DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and dclk2

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_012811056.1	Gene:	dclk2 / 100487296	XenbaseID:	XB-GENE-960488	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	273	Identity:	117/273 - (42%)
Similarity:	165/273 - (60%)	Gaps:	13/273 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RFSD------NYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRK 67
            :|:|      .|.|.:.:|.|.|::||.||::|||.|||.|||:..|...:: ..:|.|..|.|:
Frog   387 KFTDASIILEKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKAKCCGKE-HLIENEVSILRQ 450

  Fly    68 LHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGV 132
            :.||||:.|.:.:......|||.:||.||:||:.|.:...|:|.|||..:..:..::.:.|...:
Frog   451 VKHPNIIMLIEEMDTTAELYLVMELVKGGDLFDAITSSTKYTERDASAMVYNLASAMKYLHGLHI 515

  Fly   133 VHRDLKPENLLLAS-KAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVD 196
            ||||:||||||:.. ..|..::||.|||||..|.|   ..:...|||.|::||::.:..||..||
Frog   516 VHRDIKPENLLVCEYPDKTKSLKLGDFGLATVVDG---PLYTVCGTPTYVAPEIIAETGYGLKVD 577

  Fly   197 IWACGVILYILLVGYPPFWDED--QHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNK 259
            |||.|||.||||.|:|||..|:  |..|:.||..|..::|||.||.:|..||.||:.||.||..:
Frog   578 IWAAGVITYILLCGFPPFRSENNLQEDLFDQILIGKLEFPSPYWDNITDSAKELISCMLQVNVEE 642

  Fly   260 RITAAEALKHPWI 272
            |.||.:.|.|||:
Frog   643 RYTAEQILSHPWV 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	116/270 (43%)
		S_TKc	14..272	CDD:214567	114/260 (44%)
		CaMKII_AD	390..517	CDD:285524
dclk2	XP_012811056.1	DCX1_DCLK2	70..154	CDD:340661
		DCX2	193..276	CDD:340589
		STKc_DCKL2	396..654	CDD:271086	113/261 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010