DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vit-3

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001367903.1	Gene:	vit-3 / 24104675	WormBaseID:	WBGene00006927	Length:	1603	Species:	Caenorhabditis elegans

Alignment Length:	1769	Identity:	341/1769 - (19%)
Similarity:	649/1769 - (36%)	Gaps:	462/1769 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILASVLLTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDSDDTSLKVS 77
            |:.:.|:.:|:.|.       |..|.   .:.|.:.|.|.||.:|..|..:..   ||.:...:|
Worm     4 IIIASLVALAIAAS-------PALDR---TFSPKSEYVYKFDGLLLSGLPTTF---SDASQTLIS 55

  Fly    78 GSAKIFAKGNCGYTLQLSSVKVTNTK----------ESVEKKILNS-----IQKPVQFTLVSGIL 127
            ...::.|..:....|||..::.:.:.          :|:|::.|:.     ::.|.:..:.:|::
Worm    56 CRTRLQAVDDRYIHLQLIDIQYSASHIPQSEQWPKIKSLEQRELSDELKELLELPFRAQIRNGLV 120

  Fly   128 EPQICSDSSDLDYSLNIKRAVVSLL--------------QSGIEAE--------HEVDVFGMCPT 170
            . :|...|.|.::|.|.||::::|.              |..:|::        ||..:.|.|..
Worm   121 S-EIQFSSEDAEWSKNAKRSILNLFSLRKSAPVDEMSQDQKDMESDKDSLFFNVHEKTMEGDCEV 184

  Fly   171 HTSTSKVGNANIITKARNLNSCSHREQINSGLVSG---KVNEKAGITSSLLLQANYIKESRIVNH 232
            ..:..:.|...|.||:.|.:.|..|.:...||..|   |..||.|         .::|...:..:
Worm   185 AYTIVQEGEKTIYTKSVNFDKCITRPETAYGLRFGSECKECEKEG---------QFVKPQTVYTY 240

  Fly   233 LIENVQLTE-------TYKFIGNTKRNSDISAKVVTI------LKLKNPSGTKANSPGTGSTVRS 284
            ..:|.:|.|       |....|.....|:..:||..:      .::|..||.|.....:... ..
Worm   241 TFKNEKLQESEVHSIYTLNVNGQEVVKSETRSKVTFVEESKINREIKKVSGPKEEIVYSMEN-EK 304

  Fly   285 LIFQRPETYTSKNINALKTILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAFPHPN 349
            ||.|..:......:|..|.|           ..::..::..|..|.:::.:..|       |...
Worm   305 LIEQFYQQGDQAEVNPFKAI-----------EMEQKVEQLDEIFRQIQEHEQNT-------PETV 351

  Fly   350 KVLARKVYLDGLFRTSTAESARVILKQL-SKFDEKEKLLAILSL----------NIVKSVDKETL 403
            .::||.|   .:||..|.|..:.:...: :|.::|.:|:...:|          :::...:|:::
Worm   352 HLIARAV---RMFRMCTIEELKKVHTTIYTKAEKKVQLVIETTLAVAGTKNTIQHLIHHFEKKSI 413

  Fly   404 NQ-AASQLLPNAPKELY-----------IAVGNLVAKY-CLKN---YCQGPEIDAISKKFSDGLK 452
            .. .|::||.:..:.||           :|...|..|| .|:.   ...|..:...:.|..| |.
Worm   414 TPLRAAELLKSVQETLYPSEHIADLLIQLAQSPLSEKYEPLRQSAWLAAGSVVRGFASKTQD-LP 477

  Fly   453 HCKPNTKREEERIVYI-----------------LKGLGNAK-SLSGNTVAALSECASTGRSNRIR 499
            ..:|.:::.:|:.|.:                 ||.||||. .||...:..|.:......|  ||
Worm   478 LIRPASRQTKEKYVRVFMQHFRNADSTYEKVLALKTLGNAGIDLSVYELVQLIQDPRQPLS--IR 540

  Fly   500 VAALHAFSKVK--CEETLQSKSLELLKNRNEDSELRIEAYLSAI-SCPNAEVANQISEIVNSETV 561
            ..|:.|...:|  ....:|...|.:.|||....|||:.|....: :.|...|...|...:.:|:.
Worm   541 TEAVDALRLLKDVMPRKIQKVLLPVYKNRQNKPELRMAALWRMMHTIPEEPVLAHIVSQMENESN 605

  Fly   562 NQVGGFISSNLKAIRDSTDVSRDQQKYHLANIRV-TKTFPVDYRRYSFNNEVSYKLESLGVGAST 625
            ..|..|..:.|:....||:....|.....:.:.: |:..|.:....:::....:..|.|. |...
Worm   606 QHVAAFTYNVLRQFSKSTNPCYQQLAVRCSKVLLFTRYQPQEQMLSTYSQLPLFNSEWLS-GVQF 669

  Fly   626 DYQIIYSQHGFLPRSSRINVTTEFFGTNYNVFEASV--RQENVEDVLEYYLGPKGLVNKDFDEIV 688
            |:..|:.::.|||:..:.:..| .||.|:|.:.|.|  .|:|.|.|:...|....|..|..||:
Worm   670 DFATIFEKNAFLPKEVQASFET-VFGGNWNKYFAQVGFSQQNFEQVILKTLEKLSLYGKQSDEL- 732

  Fly   689 KLIEVGNNGVAAGGRARR--SIVDDVSKISKKYKMY-GVKNVQDLNLDVSLKLFGSELAFLSLGD 750
                          |:||  |.:..:.:|.||..:. .|:.....|......|...|:.::.|..
Worm   733 --------------RSRRVQSGIQMLQEIVKKMNIRPRVQQTDSQNAHAVFYLRYKEMDYIVLPI 783

  Fly   751 NIPSSLDDIINYFSTSFEKAKQELSSF---EKQFSSHH--LFLDTDLAYPTSIGVPLELVAQGFA 810
            :: .::|:::..:..:.|...:.|.:|   :.:|..|.  .|.:.:...||:||:||.:
Worm   784 DM-ETIDNVVEKYVRNGEFDIKSLLTFLTNDSKFELHRALFFYEAERRIPTTIGMPLTI------ 841

  Fly   811 ATKVDLAVSLDINAILEQNWQKAKYRLKFVPSVDINANVQIGFNAQVLSTGLRVVSSA--HSATG 873
            :.|:...:|::....:|.....|:..|..||:|......::.|...|:..|::.:.||  |:...
Worm   842 SGKMPTILSINGKVSIELEKLGARLVLDIVPTVATTHVTEMRFWYPVIEQGVKSLQSARLHTPLR 906

  Fly   874 SDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGN-------KKNKNS 931
            .:.||             ||.:..||:      |..:|..::|:..:::...       .||::|
Worm   907 FESTV-------------ELKKNTLEI------THKFVVPENKKTTVSVHTRPVAFIRVPKNQDS 952

  Fly   932 Q----------------PSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERG-----LSVSE 975
            :                .:|....|.|..||.|            ...|||..:.     |...:
Worm   953 EYVETEEKTISHSQYQMSTEEIDRQYETFGLRI------------NAQGNVLSQWTLPMVLMTEQ 1005

  Fly   976 KFHL-----SRPFNFAVYLT---------TERKF------------------------TFKGIHT 1002
            .|..     :||..|...:|         :|.||                        ..:.|.:
Worm  1006 DFEFTLENKNRPVEFTARVTIGNLEKTDLSEIKFDKIFEKEFDLENNESENRRQYFHKMIREIQS 1070

  Fly  1003 QEAFS-----------------------QKW----KLDYSTPGSKVSHDT---TVVYE-LGNKPK 1036
            ::.|.                       .||    |::.....|.:.|:.   |:..| |..:|:
Worm  1071 EQGFKNLITLKLEAPQQMYWNTELRTVCDKWIRMCKVEMDARRSPMEHENKEWTLRTELLAARPQ 1135

  Fly  1037 TFSRLSFDNSQCHFAVEGGIN-----NDKNELVVYGQYEQDKEIKKSKIGFSKNGN-------EY 1089
            ..|.|.....|.|..|:..:|     :.|:|:....|.||..|.||    |.:|..       ||
Worm  1136 MPSSLRQLREQPHREVQLALNAKWGSSKKSEITFNAQLEQSTEQKK----FLRNIEREYKGIPEY 1196

  Fly  1090 KPLIEIQDNNGISNSINGYH--ADGKIVVKKNSNNIERYNFENFQVSNSNNAHVAVNGWSDVGTN 1152
            :.||:....|.: |.::.|.  .:.:....:..:.|:.|||                 |:
Worm  1197 ELLIKAARLNQV-NVVSEYKLTPESEYTFSRIFDLIKAYNF-----------------WT----- 1238

  Fly  1153 SLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPE--NIYGSSIHL-TIADQSYALKTN 1214
              .||.|:..:.:..:::.:::..:..|........|...|  |:....:.| |||.::...:|.
Worm  1239 --VSEKRVQNEDRRVVLQLSVEPLSRQYMNMTIQTPEQEVELKNVRIPRVVLPTIARRAMFQQTW 1301

  Fly  1215 GK-AAAWSIGSDGSFNFQKLA---------------DSNSARAGSLVENVEIQYKNKQVGGIKIM 1263
            .| .|...:|......|..:.               .|...|...|.:.:.   ||.:...:|:
Worm  1302 EKTGATCKVGQSEVSTFDNVIYRAPLTTCYSLVAKDCSEQPRFAVLAKKIN---KNSEELLVKV- 1362

  Fly  1264 SNFDVNKMDVDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVYVV 1328
                         :.||::|  ::.|.:.......|.......::.:::|:::.
Worm  1363 -------------VRREEEI--VVKKSDDKFLVKVDEKKVNPTELEQYNIEILG----------- 1401

  Fly  1329 DNSLVTSWGTLLSAKGEIGQRYSAQDININ---IQGNVQISGKDKVTQWILKVIGTPD-KTNSDF 1389
            ||.:|     :....||:  |:....:..|   :....|:.|          :.|..| :.:::|
Worm  1402 DNLIV-----IRLPHGEV--RFDGYTVKTNMPSVASQNQLCG----------LCGNNDGERDNEF 1449

  Fly  1390 RISRDTSELIKLTSESQHPQDKISFAKLNLIVKNQ--------LTAKGEFRVAKN---GKGDFTA 1443
                       :|:::...:|...|.: :.::||:        ::.|..:|...|   .|.|:.:
Worm  1450 -----------MTADNYETEDVEEFHR-SYLLKNEECEVENDRISEKKNYRNKWNREEKKSDYVS 1502

  Fly  1444 SIDTLKT--EPKHKLEIESKFHIQSPKYDIDASLTLDGKRKVHLKSENTI-EKLKFS-----TKN 1500
            |.|....  |.:.:.::..|..|:.....:..|:....:.:..|:||.|. ||::|:     :||
Worm  1503 SSDYENNYDEKETENQLFKKTLIKEFSNRVCFSIEPVSECRRGLESEKTSNEKIRFTCMPRHSKN 1567

  Fly  1501 ----IGEANDKIIA 1510
                :.||.::.:|
Worm  1568 ARRFLKEAREQTVA 1581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	129/630 (20%)
		DUF1943	605..911	CDD:286281	70/317 (22%)
		DUF1081	932..1031	CDD:283982	27/188 (14%)
		VWD	2789..2931	CDD:214566
vit-3	NP_001367903.1	Vitellogenin_N	24..617	CDD:396081	129/630 (20%)
		DUF1943	651..936	CDD:401204	72/327 (22%)
		VWD	1300..1454	CDD:214566	30/211 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910