DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and cv-d

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_732076.1	Gene:	cv-d / 41921	FlyBaseID:	FBgn0265048	Length:	1470	Species:	Drosophila melanogaster

Alignment Length:	1660	Identity:	292/1660 - (17%)
Similarity:	508/1660 - (30%)	Gaps:	563/1660 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YSFDSILTIGASSDVPNDSDDTSLKVSG------------SAKIFAKGNCGYTLQLSSVKVTNTK 103
            |.::..:.:||.   |.|....:...:|            |..:.|.     .|.:..|.:.|:.
  Fly    33 YEYEGNVLVGAK---PQDEGHQAPPTTGWIVRGKLTLQRQSELVLAA-----ALVIDDVTLNNSG 89

  Fly   104 ES-VEKKILNSIQKPVQFTLVSGILEPQICSDSSDLDYSLNIKRAVVSLLQ-----SGIEAEHEV 162
            |. ::.|.:....||.:..|........:.....|..:|:|.|||:.|:||     ||.....|:
  Fly    90 EKFLQNKEMYPPYKPFKIALTKDGAISHVVFKEGDPIWSMNFKRAIASVLQFQMKSSGAFVVDEL 154

  Fly   163 DVFGMCPTHTSTSKVGNANIITKARNLNSC---------------------SHREQI---NSGLV 203
            .:.|.|.|....|...|...|.|...:.:|                     .|::.:   |..:.
  Fly   155 GIHGTCRTEYFVSNRTNYISIRKTPEVKTCKPYSEAVHTTRSNVPPNTCEFDHQKSVIIGNEAIY 219

  Fly   204 SGKVNEKAG-------------------------ITSSLLLQANYIKESRIVNHL-IENVQLTET 242
            ....:.:.|                         |.|.|||  |::.|:.|.|.: ||.....|
  Fly   220 GMSPHNETGYYLSMAHAKGTTLIHTFESTGEAQFINSELLL--NFLNETPIDNPIDIETSMAAE- 281

  Fly   243 YKFIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVRSLIFQRPETYTSKNINALKTI--- 304
                   ..|.::..     |...:|:|  ..||....|    :..:..|.......||:|.
  Fly   282 -------PSNLELQR-----LDPNDPTG--GRSPQQQET----LIAQAGTLLDSLAEALETTEFK 328

  Fly   305 LSDLVDST-GDYVKKETAKKFVEFIRLLRQSD------SETLLELAAFPHPNKVLARKVYLDGLF 362
            .|:..||| .|.:|..:...|....:|.|:.|      .||:              |.::.:.:.
  Fly   329 FSEPYDSTLSDVIKLLSEMDFDSLTKLYREVDIGTSYRQETI--------------RNIFHEIIP 379

  Fly   363 RTSTAESA----RVILKQLSKFDEKEKLLAILSLNIVK---------------SVDKETLNQAAS 408
            |..|..|.    .::|.:|:|.....:||..:..:|.:               ..|:..:.|||.
  Fly   380 RIGTKASVFLTHHLVLNKLTKPQIAVQLLIPMPFHIFELSAELVQKCEDFLNIGPDRPDVRQAAI 444

  Fly   409 QLLPNAPKELYIAVGNLVAKYCLKNYCQGPEIDAISKKFSDGLKHCKPNTKREEERIVYILKGLG 473
            .........:|:|.|  :.|...:.|.|        |.|:..|      :.|:.::.:..|:||.
  Fly   445 LSFATLIHNVYVAKG--IDKEKFEEYVQ--------KYFNAYL------SDRDFDQKMLYLQGLN 493

  Fly   474 NAKSLSGNTVAALSECASTGRSNR-IRVAALHAFSKVKCEETLQSKSLE----LLKNRNEDSELR 533
            |.:  .||....|.........:. ::..|  |::.:...:....:..|    :.::||...|||
  Fly   494 NLQ--LGNVANYLEPIVQDPNEHEDLKFQA--AWTTLALADRRAERIYEVYWPIFESRNASLELR 554

  Fly   534 IEAY-LSAISCPNAEVANQISEIVNSETVNQVGGFISSNLKAIRDST----DVSRDQQKY---HL 590
            :.|. |..||.|.|.....|..|:.|||...:..:..:.:.:|.::|    ...|....|   ||
  Fly   555 VAAVTLLLISNPTAARLISIHRIIQSETDPHMINYYRTTVTSISETTYPCYQHLRRLLSYMHRHL 619

  Fly   591 -----ANIRVTKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLPRSSRINVTTEFF 650
                 :...||..:..|||...|           |:||.....::......:|..:.....||..
  Fly   620 PQKPESRYWVTGNYIFDYRDSKF-----------GIGAMLQVFLVGDPKSDMPVVAFFKFDTEAL 673

  Fly   651 GTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIVKLIEVGNNGVAAGGRARRSIVDDVSKI 715
            |             .....|..|:..:||.    |.|:..:: ..||
  Fly   674 G-------------KFTGQLALYIKARGLP----DTILNKMQ-SRNG------------------ 702

  Fly   716 SKKYKMYGVK-----------NVQDLNLDVSLKLFGSELAFLSLG---------DNIPSSLDDII 760
            |..:....:|           |.:||:|:..|::.|..:....|.         |||...:..||
  Fly   703 SDPFTFKSIKALLAMLQAPIINSKDLHLEFILQMEGKTVLSYYLNQRMFRQLTYDNILERMQQII 767

  Fly   761 NYFSTSFEKAKQELSSFEKQFSSHHLFLDT-------DLAYPTSIGVPLELVAQGFAATKVDLAV 818
            .                    :..|:.:.|       ....||.:|...:::.|....|
  Fly   768 R--------------------TDSHINMQTVRWPFMNRYTVPTVLGTSSDVLLQTTVLT------ 806

  Fly   819 SLDINAILEQNWQKAKYRLKFVPSVDINANVQIGFNAQVLSTGLRVVSSAHSATGSDITVAVISD 883
            ||..|...::|....|:.|:                          :.:.:|:..|   |...|.
  Fly   807 SLRGNITEQRNSPITKHTLE--------------------------IDARYSSYAS---VRSRSY 842

  Fly   884 GEGFNVDLELPREKLELINFNVDTELYVAE-------------QDKQKAIALKGNKKNKN----S 931
            ....|:|.|:.||:..||.....:||::.|             |:....::.|.....|.    :
  Fly   843 NPFLNLDHEINREQGFLIYIPFSSELHLNESGSKCRRYSFSRPQNLTSGLSFKSRAVTKTRGLIT 907

  Fly   932 QPSEICFNQL---------------ELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKF---- 977
            :.:...|.::               .:..|.:.:..:|:|:|:      :..||:.:..:|
  Fly   908 KTAAAPFEEIMVPEGRNDVVQLFSYPMTDLGVRLSMTTNLNEL------IKYRGMLLKSEFTENG 966

  Fly   978 ----------------------HLSRPFNFAVYLTTERKFTFKG--------------------- 999
                                  ||....||.:.:..|:....:|
  Fly   967 FSGNMVVNALMYIFGFTQLSSIHLGHDRNFTMLMYNEKNTRIEGNFCAEDVLKTSDMKGKQIGLT 1031

  Fly  1000 ---------IHTQEAFSQKWKLDYSTPGSKVSH-----------------DTTVVYELGNKPKTF 1038
                     .|..:|. .:|.:......|..|:                 |.....:|..:|..|
  Fly  1032 LEHTDHMNENHAADAL-HRWNITLDVLASTKSNWFKLTGQVQRNSKDDEDDWKACTKLTYEPLVF 1095

  Fly  1039 SRLSFDNSQCHFAVEGGINNDKNELVVYGQYEQDKEI--KKSKIGFSKNGNEYKPLIEIQDNNGI 1101
            ::....           :|.|    ||:|...::.|.  |.|.:.|:...             |.
  Fly  1096 TKRPHT-----------LNGD----VVFGLATEESECPEKGSTVQFAARA-------------GP 1132

  Fly  1102 SNSINGYHADGKI-----------VVK----KNSNNIERYNFENFQVSNSNNAHVAVN---GWSD 1148
            |.....:....||           |:|    ..|...:|.|||||......:..:..:   .|.:
  Fly  1133 SEHARAFLRSDKISLTDTDFCPKEVLKFSPIPTSRYCKRSNFENFTSITQYDMDLKFDNMPAWFE 1197

  Fly  1149 VGTNSLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSYALKT 1213
            :.:|        .|||....:..:.            ::..|..:.|   :|.:......:.|..
  Fly  1198 LWSN--------RLDHLVSALSADK------------VDSLHMSQEI---NISMQTPQDQFRLAV 1239

  Fly  1214 NGKAAAWSIGS-------DGSF--NFQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFD-- 1267
            ......|....       |..|  :.:...||...|:.|::..              |::.||
  Fly  1240 EVNGVKWRFHQIPFFYKLDSKFDASHELTFDSGLKRSCSVING--------------IVNTFDDY 1290

  Fly  1268 -VNKMDVDV----------EISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDF 1321
             :|..::.|          :.|...:| ::.|.....|..:.:|.|...          |.:..|
  Fly  1291 LINLREIAVRPDCLTLLVADCSPLPQI-AVFVTPSPVQGLSTNYGLRVH----------IGQNYF 1344

  Fly  1322 NGNVYVVDNSLVTSWGTLLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTN 1386
            |......::||.|....|:         |..||   ....||    :.|..||       |.:|:
  Fly  1345 NFRARTDNSSLPTDEPVLI---------YLNQD---QTPHNV----RKKPYQW-------PIETS 1386

  Fly  1387 S-DFRISRDTSELIKLTSESQHPQDKISFAKLNLI 1420
            . |||:..:...:  |..|.......|.|...|::
  Fly  1387 DYDFRVELNEQNI--LIVECTQLSSTIQFDLYNIL 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	124/624 (20%)
		DUF1943	605..911	CDD:286281	56/332 (17%)
		DUF1081	932..1031	CDD:283982	20/186 (11%)
		VWD	2789..2931	CDD:214566
cv-d	NP_732076.1	LPD_N	28..589	CDD:214755	124/618 (20%)
		DUF1943	632..>813	CDD:286281	43/253 (17%)
		VWD	1277..1435	CDD:295339	37/193 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4338
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840