaster
Sequence 2:XP_031749515.1 Gene:mylk / 101730432 XenbaseID:XB-GENE-22164540 Length:1969 Species:Xenopus tropicalis


Alignment Length:513 Identity:147/513 - (28%)
Similarity:252/513 - (49%) Gaps:82/513 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 RFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNI 73
            :.:|.||::|.||.|.|..|.|.|:|.:...:|.|..  |..:|:|.:.:.:|..|...||||.:
 Frog  1513 KVTDYYDVEERLGTGKFGQVFRIVEKKSRKIYAGKFF--KAYSAKDKEGIRQEIAIMNCLHHPKL 1575

  Fly    74 VRLHDSIQEENYHYLVFDLVTGGELFEDIVAREF-YSEADASHCIQQILESVNHCHQNGVVHRDL 137
            |:..|:.:.:....:|.:||:||||||.|:..:| .:|.:....::||.|.|...|:.|:||.||
 Frog  1576 VQCVDAFESKADMVMVLELVSGGELFERIIDEDFELTEREVIKYMKQICEGVEFIHKQGIVHLDL 1640

  Fly   138 KPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGV 202
            ||||::..:|. |..:||.|||||..::........| |||.:::|||:..||.|.|.|:|:.||
 Frog  1641 KPENIMCVNKT-GTKIKLIDFGLARRLESCPNLKVLF-GTPEFVAPEVINYEPIGYSTDMWSIGV 1703

  Fly   203 ILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEAL 267
            |.|||:.|..||..::.:...:.:.:..:|:....:|.::.||||||:.:|..:...|:...:.|
 Frog  1704 ICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISEEAKNLISSLLKKDMKNRLNCTQCL 1768

  Fly   268 KHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATR---NFSSRSMIT----KKGE 325
            :|.|:  ::..|::..::.:.|.:||:.||||.:    .|..|.|   ..||.:||:    :|..
 Frog  1769 QHSWL--QQDTATMEAKKLSKDRMKKYMARRKWQ----KTGHAVRAIGRLSSMAMISGLSARKSS 1827

  Fly   326 GSQVKESTDSSSTTLEDDDIKEDKKGTVDRSTTVVSKEPEDIRILCPAKTYQQNIGNSQCSSAAR 390
            |     |..||..:.|.:..:||.:..::   :|..::|       |||.:             .
 Frog  1828 G-----SAPSSPLSAELEANEEDNQAFLE---SVTEEKP-------PAKPF-------------F 1864

  Fly   391 RQEIIKITEQLIEAINSGDFD----GYTKICDPHLTAFEPEALGNLVEGIDFHKFYFEN------ 445
            .:.|:.|  :::|. ::..||    |:.   ||.:..::.:.  .:.|...|...|.|:      
 Frog  1865 TKTILDI--EVVEG-SAARFDCRIEGHP---DPEVIWYKDDQ--PIKESRHFQIDYDEDGNCSLT 1921

  Fly   446 ---VLGKN-----CKAINTTILNPHVHLLGEEAACIAYVRLTQYIDKQGHAHTHQSEE 495
               |.|.:     |||.|:         || :..|.|.:.:....:::......:.||
 Frog  1922 ISEVCGDDDAKYTCKAANS---------LG-DTTCTAELIVEVMAEEEEEEEEEEEEE 1969

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CaMKIINP_001162833.1 STKc_CaMKII 12..303 CDD:270988 103/291 (35%)
S_TKc 14..272 CDD:214567 93/258 (36%)
CaMKII_AD 390..517 CDD:285524 24/124 (19%)
mylkXP_031749515.1 Ig 1865..1952 CDD:416386 22/104 (21%)
Ig strand A 1865..1868 CDD:409353 0/2 (0%)
Ig strand A' 1870..1873 CDD:409353 1/4 (25%)
Ig strand B 1877..1886 CDD:409353 2/8 (25%)
Ig strand C 1891..1897 CDD:409353 1/5 (20%)
Ig strand C' 1900..1902 CDD:409353 0/3 (0%)
Ig strand D 1908..1913 CDD:409353 1/4 (25%)
Ig strand E 1916..1924 CDD:409353 0/7 (0%)
Ig strand F 1932..1939 CDD:409353 3/6 (50%)
Ig strand G 1942..1952 CDD:409353 3/10 (30%)
Ig strand A 255..258 CDD:409353
I-set 256..345 CDD:400151
Ig strand A' 261..265 CDD:409353
Ig strand B 273..281 CDD:409353
Ig strand C 286..291 CDD:409353
Ig strand C' 294..296 CDD:409353
Ig strand D 302..307 CDD:409353
Ig strand E 310..315 CDD:409353
Ig strand F 324..332 CDD:409353
Ig 354..441 CDD:416386
Ig strand A 354..357 CDD:409353
Ig strand A' 363..366 CDD:409353
Ig strand B 371..379 CDD:409353
Ig strand C 385..389 CDD:409353
Ig strand C' 392..395 CDD:409353
Ig strand D 399..403 CDD:409353
Ig strand E 407..412 CDD:409353
Ig strand F 420..428 CDD:409353
Ig strand G 431..441 CDD:409353
Ig 461..550 CDD:416386
Ig strand A 461..464 CDD:409353
Ig strand A' 469..472 CDD:409353
Ig strand B 478..485 CDD:409353
Ig strand C 491..496 CDD:409353
Ig strand C' 499..501 CDD:409353
Ig strand D 506..510 CDD:409353
Ig strand E 516..520 CDD:409353
Ig strand F 529..537 CDD:409353
Ig strand G 540..550 CDD:409353
I-set 559..645 CDD:400151
Ig strand A 562..565 CDD:409353
Ig strand A' 567..571 CDD:409353
Ig strand B 574..583 CDD:409353
Ig strand C 589..594 CDD:409353
Ig strand C' 597..600 CDD:409353
Ig strand D 603..608 CDD:409353
Ig strand E 609..617 CDD:409353
Ig strand F 624..632 CDD:409353
Ig strand G 635..645 CDD:409353
MSCRAMM_ClfA <869..1146 CDD:411231
I-set 1155..1244 CDD:400151
Ig strand A' 1160..1164 CDD:409353
Ig strand B 1172..1180 CDD:409353
Ig strand C 1185..1190 CDD:409353
Ig strand C' 1193..1195 CDD:409353
Ig strand D 1201..1206 CDD:409353
Ig strand E 1209..1214 CDD:409353
Ig strand F 1223..1231 CDD:409353
Ig strand G 1234..1244 CDD:409353
Ig 1291..1388 CDD:416386
Ig strand A 1291..1294 CDD:409353
Ig strand A' 1299..1303 CDD:409353
Ig strand B 1307..1316 CDD:409353
Ig strand C 1320..1326 CDD:409353
Ig strand C' 1329..1331 CDD:409353
Ig strand D 1337..1342 CDD:409353
Ig strand E 1346..1351 CDD:409353
Ig strand F 1359..1367 CDD:409353
Ig strand G 1370..1380 CDD:409353
FN3 1384..1476 CDD:238020
PKc_like 1515..1773 CDD:419665 94/261 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D330091at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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