DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtg4

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001038759.2	Gene:	vtg4 / 678536	ZFINID:	ZDB-GENE-001201-3	Length:	1358	Species:	Danio rerio

Alignment Length:	1621	Identity:	327/1621 - (20%)
Similarity:	564/1621 - (34%)	Gaps:	471/1621 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDS-DDTSLKVSGSAKI 82
            ||:|:.|....||        :.::.....|.|.::::|..|    :|.:. ....:|||....:
Zfish     8 LTVALVASQQMNL--------VPEFAHDKTYKYKYEALLLGG----LPQEGLARAGIKVSSKVLL 60

  Fly    83 FAKGNCGYTLQLSSVKV-----TNTKES------VEKKILNSIQKPVQFTLVSGILEPQICSDSS 136
            .|.....|.::|....:     |..|:|      :...:...:|.|::|...:|:: .::.:.:.
Zfish    61 SAVTENTYLMKLMDPLLYEYAGTWPKDSFVPATKLTSALAAQLQIPIKFEYANGVV-GKVFAPAG 124

  Fly   137 DLDYSLNIKRAVVSLLQSGIEAE------HEVDVFGMCPTHTSTSKVGNAN--IITKARNLNSCS 193
            .....:|:.|.::::||..::..      .|....|:|.||...::....|  |:||:::|:.|.
Zfish   125 VSPTVMNLHRGILNILQLNLKKTQNIYELQEAGAQGVCRTHYVINEDPKTNHIIVTKSKDLSHCQ 189

  Fly   194 HREQINSGLV-SGKVNEKAGITSSLLLQA--NYIKESRIVNHLIENVQLTETYKFIGNTKRNSDI 255
            .|...:.||. :.:..|......||:..|  |||.:......||....:.|.|:|....:.:...
Zfish   190 ERIMKDVGLAYTERCAECTKRVKSLIETATYNYIMKPADNGALIAEATVEEVYQFSPFNEIHGAA 254

  Fly   256 SAKVVTILKLKNPSGT-----KANSPGTGS---TVRSLIFQRPETYTSKNINALK---------T 303
            ..:....|.......|     ||:....||   ...:.|.|.|       |..:|         .
Zfish   255 MMEAKQTLAFVEIEKTPVVPFKADYMHRGSLQYEFATEILQTP-------IQLMKISDAPAQIVE 312

  Fly   304 ILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAFPHPNKVLARKVYLDGLFRTSTAE 368
            :|..||.:..|.|..:...|||:.::|||.:..|. :|.......:|.:.|:..||.|    .|.
Zfish   313 VLKHLVANNKDMVHDDAPLKFVQLVQLLRVATLEK-IEAIWSQFKDKPVYRRWLLDAL----PAV 372

  Fly   369 SARVILKQLSKFDEKEKLLA------------ILSLNIVKSVDKETLNQAAS-------QLLPNA 414
            ...||:|.:     |||.||            :::|..| |.|.||:...||       ..:|..
Zfish   373 GTPVIIKFI-----KEKFLAGEFTTPEFIQTLVIALQRV-SADLETIQMTASLAMHEKFSTVPAL 431

  Fly   415 PKELYIAVGNLVAKYCLK-NYCQGPEIDAISKKFSDGLKHCKPNTKREEERIVYILKGLGNA--- 475
            .:...:..|:|:|::|:. ..|....:..|.:..::.:      :|.:...|...||.:|||
Zfish   432 REVAMLGYGSLIARHCIAVPTCPAELLRPIHEIATEAV------SKNDIPEITLALKVMGNAGHP 490

  Fly   476 -------KSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKCEE--TLQSKSLELLKNRNEDSE 531
                   |.|.|...||      .....|::|.|:.|...:..:|  .:|..:|:|:.:|....|
Zfish   491 SSLKPIMKLLPGLRTAA------NALPVRVQVDAILALRNIAKKEPKLVQPIALQLVLDRALHPE 549

  Fly   532 LRIEAYLSAISC-PNAEVANQISEIVNSETVNQVGGFISSNLKAIRDSTDVSRDQQKY--HLANI 593
            :|:.|.:..... |:..:.:.::..:.:|....|..|..|::|::   |.::.....|  ..||:
Zfish   550 VRMVACIVLFEAEPSVALISSLAGALRTEPNMHVASFAYSHIKSL---TRITAPDMAYVAGAANV 611

  Fly   594 RV----TKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLPRSSRINVTTEFFGTNY 654
            .:    .|...::| |||...::.|....|.:||:....:|......|||:..........|...
Zfish   612 AIKLMNCKLDRLNY-RYSRAFKMDYYYTPLMIGAAGSAYMINDAATILPRAVVAKARAYLAGAAA 675

  Fly   655 NVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGGRARRSIVDDVSKISKKY 719
            :|.|..||...:.:.|        |.:...||                     .||.::||  |.
Zfish   676 DVVEFGVRTGGIHEAL--------LKSPAADE---------------------SVDRITKI--KR 709

  Fly   720 KMYGVKNVQDLNLDVSL-----KLFGSELAFLSLGDNIPSSLDDIINYFSTSFEKA--------- 770
            .:..:.|.:.|..|..|     |:||.|:|:              :|:..|..|:|
Zfish   710 TLRALTNWKALPTDKPLASAYVKVFGQEVAY--------------VNFDKTIIEEAIPMVTGPKP 760

  Fly   771 ----KQELSSFEK----QFSSHHLFLDTDLAYPTSIGVPLELVAQGFAATKVDLAVSLDINAILE 827
                |:.|.:.::    |::...|..:.....||::|||:|......|.....:.|...:...|.
Zfish   761 RALLKEALKALQEGIAFQYAKPLLAAEVRRILPTAVGVPMEFSWYTAAVAAASVNVQATVTPALP 825

  Fly   828 QNWQKAKY-RLKFV---------PSVDINANVQIGFN-----AQVLSTG-LRVVSSAHSATGSDI 876
            :..:...| :||..         |||.:.....:|.|     |.|::.| :|.::....|..:||
Zfish   826 EKLESMTYEQLKKTDVQFQAEARPSVALQTFAVMGVNTAFIQAAVMARGKIRTIAPGKVAARADI 890

  Fly   877 TVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNKNSQPSEICFNQL 941
                                                         ||||.| ..:.|.::
Zfish   891 ---------------------------------------------LKGNYK-VEALPVDL----- 904

  Fly   942 ELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSRPFNFAVYLTTERKFTFKGIHTQEAF 1006
               ..:|...|..:|:.|:....:.|||          |.||                  ..|..
Zfish   905 ---PEHIASASFETLAVVRNIEDHSAER----------SVPF------------------VPELS 938

  Fly  1007 SQKWKLDYSTP-GSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHFAVEGGINNDKNELVVYGQYE 1070
            .|..:..|:.. .|:||.|.:|     ..|     ..||.:.|:             .|.|
Zfish   939 LQNSQASYAGDLSSEVSPDASV-----RAP-----APFDRTLCY-------------AVPY---- 976

  Fly  1071 QDKEIKKSKIGFSKNGNEYKPLIEIQDNNG--ISNS----INGYHADGKIVVKKNSNNIERYNFE 1129
                            .|.|..:|:..:|.  |.||    |.|:|.....|.:.....:||..||
Zfish   977 ----------------IEIKGCVEVHSHNAAFIRNSTLFYIIGHHTARAAVSRAEGPAVERLEFE 1025

  Fly  1130 NFQVSNSNNAHVAVNGWSDVGTNS---LTSELRISLDH----QTFLIKENLKLENGLYEAGFFIN 1187
                             ..||..:   |..::.|..|.    |.||:|....|:.....|.  ::
Zfish  1026 -----------------VQVGPRAAERLLKQINIIDDDTPEGQAFLLKLREILDTEAKNAP--VS 1071

  Fly  1188 DEHSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSD--GSFNFQKLA---------------- 1234
            .|.|..:...|.   :.:..|.:..::|.:::.|..|.  .|....|.|
Zfish  1072 SESSSSSSRNSR---STSSSSTSTSSSGSSSSSSSSSSSMSSSRMSKTATIMEPFRKFHKDRYLA 1133

  Fly  1235 ------DSNSARAGSLVENVEIQYKNKQVG---------------------GIKIMSNFDVNKMD 1272
                  |::|..|.:..|  ::|.||:.:|                     |.::.:.|
Zfish  1134 PHSATKDTSSGSAAASFE--QMQKKNRFLGNDIPPVFAIIARAVRADQKLLGYQLAAYF------ 1190

  Fly  1273 VDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVYVVDNSLVTSWG 1337
             |...:|.|.|.|.|.: ..|.:...|     .|.::||.:                 :...|||
Zfish  1191 -DKPTARVQLIASSIAE-NDNMKICAD-----GALLSKHKV-----------------TAKFSWG 1231

  Fly  1338 T-----LLSAKGEIG--QRYSAQDININIQGNVQISG--KDKVTQWILKVIGTPDKTNSDFRISR 1393
            .     .:.||.|.|  ..|.|..:.:..:...:|:.  ..||:::||..     ..::.||..|
Zfish  1232 AECKQYAVFAKAEAGVLGEYPAARLEVEWERLPKIASTYAKKVSKYILNA-----AYDTGFRFER 1291

  Fly  1394 DTSELIKLTSESQHPQDKISFAKLNLIVK-NQLTAKGE-----FRVAKNGKGDFTASIDTL 1448
            .|:...::...:..|..|    .||:|.: .::|....     ..|..|..|.||...|.|
Zfish  1292 ATNSEKEIELTAALPSQK----SLNVIARIPEITMSRRDIYLPVTVPINPDGTFTIDKDFL 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	130/602 (22%)
		DUF1943	605..911	CDD:286281	66/343 (19%)
		DUF1081	932..1031	CDD:283982	19/99 (19%)
		VWD	2789..2931	CDD:214566
vtg4	NP_001038759.2	Vitellogenin_N	24..592	CDD:279663	130/602 (22%)
		DUF1943	626..917	CDD:286281	74/389 (19%)
		DUF1944	1166..1330	CDD:286284	37/202 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910