DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtg8

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	XP_021325376.1	Gene:	vtg8 / 560066	ZFINID:	ZDB-GENE-091106-1	Length:	1553	Species:	Danio rerio

Alignment Length:	1719	Identity:	327/1719 - (19%)
Similarity:	587/1719 - (34%)	Gaps:	518/1719 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 LLKYIPG-NYYDYSFDSILTIGASSDVPNDSDDTSLKVSGSAKIFAKGNCGYTLQLSSVKV---- 99
            |:.::.| ..|.|.::::|..|...   .|.....:|::....|.|..:..:.|:||:.::
Zfish    26 LVPHLAGPQTYVYRYEALLFSGLHQ---KDLARAGIKINSKVLIIAADDNIFLLKLSNPQLFEYS 87

  Fly   100 --------TNTKESVEKKILNSIQKPVQFTLVSGI--------LEPQICSDSSDLDYSLNIKRAV 148
                    ..:|.::|  :...:|.|::|...:|:        |.|.|.         :|:.|.:
Zfish    88 GIWPEDTFVTSKFTLE--LAAQLQIPIKFEYTNGMVGKLFIPSLVPTIV---------INLYRGI 141

  Fly   149 VSLLQSGIEAEHEV------DVFGMCPTH--TSTSKVGNANIITKARNLNSCSHREQINSGLVSG 205
            :::.|..::....|      .:.|:|.|.  .|..:..|...|.|:::|.||..|...:.||
Zfish   142 LNIFQLNLKKTQNVYEIQEDGIQGICKTQYVISEDEENNHTTIIKSKDLTSCHKRIMKDVGL--- 203

  Fly   206 KVNEKAGITSSLLLQANYIKESRIVNHLIENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSG 270
                            :|:::.......|::.....||.:                ||| ..|:|
Zfish   204 ----------------SYLEKCIECQQKIKSYSGAVTYSY----------------ILK-PAPNG 235

  Fly   271 TKANSPGTGSTVRSL--------IFQRPETYTSKNINALKTILSDLVDSTGDYVKKETAKKFVEF 327
            ...    |.:|||.:        |....:..|.:.:..|:.:.:|::..:.||:.:.|.:  .||
Zfish   236 VMI----TEATVREIHQFTPQYEIGDATQMETRQTLTFLEIMTTDIIPISADYLARGTLQ--YEF 294

  Fly   328 --------IRLLRQSDSET--------------------------LLELAAF------------- 345
                    |:|::.||::.                          |::|..|
Zfish   295 STETLWSPIQLMKISDAQAQIVDALNNLATKKKEVHEDVPLKYIHLIQLMRFASVDAVEGIWSQF 359

  Fly   346 -PHPNKVLARKVYLDGLFRTSTAESARVILK-----QLSKFDEKEKLLAILSLNIVKSVDKETLN 404
             ..||   .||..||.:....|..:.:.|.|     :|| |.|..::|.:....:..::|  |:.
Zfish   360 KTRPN---FRKWILDAIPAVGTLAALKFIKKTFLAGELS-FSEFTQVLLVAVHMVTANLD--TIK 418

  Fly   405 QAASQLLPNAPKE-------LYIAVGNLVAKYCLKNYCQGP-EIDAISKKFSDGLKH-----CKP 456
            ..:|..|.:..:|       ..:..|.::|:|| ....:.| |:          |||     .|.
Zfish   419 MYSSLALHHKVQETPVLREIAMLGYGTMIARYC-SGALECPVEL----------LKHIHEIATKV 472

  Fly   457 NTKREEERIVYILKGLGNAK------------SLSGNTVAALSECASTGRSNRIRVAA---LHAF 506
            :.|.:...|..|||.||||.            .:.|..:...        ..|::|.|   |.|.
Zfish   473 SAKADIAEITLILKVLGNAAHPASIKYITKFLPIFGTHIHQF--------PMRVQVDAILTLKAL 529

  Fly   507 SKVKCEETLQSKSLELLKNRNEDSELRIEAYLSAISC-PNAEVANQISEIVNSETVNQVGGFISS 570
            :|.:.::.| :..|:|..|::...|||:.:::..... |:..:...::..:.||...||..|..|
Zfish   530 AKKESKQVL-NVVLQLFLNKDLHPELRMLSWIVIFETKPSMGLVITLARGLRSEKNLQVSSFAYS 593

  Fly   571 NLKAIRDSTDVSRDQQKYHLA-NIRVTKTFPVDYRRYSFNNEVSYKLES----LGVGASTDYQII 630
            ::||:..||  :.|.....:| |:.: |.......:.||....::.|:.    |..||:.....|
Zfish   594 HMKALARST--APDFALIAIACNVAI-KILSPKLDKLSFLYSKAFLLDGYTYPLMDGAAASAFFI 655

  Fly   631 YSQHGFLPRSSRINVTTEFFGTNYNVFEAS-----------VRQENVEDVLEYYLGPKGLVNKDF 684
            ......|||.....|.....|...:|||.|           :|.:.:::||  ...|  .:|:|.
Zfish   656 NDATTILPRVVVAKVHAYLAGAAADVFEVSSSGDTILLYVGIRTDGIQEVL--LKSP--FLNEDG 716

  Fly   685 DEIVKLIEVGNNGVAAGGRARRSIVDDVSKISKKYKMYGVKNVQDLNLDVSLKLFGSELAFLSLG 749
            ...::.:          .:|.:|.    ..:|||         |.:. .:.:||||.|:||.::.
Zfish   717 QPTIRQL----------FQALKSF----KTLSKK---------QHIG-SIYIKLFGQEIAFANVD 757

  Fly   750 DNIPSSLDDIINYFSTSF------EKAKQELSSFEKQFSSHHLFLDTDLAYPTSIGVPLELVAQG 808
            ..:   |:..|.:.:...      |..|:..:....|::...|..:....:|::.|||:||..
Zfish   758 KAV---LEQAIQFTTEGHMVELIEEALKKMQNGIVFQYAKPLLMGEVRHIFPSAAGVPMELSL-- 817

  Fly   809 FAATKVDLAVSLDINAILEQNWQK-----------AKYRLKFVPSVDINANVQIGFNAQVLSTGL 862
            :||..|  |.:|::.||:.....:           .|...:..||:.:.|....|.|     ||.
Zfish   818 YAAAVV--AGNLNVQAIITPPLTELTSVAHLMKTDVKVTAEISPSIALQAFAVAGIN-----TGF 875

  Fly   863 RVVSSAHSATGSDITVAVISDGEGFNVDLELPREKLEL--INFNVD--TELYVAEQDKQKAIALK 923
              :.:|..|.|...|:..:.....|  |:.....||:.  |.|.|.  |..||....
Zfish   876 --IQAASIARGKIHTLMPLKVVGKF--DITHANFKLQTFPIAFPVHAVTAQYVTVHS-------- 928

  Fly   924 GNKKNKNSQPSEIC---FNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSRPFNF 985
                         |   |..:.|:...:|...::|...:.|. ||:.:              .|.
Zfish   929 -------------CLHHFTTVYLINNILCFLFNSSFETLSAA-GNIED--------------VNA 965

  Fly   986 AVYLTTERKFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHF 1050
            .:...|..|.    :..|.  ||.......:||:..|..   |......|:..|.:....:.|..
Zfish   966 QIIKPTLPKM----VVVQS--SQNTLTSIISPGALSSEP---VMPPVKDPELRSIVPVHKTLCSV 1021

  Fly  1051 AVEGGINNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEYKPL-------IEIQDNNGISNSI--- 1105
            ....||             :...|:......|.||...|..:       :|:|.....:..:
Zfish  1022 IPHIGI-------------KTCMEVLSCNAAFIKNTTLYNMIGQHGGLELEVQLGARAAKKLLKE 1073

  Fly  1106 --NGYHADGKIVV-----------KKNSNNIERYNFENFQV---------SNSNNAHVAVNGWSD 1148
              |.|....||..           :|...:...:|.:..|:         |:|::.|.:::..|:
Zfish  1074 INNVYLKTPKIKTILQKLREILEGRKRDKSSRFFNHKKIQIAPSSSRRSFSSSSSVHDSISHLSE 1138

  Fly  1149 VGTNSLTSELRISLDHQTFLIKENLKLENGL--YEAGFFINDEHSPENIYGSSIHLTIADQSYAL 1211
              |.||..    |:.....:|...:::::.|  |:...:::..:       |.:.:.:.  |.|.
Zfish  1139 --TRSLVD----SVPPVVAIIGRVVRVDHKLLGYQLTAYVDRPN-------SRVQMIVV--SIAA 1188

  Fly  1212 KTNGKAAAWSIGSDGSFNFQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFDVNKMDVDVE 1276
            |.|     |                                                 ||..|..
Zfish  1189 KDN-----W-------------------------------------------------KMCADAV 1199

  Fly  1277 ISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNG---NVYV-VDNSLVTSWG 1337
            :..:|   :|:.|            :...|:..|::|.:......:|   .||: |....|..:.
Zfish  1200 LMSKQ---TIVAK------------MAWGAESPKYAITIKGGTGHHGPSPMVYLKVKCEKVPRFI 1249

  Fly  1338 TLLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTNSDFRISRDTSEL---- 1398
            |..| |...|....|.::.     .:.||.:..:.:.|..:|...|....|..|......|
Zfish  1250 TAYS-KSVAGYIPGAAEMT-----GLTISNEKNIERQIELIILVQDLRTLDIIIKTPLMTLSKTN 1308

  Fly  1399 ----IKLTSESQHPQDKISFAKLNLIVKNQLTAKGEFRVAKNGKGDFTASIDTLKTEPKHKLEI- 1458
                |.|..|: :|:|.:.....||           ::.|.:.|.....||.|......:..||
Zfish  1309 LVLPIALPFEA-YPEDNVIKMIQNL-----------YKEASSAKCSKVRSILTTFNHRTYNCEIP 1361

  Fly  1459 -------------ESKFHIQSPKYDIDASLTLDGK---RKVHLKSENTIEKLKFSTKNIGEANDK 1507
                         |.||.|...|.|:.....|..|   ..|.|..::::.|::.:...:  ..||
Zfish  1362 LSFYQVLVQDCTSEHKFLILMKKDDVYKHEVLSIKVADIAVQLYQQDSVIKVRINGTEV--TTDK 1424

  Fly  1508 IIAFEANGSLKGELRGNGEIQGTFIFNAP 1536
            |......|::..|.:|.|     ..|.||
Zfish  1425 IPYHHPTGTIHIEKKGAG-----IAFYAP 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	126/648 (19%)
		DUF1943	605..911	CDD:286281	74/341 (22%)
		DUF1081	932..1031	CDD:283982	18/101 (18%)
		VWD	2789..2931	CDD:214566
vtg8	XP_021325376.1	Vitellogenin_N	34..596	CDD:279663	125/643 (19%)
		DUF1943	631..911	CDD:312626	68/323 (21%)
		DUF1944	1148..1312	CDD:312629	36/247 (15%)
		VWD	1349..1492	CDD:214566	24/107 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910