Protein Alignment apolpp and vit-1

DIOPT Version :9

• Sequence 1: NP_001259085.1
• Gene: apolpp / 43827
• FlyBaseID: FBgn0087002
• Length: 3351
• Species: Drosophila melanogaster
• Sequence 2: NP_001367671.1
• Gene: vit-1 / 181034
• WormBaseID: WBGene00006925
• Length: 1616
• Species: Caenorhabditis elegans
• Alignment Length: 1765
• Identity: 332/1765 - (18%)
• Similarity: 654/1765 - (37%)
• Gaps: 471/1765 - (26%)

  Fly    13 ILASVL-LTIAVNA--ENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDSDDTS- 73
            |:||:: |.||.:.  |....   ||.|           |.|.||.::..|    :|..|.:.|
 Worm     5 IIASIVALAIAFSPAFERTFE---PKID-----------YHYKFDGLVLSG----LPTASSELSQ 51

  Fly    74 LKVSGSAKIFAKGNCGYTLQLSSVKV--TNTKESVEKKILNSIQK-------------PVQFTLV 123
            .:.|...:|.|..:....|||.::.:  ::..||.:...|||:::             |::..|.
 Worm    52 SRFSARVRIQAVDDRHIHLQLVNIHMAASHLPESEQIPSLNSMEQRELSEEYKQMLKLPLRAQLR 116

  Fly   124 SGILEPQICSDSSDLDYSLNIKRAVVSL--------------LQSGIEAE-----------HEVD 163
            :|:: .::..|..|.::|.|:|||||::              ::|..:.|           :|..
 Worm   117 NGLI-AELQFDKEDAEWSKNMKRAVVNMISFNPIAPRNEIEKIESSYDKEEQSEENTSFFTNEKT 180

  Fly   164 VFGMCPTHTSTSKVGNANIITKARNLNSCSHREQINSGL-VSGKVNEKAGITSSLLLQANYIKES 227
            :.|.|....:..:.....||||:.|.:.|:.|.:|..|| .|.:..|....|.       .|:..
 Worm   181 LEGDCQVAYTVIREQKKTIITKSINFDKCTERSEIAYGLRYSSECPECEKDTV-------LIRPQ 238

  Fly   228 RIVNHLIENVQLTE-------TYKFIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVRSL 285
            .:..:::||.:|.|       |....|.....::..:|:|    |:.....|::.........|:
 Worm   239 TVYTYILENEELKESEVRSLYTVNVNGQEVMKTETRSKLV----LEENHSIKSHIEKVNGEKESI 299

  Fly   286 IFQRPETYTSKNINALKTILSDLVDSTGDYVKKETAKKFVEFIRL-------LRQSDSETLLELA 343
            |      |:|:        ...||:   |:.|.....:|..|.:.       |.::.:|.:.|:.
 Worm   300 I------YSSR--------WEQLVE---DFFKNGDKAEFAPFEKFPLDKKMHLIKTITEQIQEVE 347

  Fly   344 -AFPHPNKVLARKVYLDGLFRTSTAESARVILKQL-SKFDEK-----EKLLAIL-SLNIVKSV-- 398
             ..|..:..|||.|   .:|||::....:.|.:.| .|.|:|     |..|||. :.|.::.:
 Worm   348 NNIPETSHFLARLV---RIFRTTSTSQLKEIHETLYVKADKKIQSLMEHALAIAGTKNTIQHILV 409

  Fly   399 ---DKETLNQAASQLLPNAPKELYIA--VGNLVAKYCLKNYCQGPEIDAISKKFSDG-------- 450
               :::.:...|:|||.:..:..:.:  :...:.|:......:..::...|...:.|
 Worm   410 HIENEDIVPLEAAQLLKSIQETPFPSQTIAEALIKFAESRVSKNNQVVRQSAWLAAGSVVRGIVD 474

  Fly   451 LKHCKPNTKREEERI---------------------VYILKGLGNA-KSLSGNTVAALSECASTG 493
            .|:.:|..:.::..:                     :..||.:||| ..:|.|   .|:|.....
 Worm   475 YKNIRPLVREDKRELKEKFLRVFMQQYKDAETTYEKILALKSIGNAGLDISVN---QLNEIIVDK 536

  Fly   494 RS-NRIRVAALHAFSKVK--CEETLQSKSLELLKNRNEDSELRIEAYLSAI-SCPNAEVANQISE 554
            |. ..:|..|:.|...:|  ....:|...|.:.|||..:.|:|:.|....: :.|...:..|:..
 Worm   537 RQLLPVRKEAIDALRLLKDTMPRKIQKVLLPIYKNRQYEPEIRMLALWRMMHTRPEESLLVQVVS 601

  Fly   555 IVNSETVNQVGGFISSNLKAIRDSTDVSRDQQKYHLANIRVTKTFPVDYRRYSFNNEV---SYK- 615
            .:..||..||.......::....||:..     |....|..:|.  :.:.||....::   ||.
 Worm   602 QMEKETNQQVAALTHQMIRHFAKSTNPC-----YQRVAIVCSKV--LSFTRYQPQEQMIASSYAQ 659

  Fly   616 ----LESLGVGASTDYQIIYSQHGFLPRSSRINVTTEFFGTNYNVFEASV--RQENVEDVLEYYL 674
                |::...||..|:..|:.::.||.:....::.. .||.|:|.:.|.:  .|::::..::..|
 Worm   660 LPLFLQNSFSGAQFDFAAIFEKNSFLLKDLHASLDA-VFGGNWNKYFAQIGFSQQHMDKYVQMAL 723

  Fly   675 GPKGLVNKDFDEIV--KLIEVG-----NNGVAAGGRARRSIVDDVSKISKKYKMYGVKNVQDLNL 732
            .....:.|:...:|  :.|:.|     ...:....|||.:..::....:..|..|...:...|.:
 Worm   724 EKLESIEKESTTVVRGRRIQTGITLLKELALKMNIRARPANYNEKDAFAMVYLRYKDMDYAILPV 788

  Fly   733 DVSLKLFGSELAFLSLGDNIPSSLDDIINYFSTSFEKAKQELSSFEKQFSSHH--LFLDTDLAYP 795
            |..|               |...::..|:.....|.:.::.|:. |.:|.:||  .|.:....:|
 Worm   789 DTQL---------------IEKLIEKYISNGKVQFSEIRRLLNQ-EHEFETHHAAYFYEAIRKFP 837

  Fly   796 TSIGVPLELVAQGFAATKVDLAVSLDINAILEQNWQKAKYRLKFVPSVDINANVQIGFNAQVLST 860
            |::|:|  |:..|    |:....|.:....|.....:.:..::..|||......::.....:...
 Worm   838 TTLGLP--LIVSG----KIPTVFSAEGQFSLGLEETELRLTVEARPSVAATHVYEMRMFTPLFEQ 896

  Fly   861 GLRVVSSAHSATGSDITVAVISDGEGFNV--DLELPREKLELINFNVDTELYV----------AE 913
            |::.|.|..:.|...|. ||:.....|.:  .:.:|..:..:|:......:::          .|
 Worm   897 GVKSVQSVRAYTPIKIQ-AVVGMKRNFEIVYKVVVPENQKSIISLTTRPVVFLRFPGFSKFEYIE 960

  Fly   914 QDKQKAIALKGNKKNKNSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERG--LSVSEK 976
            .:::..:..:..:|   :|..|..||   .:||.:..:.:. |::....|..:||:.  :||..|
 Worm   961 AEERTVVVPQWQQK---TQEIEKVFN---FLGLEVSTRGNI-LNQHTLENWLLAEQDFEVSVENK 1018

  Fly   977 FHLSRPFNFAVYLTTER--KFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVV----------- 1028
            :   ||..|...||..:  |.....|...:.|.::::|:.....|:..:.|.:|
 Worm  1019 Y---RPAEFTARLTVGQLEKTELSQIKYNKIFEKEFELEQENTESRREYFTKMVKSIQKEQGYKS 1080

  Fly  1029 -----------YELGN----------------------------------------KPKTFSRLS 1042
                       |.:..                                        :|:..|.|.
 Worm  1081 VVSLRLEAPRDYTMNTEVTTVCDKQVRMCQWEVEIRRSPILEETKEWTLRSQLLVVRPEMPSSLR 1145

  Fly  1043 FDNSQCHFAVEGGI-----NNDKNELVVYGQYEQDKEIKKSKIGFSKNGN---EYKPLIEIQDNN 1099
            ..:.|.|..|:..:     :..|:|:.|..|.:|.||.||.:....::.|   ||:.||:....|
 Worm  1146 QLHDQPHREVQLSLTSTWGSQKKSEVTVNAQLQQSKEQKKYERNMDRHFNGMPEYELLIKAARLN 1210

  Fly  1100 GISNSINGYH--ADGKIVVKKNSNNIERYNFENFQVS----NSNNAHVAVNGWSDVGTNSLT--- 1155
            .| |::..|.  .:.:.|:.:..:.::.||:  :.||    |:.|..|.|         .||
 Worm  1211 QI-NAVAEYKLTRETEQVLARYFDLVKAYNY--WTVSSRPENNENDRVVV---------QLTVEP 1263

  Fly  1156 -SELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHL-TIADQSYALKTNGKAA 1218
             |...:::..|:.:.:..||                   |:....::| :||.:|.....|  .|
 Worm  1264 MSRQYVNITMQSPIERVELK-------------------NVQVPRVYLPSIAQRSVKHLLN--EA 1307

  Fly  1219 AWSI----------GSDGSFN------FQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFD 1267
            :.|:          ..|..:|      :..:|...|......|.:.:.: ||.:...||::.
 Worm  1308 SGSVCKVQKNQIRTFDDVLYNTPLTTCYSLIAKDCSEEPTFAVLSKKTE-KNSEEMIIKVIR--- 1368

  Fly  1268 VNKMDVDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCD-----------F 1321
             .:.::..::..|:    |.||.:..:..::|||        .|.|:.:.:.|           |
 Worm  1369 -GEQEIVAQLQNEE----IRVKVDGKKILSEDYS--------AHQIERLGESDIVIELPEGEVRF 1420

  Fly  1322 NGNVYVVDNSLVTSWGTLLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTN 1386
            :|  |.:...|.:               ||.::....:.||                  ..|::.
 Worm  1421 DG--YTIKTQLPS---------------YSRKNQLCGLCGN------------------NDDEST 1450

  Fly  1387 SDFRISRDTSELIKLTSESQHPQDKISFAKLNLIVKNQLTAKGEFRVAKNGKGDFTASIDTLKTE 1451
            ::|           .||::...:|...|.: :.::||:.....|.|:::.            |..
 Worm  1451 NEF-----------YTSDNTETKDIEEFHR-SYLLKNEECEAEEERLSEK------------KNY 1491

  Fly  1452 PKH-KLEIESKFHIQSPKYDIDASLTLDGKRKVHLKSE---NTIEKLK---------FSTKNIGE 1503
            .|: :.:.||:.:.....||.:...|  .|::.:.:|:   :.:||.:         ||.:.:.|
 Worm  1492 RKYDERKYESEEYSFEETYDYEQENT--NKKQKNQRSQKKSDLVEKTQIKEFSHRICFSVEPVAE 1554

  Fly  1504 ANDKIIAFEA 1513
            ...:  .:||
 Worm  1555 CRRR--GYEA 1562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	128/634 (20%)
		DUF1943	605..911	CDD:286281	61/326 (19%)
		DUF1081	932..1031	CDD:283982	26/124 (21%)
		VWD	2789..2931	CDD:214566
vit-1	NP_001367671.1	Vitellogenin_N	24..620	CDD:396081	131/648 (20%)
		DUF1943	655..940	CDD:401204	59/308 (19%)
		VWD	1301..1458	CDD:214566	34/221 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910