Protein Alignment apolpp and vit-2

DIOPT Version :9

• Sequence 1: NP_001259085.1
• Gene: apolpp / 43827
• FlyBaseID: FBgn0087002
• Length: 3351
• Species: Drosophila melanogaster
• Sequence 2: NP_508868.1
• Gene: vit-2 / 180781
• WormBaseID: WBGene00006926
• Length: 1613
• Species: Caenorhabditis elegans
• Alignment Length: 1731
• Identity: 335/1731 - (19%)
• Similarity: 648/1731 - (37%)
• Gaps: 465/1731 - (26%)

  Fly    34 PKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDSDDTS-LKVSGSAKIFAKGNCGYTLQLSSV 97
            ||:|           |.|.||.::..|    :|:.|.:.| .::|..|:|.|..:....|||.::
 Worm    26 PKTD-----------YHYKFDGLVLSG----LPSASSELSQSRISARARIQAVDDRYIHLQLVNI 75

  Fly    98 KV--TNTKESVEKKILNSIQK-------------PVQFTLVSGILEPQICSDSSDLDYSLNIKRA 147
            ::  ::..||.:...|||:::             |::..|.:|::. ::..|..|.::|.|:|||
 Worm    76 RMAASHLPESEQMPSLNSMEQRELSEEYKQMLELPLRAQLRNGLIS-ELQFDKEDAEWSKNMKRA 139

  Fly   148 VVSL--------------LQSGIEAE-----------HEVDVFGMCPTHTSTSKVGNANIITKAR 187
            ||::              ::|..:.|           :|..:.|.|....:..:.....||||:.
 Worm   140 VVNMISFNPIAPRNEIEKIESSYDKEEQSEENTSFFTNEKTLEGDCQVAYTVIREQKKTIITKSI 204

  Fly   188 NLNSCSHREQINSGL-VSGKVNEKAGITSSLLLQANYIKESRIVNHLIENVQLTE-------TYK 244
            |.:.|:.|.:|..|| .|.:..|....|       ..|:...:..:::||.:|.|       |..
 Worm   205 NFDKCTERSEIAYGLRYSSECPECEKDT-------ELIRPQTVYTYVLENEELKESEVRSLYTVN 262

  Fly   245 FIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVRSLIFQRPETYTSKNINALKTILSDLV 309
            ..|.....::..:|:|    |:.....|::.........|:|      |:|:        ...||
 Worm   263 VNGQEVMKTETRSKLV----LEENHSIKSHIKKVNGEKESII------YSSR--------WEQLV 309

  Fly   310 DSTGDYVKKETAKKFVEFIRL-------LRQSDSETLLELA-AFPHPNKVLARKVYLDGLFRTST 366
            :   |:.|.....:|..|.:.       |.::.:|.:.|:. ..|..:..|||.|   .:|||::
 Worm   310 E---DFFKNGDKAEFAPFEKFPLDKKMHLIKTITEQIQEVENNMPETSHFLARLV---RIFRTTS 368

  Fly   367 AESARVILKQL-SKFDEK-----EKLLA-------------------ILSLNIVKSVDKET---L 403
            ....:.|.:.| .|.|:|     |..||                   ||.|..:....:||   .
 Worm   369 TSQLKEIHETLYVKADKKIQSLMEHALAIAGTKNTIQHILVHMENEDILPLGQILKTIQETPFPS 433

  Fly   404 NQAASQLLPNAPKELYIAVGNLVAKYCLKNYCQGPEIDA--ISKKFSDGLKHCKPNTKREEERI- 465
            ...|..|:..|  |..:|..|||.:       |...:.|  :.:...| .|:.:|..:.::..:
 Worm   434 QSIAEALIKFA--ESRVAKNNLVVR-------QAAWLAAGSVVRGIVD-YKNIRPLVREDKRELK 488

  Fly   466 --------------------VYILKGLGNA-KSLSGNTVAALSECASTGRSN-RIRVAALHAFSK 508
                                :..||.:||| ..:|.|   .|:|.....|.. .:|..|:.|...
 Worm   489 EKFLRVFMQQYKDAETTYEKILALKTIGNAGLDISVN---QLNEIIVDKRQPLPVRKEAIDALRL 550

  Fly   509 VK--CEETLQSKSLELLKNRNEDSELRIEAYLSAI-SCPNAEVANQISEIVNSETVNQVGGFISS 570
            :|  ....:|...|.:.|||..:.|:|:.|....: :.|...:..|:...:..||..||......
 Worm   551 LKDTMPRKIQKVLLPIYKNRQYEPEIRMLALWRMMHTRPEESLLVQVVSQMEKETNQQVAALTHQ 615

  Fly   571 NLKAIRDSTDVSRDQQKYHLANIRVTKTFPVDYRRYSFNNEV---SYK-----LESLGVGASTDY 627
            .::....||:..     |....|..:|.  :.:.||....::   ||.     |::...||..|:
 Worm   616 MIRHFAMSTNPC-----YQRVAIVCSKV--LSFTRYQPQEQMIASSYAQLPLFLQNSFSGAQFDF 673

  Fly   628 QIIYSQHGFLPRSSRINVTTEFFGTNYNVFEASV--RQENVEDVLEYYLGPKGLVNKDFDEIVKL 690
            ..|:.::.|||:....::.. .||.|:|.:.|.:  .|::::..::..|.....:.|:...:|:
 Worm   674 AAIFEKNSFLPKDLHASLDA-VFGGNWNKYFAQIGFSQQHMDKYVQMALEKLESLEKESTTVVR- 736

  Fly   691 IEVGNNGVAAGGRARRSIVDDVSKISKKYKM------YGVKNVQDLNLDVSLKLFGSELAFLSLG 749
                       ||..::.:..:.::::|..:      |..|   |....|.|:....:.|||.:.
 Worm   737 -----------GRRIQTGIKLLKELAQKMNIRARPATYTEK---DAFAMVYLRYKDMDYAFLPID 787

  Fly   750 DNIPSSLDDIINYFSTS----FEKAKQELSSFEKQFSSHH--LFLDTDLAYPTSIGVPLELVAQG 808
            ..:   ::::|..|:::    |.:.::.|:. |.:|.:||  .|.:....:||::|:||.:
 Worm   788 RQL---VENLIEKFTSNGKVQFSEIRRLLNQ-ELEFETHHAAYFYEAIRKFPTTLGLPLTI---- 844

  Fly   809 FAATKVDLAVSLDINAILEQNWQKAKYRLKFVPSVDINANVQIGFNAQVLSTGLRVVSSAHSATG 873
              :.|:...:|.:....||....:.:..::..|||......::.....:...|::.|.|..:.|.
 Worm   845 --SGKIPTVISAEGQFSLELEGTELRLTVEARPSVAATHVYEMRMFTPLFEQGVKSVQSVRAYTP 907

  Fly   874 SDITVAVISDGEGFNV--DLELPREKLELINFNVDTELYV----------AEQDKQKAIALKGNK 926
            ..|. ||......|.:  .:.:|..:..:::......:::          .|.:::..:..:..:
 Worm   908 IKIQ-AVAGMKRNFEIVYKVVVPENQKSIVSLTTRPVVFLRFPGFSKFEYIEAEERTVVVPQWQQ 971

  Fly   927 KNKNSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSRPFNFAVYLTT 991
            |   :|..|..||   .:||.:..:.:. |::....|..:||:...||.: :.:||..|...||.
 Worm   972 K---TQEIEKVFN---FLGLEVSTRGNI-LNQHTLENWLLAEQDFEVSVE-NKNRPAEFTARLTV 1028

  Fly   992 -----------------ERKFTFKGIHTQ---EAFSQKWKLDYSTPGSK--------VSHDTTVV 1028
                             |::|..:..:|:   |.|::..|......|.|        ...|.|:.
 Worm  1029 GQLEKTELSQIKYNKIFEKEFELEQENTESRREYFNKMVKNIQKEQGYKSVISLKLEAPRDYTMN 1093

  Fly  1029 YELGN------------------------------------KPKTFSRLSFDNSQCHFAVEGGI- 1056
            .||..                                    :|:..|.|.....|.|..|:..:
 Worm  1094 TELTTVCDKQVRMCQWEVEIRRSPILEETKEWTLRSQLLVVRPEMPSSLRQLRDQPHREVQLSLT 1158

  Fly  1057 ----NNDKNELVVYGQYEQDKEIKKSKIGFSKNGN---EYKPLIEIQDNNGISNSINGYH--ADG 1112
                :..|:|:.|..|.:|.||.||.:....:..|   ||:.||:....|.| |::..|.  .:.
 Worm  1159 STWGSQKKSEVTVNAQLQQSKEQKKYERNMDRQFNGMPEYELLIKAARLNQI-NAVAEYKLTRET 1222

  Fly  1113 KIVVKKNSNNIERYNFENFQVS----NSNNAHVAVNGWSDVGTNSLT----SELRISLDHQTFLI 1169
            :.|:.:..:.::.||:  :.||    |:.|..|.|         .||    |...:::..|:.:.
 Worm  1223 EQVLARYFDLVKTYNY--WTVSSRPENNENDRVVV---------QLTVEPMSRQYVNITMQSPME 1276

  Fly  1170 KENLKLENGLYEAGFFINDEHSPENIYGSSIHL-TIADQSYALKTNGKAAAWSI----------G 1223
            :..||                   |:....::| :||.:|  :|.....|:.|:          .
 Worm  1277 RIELK-------------------NVQVPRVYLPSIAQRS--VKHQLTEASGSVCKVQKNQIRTF 1320

  Fly  1224 SDGSFN------FQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFDVNKMDVDVEISREQK 1282
            .|..:|      :..:|...|......|.:.:.: ||.:...||::.    .:.::..::..|:
 Worm  1321 DDVLYNTPLTTCYSLIAKDCSEEPTFAVLSKKTE-KNSEEMIIKVIR----GEQEIVAQLQNEE- 1379

  Fly  1283 IGSIIVKYESNQRHAQDYSLEASAKINKHSIDVI----SKCDFNGNVYVVDNSLVTSWGTLLSAK 1343
               |.||.:..:..::|||.....::.:.:| ||    .:..|:|  |.:...|.:
 Worm  1380 ---IRVKVDGKKIQSEDYSAYQIERLGESAI-VIELPEGEVRFDG--YTIKTQLPS--------- 1429

  Fly  1344 GEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTNSDFRISRDTSELIKLTSESQHP 1408
                  ||.::....:.||                  ..|::.::|           .||::...
 Worm  1430 ------YSRKNQLCGLCGN------------------NDDESTNEF-----------YTSDNTET 1459

  Fly  1409 QDKISFAKLNLIVKNQLTAKGEFRVAKNGKGDFTASIDTLKTEPKHKLEIESKFHIQSPK-YDID 1472
            :|...|.: :.::||:.....|.|:::.            |...|::.:.|......|.: ||.:
 Worm  1460 EDIEEFHR-SYLLKNEECEAEEERLSEK------------KNYRKYERDEEQSDEYSSEETYDYE 1511

  Fly  1473 ASLTLDG-KRKVHLKSENTIEKLK---------FSTKNIGE 1503
            ...|... |.:...|..:.:||.:         ||.:.:.|
 Worm  1512 QENTKKSQKNQRSQKKSDLVEKTQIKEFSHRICFSVEPVAE 1552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	136/642 (21%)
		DUF1943	605..911	CDD:286281	62/329 (19%)
		DUF1081	932..1031	CDD:283982	27/126 (21%)
		VWD	2789..2931	CDD:214566
vit-2	NP_508868.1	Vitellogenin_N	24..618	CDD:279663	139/651 (21%)
		DUF1943	653..944	CDD:286281	60/317 (19%)
		VWD	1299..1456	CDD:214566	34/212 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010