DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtg6

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001116082.3	Gene:	vtg6 / 559229	ZFINID:	ZDB-GENE-001201-5	Length:	1374	Species:	Danio rerio

Alignment Length:	1636	Identity:	327/1636 - (19%)
Similarity:	583/1636 - (35%)	Gaps:	470/1636 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LIGIL-------ASVL-LTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVP 66
            |.|:|       |.|| ||:|:.|....||        :.::.....|.|.::::|..|    :|
Zfish     2 LSGVLHKPPAMRAVVLALTVALVASQQFNL--------VPEFAHDKTYVYKYEALLLGG----LP 54

  Fly    67 NDS-DDTSLKVSGSAKIFAKGNCGYTLQLSSVKV-----TNTKES------VEKKILNSIQKPVQ 119
            .:. ....:|||...::.|.....|.::|....:     |..|:|      :...:...:|.|::
Zfish    55 QEGLARAGIKVSSKVRLSAMTENTYLMKLMDPLLYEYAGTWPKDSFVPATKLTSALAAQLQIPIK 119

  Fly   120 FTLVSGILEPQICSDSSDLDYSLNIKRAVVSLLQSGIEAE------HEVDVFGMCPTHTSTSKVG 178
            |...:|:: .::.:.:......:|:.|.::::||..::..      .|....|:|.||...::..
Zfish   120 FEYANGVV-GKVFAPAGVSPTVMNLHRGILNILQLNLKKTQNIYELQEAGAQGVCRTHYVINEDP 183

  Fly   179 NAN--IITKARNLNSCSHREQINSGLV-SGKVNEKAGITSSLLLQA--NYIKESRIVNHLIENVQ 238
            ..|  |:||:::|:.|..|...:.||. :.:..|......||:..|  |||.:......||....
Zfish   184 KTNHIIVTKSKDLSHCQERIMKDVGLAYTERCAECTKRVKSLIETATYNYIMKPADNGALIAEAT 248

  Fly   239 LTETYKF--IGNTKRNSDISAK-VVTILKL-KNP-SGTKANSPGTGS---TVRSLIFQRP-ETYT 294
            :.|.|:|  .......:.:.|| .:..::: |.| ...||:....||   ...|.|.|.| :...
Zfish   249 VEEVYQFSPFNEIHGAAMMEAKQTLAFVEIEKTPVVPIKADYMPRGSLQYEFASEILQTPIQLMK 313

  Fly   295 SKNINA-LKTILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAF--PHPNKVLARKV 356
            .|:..| :..:|..||::..|.|..:...|||:.::|||   ..||.::.|.  ...:|.:.|:.
Zfish   314 IKDAPAQIVEVLKHLVENNKDMVHDDAPFKFVQLVQLLR---VVTLDKIEAIWSQFKDKPVYRRW 375

  Fly   357 YLDGLFRTSTAESARVILKQLSKFDEKEKLLA------------ILSLNIVKSVDKETLNQAASQ 409
            .||.|    .|....||:|.:     |||.||            :::|.:| :.|.||:...||.
Zfish   376 LLDAL----PAVGTPVIIKFI-----KEKFLAGEFTTPEFIQTLVIALQMV-TADLETIQMTASL 430

  Fly   410 L-------LPNAPKELYIAVGNLVAKYCLK-NYCQGPEIDAISKKFSDGLKHCKPNTKREEERIV 466
            .       :|...:.:.:..|:|:||:|:. ..|....:..|.:..::.:      :|.:...|.
Zfish   431 AMHEKFVSIPALREVVMLGYGSLIAKHCVAVPTCPAELLRPIHETATEAI------SKNDIPEIT 489

  Fly   467 YILKGLGNA----------KSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKCEE--TLQSKS 519
            ..||.:|||          |.|.|...||      .....|::|.|:.|...:..:|  .:|..:
Zfish   490 LALKVMGNAGHPSSLKPIMKLLPGLRTAA------NALPVRVQVDAILALRNIAKKEPKLVQPVA 548

  Fly   520 LELLKNRNEDSELRIEAYLSAISC-PNAEVANQISEIVNSETVNQVGGFISSNLKAIRDSTDVSR 583
            |:|:.:|....|:|:.|.:..... |:..:.:.::..:.:|....|..|..|::|::   |.::.
Zfish   549 LQLVLDRALHPEVRMVACIVLFETEPSVALISSLAGALRTEPNMHVASFAYSHIKSL---TRITA 610

  Fly   584 DQQKY--HLANIRV----TKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLPRSSR 642
            ....|  ..||:.:    .|...::| |||...::.|....|.:||:....:|......|||:..
Zfish   611 PDMAYVAGAANVAIKLMNCKLDRLNY-RYSRAFQMDYYYTPLMIGAAGSAYMINDAATILPRAVV 674

  Fly   643 INVTTEFFGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGGRARRS 707
            ....|...|...:|.|..||...:.:.|        |.:...||
Zfish   675 AKARTYLAGAAADVVEFGVRTGGINEAL--------LKSPAADE--------------------- 710

  Fly   708 IVDDVSKISKKYKMYGVKNVQDLNLDVSL-----KLFGSELAFLSLGDNIPSSLDDIINYFSTSF 767
            .||.::||.:..|  .:.|.:.|..|..|     |:||.|:|:              :|:..|..
Zfish   711 SVDRITKIKRTLK--ALTNWKALPTDKPLASAYVKVFGQEVAY--------------VNFDKTII 759

  Fly   768 EKA-------------KQELSSFEK----QFSSHHLFLDTDLAYPTSIGVPLELVAQGFAATKVD 815
            |:|             |:.|.:.::    |::...|..:.....||::|||:|......|.....
Zfish   760 EEAIPMVTGPKPRALLKEALKALQEGVAFQYAKPLLAAEVRRILPTAVGVPMEFSWYTAAVAAAS 824

  Fly   816 LAVSLDINAILEQNWQKAKY-RLKFV---------PSVDINANVQIGFN-----AQVLSTG-LRV 864
            :.|...|...|.:..:...| :||..         |||.:.....:|.|     |.|::.| :|.
Zfish   825 VNVQATITPALPEKLESMTYEQLKKTDVQFQAEARPSVALQTFAVMGVNTAFIQAAVMARGKIRT 889

  Fly   865 VSSAHSATGSDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNK 929
            ::....|..:||                                             ||||.|
Zfish   890 IAPGKVAARADI---------------------------------------------LKGNYK-- 907

  Fly   930 NSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNV----AERGLSVSEKFHLSRPFNFAVYLT 990
                       :|.:.:::....:::..|..|...|:    |||.:.:..:..|.
Zfish   908 -----------VEALPVDLPEHIASASFETHAVVRNIEDHSAERSVPLVPQLSLQ---------- 951

  Fly   991 TERKFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFDNSQCHFAVEGG 1055
                      ::|.:.:..|       .|::|.|.:|.          :...||.:.|:
Zfish   952 ----------NSQTSNANDW-------SSEMSPDVSVK----------APAPFDRTLCY------ 983

  Fly  1056 INNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNNG--ISNS----INGYHADGKI 1114
                   .|.|                    .|.|..:|:..:|.  |.||    |.|.|:....
Zfish   984 -------AVPY--------------------IEIKGCVEVHSHNAAFIRNSTLFYIIGQHSAHVA 1021

  Fly  1115 VVKKNSNNIERYNFENFQVSNSNNAHVAVNGWSDVGTNS---LTSELRISLDH----QTFLIKEN 1172
            |.:.....:||..||                 ..||..:   |..::.|..|.    |.||:|..
Zfish  1022 VARAEGPAVERLEFE-----------------VQVGPRAAERLVKQINIIDDDTPEGQAFLLKLR 1069

  Fly  1173 LKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSDGSFNFQKLADSN 1237
            ..|:.   ||.   |...|.|:...|....:|:..|....:|..:::.|..|..|.:...::.|.
Zfish  1070 EILDT---EAK---NAPVSSESSSSSRNSRSISSSSSNSNSNSSSSSSSSSSSSSSSSSSMSSSR 1128

  Fly  1238 SARAGSLVENV----------------------------EIQYKNKQVG---------------- 1258
            .::..:::|..                            ::|.||:.:|
Zfish  1129 MSKTATIMEPFRKFHKDRYLAAHSATKDTSSGSAAASFEQMQKKNRFLGNDIPPVFAIIARAVRA 1193

  Fly  1259 -----GIKIMSNFDVNKMDVDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISK 1318
                 |.::.:.|       |...:|.|.|.|.|.: ..|.:...|     .|.::||.:
Zfish  1194 DQKLLGYQLAAYF-------DKPTARVQLIASSIAE-NDNMKICAD-----GALLSKHKV----- 1240

  Fly  1319 CDFNGNVYVVDNSLVTSWGT-----LLSAKGEIG--QRYSAQDININIQGNVQISGKDKVTQWIL 1376
                        :...|||.     .:.||.|.|  ..|.|..:.:..:...:|     ||.:..
Zfish  1241 ------------TAKFSWGAECKQYAVFAKAEAGVLGEYPAARLEVEWERLPKI-----VTTYAK 1288

  Fly  1377 K----VIGTPDKTNSDFRISRDTSELIKLTSESQHPQDKISFAKLNLIVKNQLTAKGEFRVAKNG 1437
            |    ::.....|...|..:.::.:.|:||:.....:.....|::..|..::........|..|.
Zfish  1289 KLSKCILNAAYDTGFRFEKATNSEKEIELTAALPSQRSLNVIARIPEITMSKRDIYLPVTVPINP 1353

  Fly  1438 KGDFTASIDTL 1448
            .|.|:.:.|.|
Zfish  1354 DGTFSINEDFL 1364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	134/597 (22%)
		DUF1943	605..911	CDD:286281	68/343 (20%)
		DUF1081	932..1031	CDD:283982	14/102 (14%)
		VWD	2789..2931	CDD:214566
vtg6	NP_001116082.3	Vitellogenin_N	35..603	CDD:279663	134/597 (22%)
		DUF1943	637..928	CDD:286281	75/393 (19%)
		DUF1944	1182..1346	CDD:286284	33/198 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910