DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtg1

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001038362.3	Gene:	vtg1 / 559475	ZFINID:	ZDB-GENE-001201-1	Length:	1362	Species:	Danio rerio

Alignment Length:	1497	Identity:	294/1497 - (19%)
Similarity:	528/1497 - (35%)	Gaps:	424/1497 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDS-DDTSLKVSGSAKI 82
            ||:|:.|....||        :.::.....|.|.::::|..|    :|.:. ....:|||....|
Zfish     8 LTVALVACQQFNL--------VPEFAHDKTYVYKYEALLLGG----LPQEGLARAGIKVSSKVLI 60

  Fly    83 FAKGNCGYTLQL------------------SSVKVTNTKESVEKKILNSIQKPVQFTLVSGILEP 129
            .|.....|.::|                  .:.|:|:.       :...:|.|::|...:|:: .
Zfish    61 SATTENTYLMKLMDPLLYEYAGTWPKDPFVPATKLTSA-------LAAQLQIPIKFEYANGVV-G 117

  Fly   130 QICSDSSDLDYSLNIKRAVVSLLQ------SGIEAEHEVDVFGMCPTHTSTSKVGNAN--IITKA 186
            ::.:.:......:|:.|.::::||      ..|....|....|:|.||...::...||  |:||:
Zfish   118 KVFAPAGVSPTVMNLHRGILNILQLNLKKTQNIYEMQEAGAQGVCRTHYVINEDPKANHIIVTKS 182

  Fly   187 RNLNSCSHREQINSGLV-SGKVNEKAGITSSLLLQA--NYIKESRIVNHLIENVQLTETYKF--I 246
            ::|:.|..|...:.||. :.:..|......||:..|  |||.:......||....:.|.|:|  .
Zfish   183 KDLSHCQERIMKDVGLAYTERCAECTERVKSLIETATYNYIMKPADNGALIAEATVEEVYQFSPF 247

  Fly   247 GNTKRNSDISAK-VVTILKL-KNP-SGTKANSPGTGS---TVRSLIFQRPETYTSKNINALK--- 302
            ......:.:.|| .:..::: |.| ...||:....||   ...:.|.|.|       |..:|
Zfish   248 NEIHGAAMMEAKQTLAFVEIEKTPVVPIKADYMPRGSLQYEFATEILQTP-------IQLMKISD 305

  Fly   303 ------TILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAFPHPNKVLARKVYLDGL 361
                  .:|..||.:..|.|..:...|||:.::|||.:..|. :|.......:|.:.|:..||.|
Zfish   306 APAQIVEVLKHLVSNNKDMVHDDAPFKFVQLVQLLRVASLEK-IEAIWSQFKDKPVYRRWLLDAL 369

  Fly   362 FRTSTAESARVILKQLSKFDEKEKLLA------------ILSLNIVKSVDKETLNQAAS------ 408
                .|....||:|.:     |||.||            :::|.:| :.|.||:...||
Zfish   370 ----PAVGTPVIIKFI-----KEKFLAGEFTTPEFIQTLVIALQMV-TADPETIKMTASLATHEK 424

  Fly   409 -QLLPNAPKELYIAVGNLVAKYCLK-NYCQGPEIDAISKKFSDGLKHCKPNTKREEERIVYILKG 471
             ..:|...:.:.:..|:|:||||:. ..|....:..|.:..::.:      :|.:...|...||.
Zfish   425 FATIPALREVVMLGYGSLIAKYCVAVPTCPAELLRPIHEIATEAI------SKNDIPEITLALKV 483

  Fly   472 LGNA----------KSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKCEE--TLQSKSLELLK 524
            :|||          |.|.|...||      .....|::|.|:.|...:..:|  .:|..:|:|:.
Zfish   484 MGNAGHPSSLKPIMKLLPGLRTAA------NALPIRVQVDAILALRNIAKKEPKLVQPVALQLVL 542

  Fly   525 NRNEDSELRIEAYLSAISC-PNAEVANQISEIVNSETVNQVGGFISSNLKAIR-----DSTDVSR 583
            :|....|:|:.|.:..... |:..:.:.::..:..|....|..|..|::|::.     |...|:
Zfish   543 DRALHPEVRMVACIVLFEAEPSVALVSSLAGALRIEPNMHVASFAYSHIKSLTRITAPDMASVA- 606

  Fly   584 DQQKYHLANIRV----TKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLPRSSRIN 644
                 ..||:.:    .|...::| |||...::.|....|.:||:....:|......|||:....
Zfish   607 -----GAANVAIKLMSRKLDRLNY-RYSRAFQMDYYYTPLMIGAAGSAYMINDAATILPRAVVAK 665

  Fly   645 VTTEFFGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGGRARRSIV 709
            ......|...:|.|..||...:.:.|        |.:...||                     ..
Zfish   666 ARAYLAGAAADVIEFGVRTGGIHEAL--------LKSPAADE---------------------SA 701

  Fly   710 DDVSKISKKYKMYGVKNVQDLNLD-----VSLKLFGSELAFLSLGDNIPSSLDDIINYFSTSFEK 769
            |.::||  |..:..:.|.:.|..|     ..||:||.|:|:              :|:..|..|:
Zfish   702 DRITKI--KRTLRALTNWKALPTDKPLASAYLKVFGQEVAY--------------VNFDKTIIEE 750

  Fly   770 A-------------KQELSSFEK----QFSSHHLFLDTDLAYPTSIGVPLELVAQGFAATKVDLA 817
            |             |:.|.:.::    |::...|..:.....||::|||:|......|.....:.
Zfish   751 AIPMATGPKPRALLKEALKALQEGVAFQYAKPLLAAEVRRILPTAVGVPMEFSWYTAAVAAASVN 815

  Fly   818 VSLDINAILEQNWQKAKY-RLKFV---------PSVDINANVQIGFN-----AQVLSTG-LRVVS 866
            |...|...|.:..:...| :||..         |||.:.....:|.|     |.|::.| :|.::
Zfish   816 VQATITPALPEKLESMTYEQLKKTDVQFQAEARPSVALQTFAVMGVNTAFIQAAVMARGKIRTIA 880

  Fly   867 SAHSATGSDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNKNS 931
            ....|..:||                                             ||||.| ..:
Zfish   881 PGKVAARADI---------------------------------------------LKGNYK-VEA 899

  Fly   932 QPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSRPFNFAVYLTTERKFT 996
            .|.|:        ..:|...|..:.:.|:....:.|||.:.:..:..|.
Zfish   900 LPVEL--------PEHIASASFETYAVVRNIEDHSAERSVPLVPELSLQ---------------- 940

  Fly   997 FKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHFAVEGGINNDKN 1061
                                 .|:.|:...:..|:.:.....:...||.:.|:
Zfish   941 ---------------------NSQASYAGDLSSEMSSVASVRAPAPFDRTLCY------------ 972

  Fly  1062 ELVVYGQYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNNG--ISNS----INGYHADGKIVVKKNS 1120
             .|.|                    .|.|..:|:..:|.  |.||    |.|:|:....|.:...
Zfish   973 -AVPY--------------------IEIKGCVEVHSHNAAFIRNSTLFYIIGHHSVRAAVARAEG 1016

  Fly  1121 NNIERYNFENFQVSNSNNAHVAVNGWSDVGTNS---LTSELRISLDH----QTFLIKENLKLENG 1178
            ..:||..||                 ..||..:   |..::.|..|.    |.||:|....|:.
Zfish  1017 PAVERLEFE-----------------VQVGPRAAERLVKQINIIDDDTPEGQAFLLKLREILDT- 1063

  Fly  1179 LYEAGFFINDEHSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSDGSFNFQKLADSNSARAGS 1243
              ||      :::|.:...||...:.:..|.:..|:..:::.|..|..|.:...::.|..::..:
Zfish  1064 --EA------KNAPVSSESSSSRNSRSSSSRSTSTSTSSSSSSSSSSSSSSSSSMSSSRMSKTAT 1120

  Fly  1244 LVENVEIQYKNKQVGGIKIMSNFDVNKMDVDVEISREQK---------IGSIIVKYESNQRHAQD 1299
            ::|.....:|::.:.......:..........|..::|.         :.:||.:.....:....
Zfish  1121 IIEPFRKFHKDRYLAHHSATKDTSSGSAAASFEQMQKQNRFLGNDIPPVFAIIARAVRADQKLLG 1185

  Fly  1300 YSLEA-----SAKINKHSIDVISKCDFNGNVYV-VDNSLVT--------SWGT-----LLSAKGE 1345
            |.|.|     :|::..    ::|....|.|:.: .|.:|::        |||.     .:.||.|
Zfish  1186 YQLAAYFDKPTARVQL----IVSSIAENDNMKICADGALLSKHKVTGKFSWGAECKQYAVFAKAE 1246

  Fly  1346 IG 1347
            .|
Zfish  1247 AG 1248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	135/609 (22%)
		DUF1943	605..911	CDD:286281	66/343 (19%)
		DUF1081	932..1031	CDD:283982	11/98 (11%)
		VWD	2789..2931	CDD:214566
vtg1	NP_001038362.3	Vitellogenin_N	24..592	CDD:279663	135/609 (22%)
		DUF1943	626..917	CDD:286281	75/389 (19%)
		DUF1944	1168..1332	CDD:286284	18/85 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910