DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtg2

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001038378.1	Gene:	vtg2 / 559931	ZFINID:	ZDB-GENE-001201-2	Length:	1631	Species:	Danio rerio

Alignment Length:	1857	Identity:	366/1857 - (19%)
Similarity:	619/1857 - (33%)	Gaps:	601/1857 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KYNIALI-GILASVLLTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPND 68
            ||...|: ||:...|....:..::...|.....:..|||::...:|:|          :...|.|
Zfish    33 KYEALLLSGIVQEGLAKAGIQIKSKVLLSAATENTFLLKFVDPLFYEY----------AGTWPKD 87

  Fly    69 SDDTSLKVSGSAKIFAKGNCGYTLQLSSVKVTNTKESVEKKILNSIQKPVQFTLVSGIL----EP 129
            ....:.|::.:                              :...:|.|::|...:|::    .|
Zfish    88 QVFPATKLNSA------------------------------LAAQLQTPIKFEYANGVVGKVFAP 122

  Fly   130 QICSDSSDLDYSLNIKRAVVSLLQ------SGIEAEHEVDVFGMCPTHTSTSKVGNAN--IITKA 186
            ...|.|     .||:.|.::::||      ..|....|....|:|.|....|:...|:  .:||:
Zfish   123 AGVSPS-----VLNLYRGILNILQLNFKKTQNIYELQEAGAQGVCKTQYVISEDPKADRITVTKS 182

  Fly   187 RNLNSCSHREQINSGLV-SGKVNEKAGITSSLLLQANY------------IKESRIVN------- 231
            |:|:.|..|...:.||. :....|......||:..|||            |.|:.:..
Zfish   183 RDLSHCQERIVKDIGLAYTETCVECTKRIKSLIETANYNYIIKPSDSGALIAEATVKEVHQFSPF 247

  Fly   232 ---HLIENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVRSLIFQRPETY 293
               |....::.|::..|:...|      |.||.:.....|.|:......|.      |.|.|...
Zfish   248 NEIHGAAMMEATQSLVFVEFEK------APVVPVKADYMPRGSLQYEFATE------ILQTPIQL 300

  Fly   294 TSKNINA---LKTILSDLVDSTGDYVKKETAKKFVEFIRLLRQS---DSETLLELAAFPHPNKVL 352
            | |..||   :|.:|..||::....|..:...|||:.::.||.:   |:|.:  .|.|..
Zfish   301 T-KISNAPAQIKEVLKHLVENNVAMVHDDAPLKFVQLVQFLRAATLKDTEAI--WAQFKD----- 357

  Fly   353 ARKVYLDGLFRTSTAESARVILKQLSKFDEKEKLLA------------ILSLNIVKSVDKETLNQ 405
             :.||...|..|..|.:..|:||.:     |||.||            :::|.:|.: |.||:..
Zfish   358 -KPVYRRWLLDTLPAVATPVVLKFI-----KEKFLAGEFTLTEFIPTLVVALQMVPA-DLETIQW 415

  Fly   406 AASQLL-------PNAPKELYIAVGNLVAKYCLK-NYCQGPEIDAISKKFSDGLKHCKPNTKREE 462
            .||..|       |...:.:.:..|:::||||:. ..|....:..|.:..::.:      :|.:.
Zfish   416 TASLALHEKIATIPALREVVMLGYGSMIAKYCVAVPTCPAELLRPIHEIATEAI------SKNDI 474

  Fly   463 ERIVYILKGLGNAKSLSG-NTVAALSECASTGRSN---RIRVAALHAFSKVKCEE--TLQSKSLE 521
            ..|...||.||||...|. ..:..|.....|..|.   |::|.|:.|...:..:|  .:|..:|:
Zfish   475 PEITLALKVLGNAGHPSSLKPIMKLLPVLKTTASALPIRVQVDAILALRSIAKKEPKLVQPVALQ 539

  Fly   522 LLKNRNEDSELRIEAYLSAISC-PNAEVANQISEIVNSETVNQVGGFISSNLKAIRDST--DVSR 583
            |:..|....|||:.|.:..... |:..|.:.::..:..||..||..|..|::|::...|  |:|.
Zfish   540 LVLERALHPELRMVACILLFETKPSVAVMSSLAGALRMETNMQVASFAYSHIKSLTRITAPDMSS 604

  Fly   584 -----------DQQKYHLANIRVTKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFL 637
                       ..:|....|.|.::.|.:|:..           ..|.:||:....:|......|
Zfish   605 VAGAANVAIKLMNRKLDRLNFRYSRAFQLDFYH-----------TPLMIGAAGSAYMINDAATIL 658

  Fly   638 PRSSRINVTTEFFGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGG 702
            ||:..........|...:|.|..:|.|.:::.|        |.:...||
Zfish   659 PRAVIAKARAYLAGAATDVIEFGLRTEGIQEAL--------LKSPAADE---------------- 699

  Fly   703 RARRSIVDDVSKISKKYKMYGVKNVQDLNLDVS---LKLFGSELAFLSLGDNIPSSLDDIIN--- 761
                 .||.::||.:..:..........|..::   :|:||.|:||..:...|......::|
Zfish   700 -----SVDRITKIKRTLRALTNWKAMPSNKPLASAYVKVFGQEMAFGRIDKTIIEQALPMVNGPK 759

  Fly   762 --YFSTSFEKAKQELSSFEKQFSSHHLFLDTDLAYPTSIGVPLEL----VAQGFAATKVDLAVSL 820
              .......||.||..|:::  :...|..:.....|||:|:|:||    ...|.|...|...::.
Zfish   760 PRALLKEALKALQEGISWQR--AKPLLVAEVRRILPTSVGLPMELSMYSSVVGAATVNVQATITP 822

  Fly   821 DI-----NAILEQ-NWQKAKYRLKFVPSVDINANVQIGFN-----AQVLSTG-LRVVSSAHSATG 873
            .:     ...||| .....:::.:..||:.|:....:|.|     |.|::.| :|.::....|..
Zfish   823 PLPEQIETMTLEQLKKTDVQFKAEARPSIAIHKFAVMGVNTAFIQAAVMARGKIRTIAPGKVAAR 887

  Fly   874 SDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNKNSQPSEICF 938
            :||                                             ||||.|
Zfish   888 ADI---------------------------------------------LKGNYK----------- 896

  Fly   939 NQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVS-EKFHLSRPFNFAVYLTTERKFTFKGIHT 1002
                                ::|....:.|...|.| |.|..:|
Zfish   897 --------------------IEALPVELPEHIASASFETFAFAR--------------------- 920

  Fly  1003 QEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHFAVEGGINNDKNELVVYG 1067
                      |...|.::.:.....|..|.|:..  .|||.:|:......|..:
Zfish   921 ----------DVEDPSAERTVPLVSVLSLQNRQS--QRLSSENADSEIETETPV----------- 962

  Fly  1068 QYEQDKEIKKSKIGFSKN------GNEYKPLIEIQDNNG--ISNS----INGYHADGKIVVKKNS 1120
                     |:...|.:.      ..|.|..:|:..:|.  |.||    |.|.|:....|.:...
Zfish   963 ---------KAPAPFDRTLCYAVPYIEIKGCVEVHSHNAAFIRNSTLFYIIGQHSARAAVARAEG 1018

  Fly  1121 NNIERYNFENFQVSNSNNAHVAVNGWSDVGTNS---LTSELRISLDHQT-----FLIK--ENLKL 1175
            ..:|:..||                 ..||..:   |..::.| :|.:|     ||:|  |.|:.
Zfish  1019 PAVEKLEFE-----------------VQVGPRAAERLAKQINI-IDDETPEGKDFLLKLREILET 1065

  Fly  1176 E--NGLYEAGFFINDEHSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSDGSFN--------- 1229
            |  |....:|       |..:...||...:.:..|.:..|:..:::.|..|..|.:
Zfish  1066 ESKNATVSSG-------SSSSRSSSSSRSSSSSSSTSNSTSSSSSSSSSSSSMSSSRWSKTLTKM 1123

  Fly  1230 --FQKL---------ADSNSARA-GSLVENVEIQYK-------------------NKQVGGIKIM 1263
              |:|.         .||.|:|: ||.:|.::.|.:                   ::::.|.:.:
Zfish  1124 EAFRKFHKDQYKTHHGDSKSSRSTGSSLEQIQKQSRYLGNTVPPVFAIIARAVRVDRKLLGYQFV 1188

  Fly  1264 SNFDVNKMDVDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVYVV 1328
            :.||...       ||.|.|.|.|.: ..|.:...|..|     ::||.:
Zfish  1189 AFFDKPS-------SRVQFIASSIAE-NDNFKFCADGVL-----LSKHKV--------------- 1225

  Fly  1329 DNSLVTSWGT-----LLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTNSD 1388
             .|.|| ||.     .::.|.|.|                 :.|:...
Zfish  1226 -TSKVT-WGAECKEYAVTTKAEAG-----------------LLGEFPA----------------- 1254

  Fly  1389 FRISRDTSEL-IKLTSESQHPQDKISFAKLNLIVKNQLTAKGEFRV--AKNGKGDFTASIDTLKT 1450
            ||:..:...| |..|:.::.....|..|.|          :..|.|  |||.:.:...   |:..
Zfish  1255 FRLEWEWERLPIIFTTYAKKLSKHIPMAAL----------QAGFNVERAKNSEKELEL---TVAL 1306

  Fly  1451 EPKHKLEIESKF-HIQSPKYDIDASLTL----DGKRKVH------LKSENTIEKLKFSTKNIGEA 1504
            ..|..|.:..:. .:...:.||...:|.    ||...||      .:::|.|  ..::|......
Zfish  1307 PSKRTLNVIVRVPEMTMSRMDIPLPVTFPINPDGTFDVHFYEDIYFRAQNYI--YDYTTAQCSMM 1369

  Fly  1505 NDKIIAFEANGSLKGEL----------RGNGEIQGTFIFNAPDGRVIDGSINRKISTNAKSGLSQ 1559
            .|.|..|. |.:.|.|:          ....|::  |:           ::.:|...:.|:.|:.
Zfish  1370 QDTISTFN-NKTYKNEMPISCYQVLAQDCTSELK--FV-----------ALLKKDEESEKTHLNV 1420

  Fly  1560 GNIDAQLSDTPFGSNKKRSISLIGKLDRLNTKTKEFSANSNLVYTAFNGEKSEISYQIKQQPNGD 1624
            ..:|..:.....|::.|..|                           ||.:..||....|.|:|
Zfish  1421 KLVDIDIDLYTLGTDAKVKI---------------------------NGLEVPISSLPYQHPSG- 1457

  Fly  1625 AKNIDFSLKAYGNPLPQP----FEIAFALGDYSAQHA 1657
              :|....||.|..|..|    .|:.||.||:..|.|
Zfish  1458 --SIQIREKADGLSLYAPSLGLHEVYFANGDWKIQVA 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	133/597 (22%)
		DUF1943	605..911	CDD:286281	60/329 (18%)
		DUF1081	932..1031	CDD:283982	10/99 (10%)
		VWD	2789..2931	CDD:214566
vtg2	NP_001038378.1	Vitellogenin_N	24..592	CDD:279663	143/636 (22%)
		DUF1943	626..917	CDD:286281	73/408 (18%)
		DUF1944	1167..1331	CDD:286284	41/240 (17%)
		VWD	1362..1519	CDD:214566	36/175 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910