DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and mylkl

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_002935598.3	Gene:	mylkl / 100489678	XenbaseID:	XB-GENE-923293	Length:	855	Species:	Xenopus tropicalis

Alignment Length:	330	Identity:	110/330 - (33%)
Similarity:	168/330 - (50%)	Gaps:	16/330 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLHHPNIV 74
            |:|.|...|:||.|.|..|.:..::|||...|.|..  |..|.::.|....|..:..|||||.:|
Frog   417 FNDFYIQLEKLGMGKFGQVYKLKERSTGKICAGKFF--KARTQKEIQGARVEVELMNKLHHPQLV 479

  Fly    75 RLHDSIQEENYHYLVFDLVTGGELFEDIVAREF-YSEADASHCIQQILESVNHCHQNGVVHRDLK 138
            |...:.||.....:|.:.:.||||||.|||.:| ::|......|.|||..|.:.|...:||.|||
Frog   480 RCLSAFQEPGRVVMVLEYIAGGELFERIVADDFEHTEVMCVEYICQILNGVAYMHHQSIVHLDLK 544

  Fly   139 PENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVI 203
            |||::..:.... .||:.|||||.|:. .|.......||..:::|||:..||.|.:.|:|:.|||
Frog   545 PENIICLNTVSN-QVKIIDFGLARELD-PHVPMKVLQGTAEFVAPEVIAFEPVGFTTDMWSLGVI 607

  Fly   204 LYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALK 268
            .||||.|..||...:.......|.:..:|:.......::..||:.:.::|..|...|:||.:||.
Frog   608 CYILLSGDSPFQGNNDMETMQNITSACWDFDDETNALLSETAKDFVKRLLQKNMRSRLTAVQALD 672

  Fly   269 HPWICQRERVASVVHRQETV--DCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKE 331
            |||:..:     .|.:.:|:  :.:|||.||:|.:    .|..|....:..::::.|.:.:....
Frog   673 HPWVQHK-----CVSKTKTLSKERIKKFLARQKWQ----KTGKAVLALNRMALLSAKSDNNTTST 728

  Fly   332 STDSS 336
            .||.|
Frog   729 HTDGS 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	103/293 (35%)
		S_TKc	14..272	CDD:214567	93/258 (36%)
		CaMKII_AD	390..517	CDD:285524
mylkl	XP_002935598.3	Ig	207..297	CDD:416386
		Ig strand A'	208..212	CDD:409353
		Ig strand B	216..225	CDD:409353
		Ig strand C	229..235	CDD:409353
		Ig strand C'	238..240	CDD:409353
		Ig strand D	246..251	CDD:409353
		Ig strand E	255..260	CDD:409353
		Ig strand F	268..276	CDD:409353
		Ig strand G	279..289	CDD:409353
		FN3	293..388	CDD:238020
		PKc_like	427..675	CDD:419665	90/251 (36%)
		Ig	757..841	CDD:416386
		Ig strand A'	759..762	CDD:409353
		Ig strand B	766..775	CDD:409353
		Ig strand C	780..786	CDD:409353
		Ig strand C'	789..791	CDD:409353
		Ig strand D	797..802	CDD:409353
		Ig strand E	805..813	CDD:409353
		Ig strand F	821..828	CDD:409353
		Ig strand G	831..841	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920