DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CaMKII and camk2d

DIOPT Version :9

Sequence 1:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_017952440.2	Gene:	camk2d / 100135023	XenbaseID:	XB-GENE-868293	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	555	Identity:	390/555 - (70%)
Similarity:	439/555 - (79%)	Gaps:	59/555 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 APAACTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRK 67
            |...||||:|.|.:.|||||||||:|:||::.:||.|:||||||||||:|||.|||||||||||.
Frog     2 ASTTCTRFTDEYQLFEELGKGAFSVVRRCMKITTGQEYAAKIINTKKLSARDHQKLEREARICRL 66

  Fly    68 LHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNGV 132
            |.|||||||||||.||.:|||||||||||||||||||||:|||||||||||||||||||||.||:
Frog    67 LKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGI 131

  Fly   133 VHRDLKPENLLLASKAKGAAVKLADFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDI 197
            |||||||||||||||.|||||||||||||||||||.||||||||||||||||||:|:||||.||:
Frog   132 VHRDLKPENLLLASKLKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDM 196

  Fly   198 WACGVILYILLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVNPNKRIT 262
            ||||||||||||||||||||||||||.||||||||:|||||||||||||:|||:|||:||.||||
Frog   197 WACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRIT 261

  Fly   263 AAEALKHPWICQRERVASVVHRQETVDCLKKFNARRKLKGAILTTMLATRNFSSRSMITKKGEGS 327
            |||||:|||||||..|||::|||||||||||||||||||||||||||||||||:...:.||.:|.
Frog   262 AAEALRHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGV 326

  Fly   328 QV-------------------------------KESTDSSSTTLEDDDIKEDKKGTVDRSTTVVS 361
            ::                               ||||:||:||:||:|:|..|
Frog   327 KINNKANVITSPKDPTPPLEPQSTVIHNPADGNKESTESSNTTIEDEDVKATK------------ 379

  Fly   362 KEPEDIRILCPAKTYQQN-------IGNSQCSSAARRQEIIKITEQLIEAINSGDFDGYTKICDP 419
                     |...||.:.       ..||..|..:|:|||||:|||||||||:|||:.|||||||
Frog   380 ---------CTENTYSKTHLHESEPSRNSSSSVQSRKQEIIKVTEQLIEAINNGDFEAYTKICDP 435

  Fly   420 HLTAFEPEALGNLVEGIDFHKFYFENVLGKNCKAINTTILNPHVHLLGEEAACIAYVRLTQYIDK 484
            .||:||||||||||||:|||:|||||.|.|:.|.::|.||||||||:||:||||||:|||||:|.
Frog   436 GLTSFEPEALGNLVEGMDFHRFYFENALSKSNKPVHTIILNPHVHLIGEDAACIAYIRLTQYLDS 500

  Fly   485 QGHAHTHQSEETRVWHKRDNKWQNVHFHRSASAKI 519
            .|...|.|||||||||:||.||||||||||.|..|
Frog   501 TGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTI 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	251/290 (87%)
		S_TKc	14..272	CDD:214567	223/257 (87%)
		CaMKII_AD	390..517	CDD:285524	96/126 (76%)
camk2d	XP_017952440.2	STKc_CaMKII	11..302	CDD:270988	251/290 (87%)
camk2d	XP_017952440.2	CaMKII_AD	406..533	CDD:285524	96/126 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I431
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55561
Inparanoid	1	1.050	783	1.000	Inparanoid score	I516
OMA	1	1.010	-	-		QHG52374
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	1	1.000	-	-		FOG0000706
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3212
SonicParanoid	1	1.000	-	-		X46
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.110