DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtg7

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001096141.1	Gene:	vtg7 / 559856	ZFINID:	ZDB-GENE-001201-6	Length:	1358	Species:	Danio rerio

Alignment Length:	1588	Identity:	303/1588 - (19%)
Similarity:	564/1588 - (35%)	Gaps:	427/1588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDS-DDTSLKVSGSAKI 82
            ||:|:.|....||        :.::.....|.|.::::|..|    :|.:. ....:|||....:
Zfish     8 LTVALVASQQMNL--------VPEFAHDKTYVYKYEALLLGG----LPQEGLARAGIKVSSKVLL 60

  Fly    83 FAKGNCGYTLQL------------------SSVKVTNTKESVEKKILNSIQKPVQFTLVSGILEP 129
            .|.....|.::|                  .:.|:|:.       :...:|.|::|...:|:: .
Zfish    61 SAMTENTYLMKLMDPLLYEYAGTWPKDPFVPATKLTSA-------LAAQLQIPIKFEYANGVV-G 117

  Fly   130 QICSDSSDLDYSLNIKRAVVSLLQSGIEAE------HEVDVFGMCPTHTSTSKVGNAN--IITKA 186
            ::.:.:......:|:.|.::::||..::..      .|....|:|.||...::....|  |:||:
Zfish   118 KVFAPAGVSPTVMNLYRGILNILQLNLKTTQNIYELQEAGAQGVCRTHYVINEDPKTNHIIVTKS 182

  Fly   187 RNLNSCSHREQINSGLV-SGKVNEKAGITSSLLLQA--NYIKESRIVNHLIENVQLTETYKF--I 246
            ::|:.|..|...:.||. :....|......||:..|  |||.:......||....:.|.|:|  .
Zfish   183 KDLSHCQERIMKDVGLAYTESCPECTERVKSLIETATYNYIMKPADNGALIAEATVEEVYQFSPF 247

  Fly   247 GNTKRNSDISAK-VVTILKL-KNP-SGTKANSPGTGS---TVRSLIFQRPETYTSKNINALK--- 302
            ......:.:.|| .:..::: |.| ...||:....||   ...:.|.|.|       |..:|
Zfish   248 NEIHGAAMMEAKQTLAFVEIEKTPVVPIKADYMPRGSLQYEFATEILQTP-------IQLMKISD 305

  Fly   303 ------TILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAF--PHPNKVLARKVYLD 359
                  .:|:.||.:..|.|..:...|||:.::|||.|   ||.:..|.  ...||.:.|:..||
Zfish   306 ATAQIVEVLTHLVANNKDMVHDDAPLKFVQLVQLLRLS---TLDKFEAIWAQFKNKPVYRRWLLD 367

  Fly   360 GLFRTSTAESARVILKQLSKFDEKEKLLA------------ILSLNIVKSVDKETLNQAAS---- 408
            .|    .|....||:|.:     |||.||            :::|.:| :.|.||:....|
Zfish   368 AL----PAVGTPVIIKFI-----KEKFLAGEFTTPEFIQTLVVALQMV-TADLETIQMTYSLATH 422

  Fly   409 ---QLLPNAPKELYIAVGNLVAKYCLK-NYCQGPEIDAISKKFSDGLKHCKPNTKREEERIVYIL 469
               ..:|...:.:.:..|:|:||:|:. ..|....:..|.:..::.:      :|.:...|...|
Zfish   423 EKFTTIPALREVVMLGYGSLIAKHCVAVPSCPAELLKPIHEITAEAI------SKNDIPEITLAL 481

  Fly   470 KGLGNA----------KSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKCEE--TLQSKSLEL 522
            |.:|||          |.|.|...||      .....:::|.|:.|...:..:|  .:|..:|:|
Zfish   482 KVMGNAGHPSSLKPIMKLLPGLRTAA------NALPIKVQVDAILALRNIAKKEPKLVQPIALQL 540

  Fly   523 LKNRNEDSELRIEAYLSAISC-PNAEVANQISEIVNSETVNQVGGFISSNLKAIRDST------- 579
            :.:|....|:|:.|.:..... |:|.:.:.::..:..|....|..|..|::|::...|
Zfish   541 VLDRALHPEVRMVACIVLFEAKPSAALVSSLAGALRIEPNMHVASFAYSHIKSLTRITAPDMASV 605

  Fly   580 ------DVSRDQQKYHLANIRVTKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLP 638
                  .:....:|....|.|.::.|.:||..           ..|.:||:....:|......||
Zfish   606 AGAANVAIKLMNRKLDRLNYRYSRAFHMDYYH-----------TPLMIGAAGSAYMINDAATILP 659

  Fly   639 RSSRINVTTEFFGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGGR 703
            |:......|...|...:|.|..||...:.:.|        |.:...||
Zfish   660 RAIVAKARTYLAGAAADVIEFGVRTGGIHEAL--------LKSSAADE----------------- 699

  Fly   704 ARRSIVDDVSKISKKYKMYGVKNVQDLNLDVSL-----KLFGSELAFLSLGDNIPSSLDDIINYF 763
                .||.::||.:..|  .:.|.:.|..|..|     |:||.|:|:::....|   :::.|...
Zfish   700 ----SVDRITKIKRTLK--ALANWKALPTDRPLASAYVKVFGQEVAYVNFDKTI---IEEAIPMV 755

  Fly   764 STSFEKA--KQELSSFEK----QFSSHHLFLDTDLAYPTSIGVPLELVAQGFAATKVDLAVSLDI 822
            |....:|  |:.|.:.::    |::...|..:.....||::|||:|......|.....:.|...|
Zfish   756 SGPKPRALLKEALKALQEGVAFQYAKPLLAAEVRRILPTAVGVPMEFSLYTAAVAAASVNVQATI 820

  Fly   823 NAILEQNWQK----------AKYRLKFVPSVDINANVQIGFN-----AQVLSTG-LRVVSSAHSA 871
            ...|.:..:.          .:::.:..|||.:.....:|.|     |.|::.| :|.::....|
Zfish   821 TPALPEKLESMTLDQLKRTDVQFQAEARPSVALQTFAVMGVNTAFIQAAVMARGKIRTIAPGKVA 885

  Fly   872 TGSDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNKNSQPSEI 936
            ..:||                                             ||||.| ..:.|.|:
Zfish   886 ARADI---------------------------------------------LKGNYK-VETLPVEL 904

  Fly   937 CFNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSRPFNFAVYLTTERKFTFKGIH 1001
                    ..:|...|..:|:.|:....:.|||.:.:..:..|.
Zfish   905 --------PEHIASASFETLAVVRNIEDHSAERSIPLVPELSLQ--------------------- 940

  Fly  1002 TQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHFAVEGGINNDKNELVVY 1066
                            .|:.|....:..|:.:.....:...||.:.|:..             .|
Zfish   941 ----------------NSQTSSAGDLSTEMSSAASVRASAPFDRTLCYSC-------------PY 976

  Fly  1067 GQYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNNGISNSINGYHADGKIVVKKNSNNIERYNFENF 1131
            .|.:...|:......|.||...:              .|.|.|:....|.:....::||..||
Zfish   977 IQVKGCVEVHSYNAAFIKNSTLF--------------YIIGQHSAHVAVARAEGPSVERLEFE-- 1025

  Fly  1132 QVSNSNNAHVAVNGWSDVGTNS---LTSELRISLDH----QTFLIKENLKLENGLYEAGFFINDE 1189
                           ..||..:   |..::.|..|.    |.||:|....|:.   ||      :
Zfish  1026 ---------------VQVGPRAAERLVKQMNIIDDDTPEGQAFLLKLREILDT---EA------K 1066

  Fly  1190 HSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSDGSFNFQKLADSNSARAGSLVENVEIQYKN 1254
            ::|.:...||...:.:..|.:..|:..:::.|..|..|    .::.|..::..:::|..:..:|:
Zfish  1067 NAPVSSESSSSRNSRSSSSRSHSTSSSSSSRSSSSSSS----SMSSSRLSKTATIIEPFKKFHKD 1127

  Fly  1255 KQVGGIKIMSNFDVNKMDVDVEISREQK---------IGSIIVKYESNQRHAQDYSLEA-----S 1305
            :.:.......:..........|.:::|.         :.:||.:...:.:....|.|.|     :
Zfish  1128 RYLAHHSATKDTSSGSAAASFEQTQKQNRFLGNDLPPVFAIIARAVRDDQKLLGYQLAAYFDKPT 1192

  Fly  1306 AKINKHSIDVISKCDFNGNVYV-VDNSLVT--------SWGT-----LLSAKGEIGQRYSAQDIN 1356
            |::..    :.|....|.|..: .|.:|::        |||.     .:.||.|.|.........
Zfish  1193 ARVQL----IASSIAENDNRKICADGALLSKHKVTGKFSWGAECKQYAVFAKAEAGVLGEFPAAR 1253

  Fly  1357 INIQGN----VQISGKDKVTQWILKVIGTPDKTNSDFRISRDTS--ELIKLTSE----------S 1405
            :.::..    :..:...|:.:.|||.     ..::.||..|.|:  :.|:||:.          :
Zfish  1254 LEVEWERLPIIVTTYAKKLCKHILKA-----AYDTGFRFERATNSEKEIELTAALPSQKSFDFIA 1313

  Fly  1406 QHPQDKISFAKLNLIVKNQLTAKGEFRV 1433
            :.|:..:|..::.|.|...:...|.|.:
Zfish  1314 RIPEITMSKREIPLPVAVPINPDGTFSI 1341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	133/611 (22%)
		DUF1943	605..911	CDD:286281	61/332 (18%)
		DUF1081	932..1031	CDD:283982	12/98 (12%)
		VWD	2789..2931	CDD:214566
vtg7	NP_001096141.1	Vitellogenin_N	24..592	CDD:279663	133/611 (22%)
		DUF1943	626..917	CDD:286281	74/389 (19%)
		DUF1944	1164..1328	CDD:286284	31/172 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910