DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vit-4

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_508612.1	Gene:	vit-4 / 180646	WormBaseID:	WBGene00006928	Length:	1603	Species:	Caenorhabditis elegans

Alignment Length:	1755	Identity:	340/1755 - (19%)
Similarity:	653/1755 - (37%)	Gaps:	434/1755 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILASVLLTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDSDDTSLKVS 77
            |:.:.|:.:|:.|.       |..|.   .:.|.:.|.|.||.:|..|..:..   ||.:...:|
Worm     4 IIIASLVALAIAAS-------PALDR---TFSPKSEYVYKFDGLLLSGLPTTF---SDASQTLIS 55

  Fly    78 GSAKIFAKGNCGYTLQLSSVKVTNTK----------ESVEKKILNS-----IQKPVQFTLVSGIL 127
            ...::.|..:....|||..::.:.:.          ||:|::.|:.     ::.|.:..:.:|::
Worm    56 CRTRLQAVDDRYIHLQLIDIQYSASHIPQSEQWPKIESLEQRELSDELKELLELPFRAQIRNGLV 120

  Fly   128 EPQICSDSSDLDYSLNIKRAVVSLL--------------QSGIEAE--------HEVDVFGMCPT 170
            . :|...|.|.::|.|.||::::|.              |..:|::        ||..:.|.|..
Worm   121 S-EIQFSSEDAEWSKNAKRSILNLFSLRKSAPVDEMSQDQKDMESDKDSLFFNVHEKTMEGDCEV 184

  Fly   171 HTSTSKVGNANIITKARNLNSCSHREQINSGLVSG---KVNEKAGITSSLLLQANYIKESRIVNH 232
            ..:..:.|...|.||:.|.:.|..|.:...||..|   |..||.|         .:::...:..:
Worm   185 AYTIVQEGGKTIYTKSVNFDKCITRPETAYGLRFGSECKECEKEG---------QFVQPQTVYTY 240

  Fly   233 LIENVQLTE-------TYKFIGNTKRNSDISAKVVTI------LKLKNPSGTKANSPGTGSTVRS 284
            ..:|.:|.|       |....|.....|:..|||..:      .::|..||.|.....:... ..
Worm   241 TFKNEKLQESEVNSIYTLNVNGQEVVKSETRAKVTFVEESKINREIKKVSGPKEEIVYSMEN-EK 304

  Fly   285 LIFQRPETYTSKNINALKTILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAFPHPN 349
            ||.|..:......:|..|.|..:           :..::..|..|.:::.:..|       |...
Worm   305 LIEQFYKQGDKAEVNPFKAIEIE-----------QKVEQLEEIFRQIQEHEQNT-------PETV 351

  Fly   350 KVLARKVYLDGLFRTSTAESARVILKQL-SKFDEKEKLLAILSL----------NIVKSVDKETL 403
            .::||.|   .:||..|.|..:.:...: :|.::|.:|:...:|          :::...:|:::
Worm   352 HLIARAV---RMFRMCTIEELKKVHTTIYTKAEKKVQLVIETTLAVAGTKNTIQHLIHHFEKKSI 413

  Fly   404 NQ-AASQLLPNAPKELY-----------IAVGNLVAKY-CLKN---YCQGPEIDAISKKFSDGLK 452
            .. .|::||.:..:.||           :|...|..|| .|:.   ...|..:...:.|..| |.
Worm   414 TPLRAAELLKSVQETLYPSEHIADLLIQLAQSPLSEKYEPLRQSAWLAAGSVVRGFASKTQD-LP 477

  Fly   453 HCKPNTKREEERIVYI-----------------LKGLGNAK-SLSGNTVAALSECASTGRSNRIR 499
            ..:|.:::.:|:.|.:                 ||.||||. .||...:..|.:......|  ||
Worm   478 LIRPASRQTKEKYVRVFMQHFRNADSTYEKVLALKTLGNAGIDLSVYELVQLIQDPRQPLS--IR 540

  Fly   500 VAALHAFSKVK--CEETLQSKSLELLKNRNEDSELRIEAYLSAI-SCPNAEVANQISEIVNSETV 561
            ..|:.|...:|  ....:|...|.:.|||....|||:.|....: :.|...|...|...:.:|:.
Worm   541 TEAVDALRLLKDVMPRKIQKVLLPVYKNRQNKPELRMAALWRMMHTIPEEPVLAHIVSQMENESN 605

  Fly   562 NQVGGFISSNLKAIRDSTDVSRDQQKYHLANIRV-TKTFPVDYRRYSFNNEVSYKLESLGVGAST 625
            ..|..|..:.|:....||:....|.....:.:.: |:..|.:....:::....:..|.|. |...
Worm   606 QHVAAFTYNVLRQFSKSTNPCYQQLAVRCSKVLLFTRYQPQEQMLSTYSQLPLFNSEWLS-GVQF 669

  Fly   626 DYQIIYSQHGFLPRSSRINVTTEFFGTNYNVFEASV--RQENVEDVLEYYLGPKGLVNKDFDEIV 688
            |:..|:.::.|||:..:.:..| .||.|:|.:.|.|  .|:|.|.|:...|....|..|..||:
Worm   670 DFATIFEKNAFLPKEVQASFET-VFGGNWNKYFAQVGFSQQNFEQVILKTLEKLSLYGKQSDEL- 732

  Fly   689 KLIEVGNNGVAAGGRARR--SIVDDVSKISKKYKMY-GVKNVQDLNLDVSLKLFGSELAFLSLGD 750
                          |:||  |.:..:.:|.||..:. .|:.....|......|...|:.::.|..
Worm   733 --------------RSRRVQSGIQMLQEIVKKMNIRPRVQQTDSQNAHAVFYLRYKEMDYIVLPI 783

  Fly   751 NIPSSLDDIINYFSTSFEKAKQELSSF---EKQFSSHH--LFLDTDLAYPTSIGVPLELVAQGFA 810
            :: .::|:::..:..:.|...:.|.:|   :.:|..|.  .|.:.:...||:||:||.:
Worm   784 DM-ETIDNVVEKYVRNGEFDIKSLLTFLTNDSKFELHRALFFYEAERRIPTTIGMPLTI------ 841

  Fly   811 ATKVDLAVSLDINAILEQNWQKAKYRLKFVPSVDINANVQIGFNAQVLSTGLRVVSSA--HSATG 873
            :.|:...:|::....:|.....|:..|..||:|......::.|...|:..|::.:.||  |:...
Worm   842 SGKMPTILSINGKVSIELEKLGARLVLDIVPTVATTHVTEMRFWYPVIEQGVKSLQSARLHTPLR 906

  Fly   874 SDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGN-------KKNKNS 931
            .:.||             ||.:..||:      |..:|..::|:..:::...       .||::|
Worm   907 FESTV-------------ELKKNTLEI------THKFVVPENKKTTVSVHTRPVAFIRVPKNQDS 952

  Fly   932 QPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAER----GLSVSEKFHLSRPFNFAVYLTTE 992
            :..|             ..:.:.|.|:.|.....:..:    ||.::.:.::...:...:.|.||
Worm   953 EYVE-------------AEEKTISHSQYQMSTEEIDRQYETFGLRINAQGNVLSQWTLPMVLMTE 1004

  Fly   993 RKFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTF-SRLSFDNSQCHFAVEGGI 1056
            :.|.|                              ..|..|:|..| :|::..|.:
Worm  1005 QDFEF------------------------------TLENKNRPVEFTARVTIGNLE--------- 1030

  Fly  1057 NNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEY--KPLIEIQDNNGISNSIN---------GYHA 1110
            ..|.:|:.....:|::.:::.::   |:|..:|  |.:.|||...|..|.|.         .::.
Worm  1031 KTDLSEIKFDKIFEKEFDLENNE---SENRRQYFHKMIREIQSEQGFKNLITLKLEAPQQMYWNT 1092

  Fly  1111 DGKIVVKK-----------NSNNIERYNFE----------NFQVSNS---------NNAHVAVNG 1145
            :.:.|..|           ..:.||..|.|          ..|:.:|         ....:|:|.
Worm  1093 ELRTVCDKWIRMCKVEMDARRSPIEHENKEWTLRTELLAARPQMPSSLRQLREQPHREVQLALNA 1157

  Fly  1146 -WSDVGTNSLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSY 1209
             |.    :|..||:       ||    |.:||....:..|..|.|...:.|....:.:..|
Worm  1158 KWG----SSKKSEI-------TF----NAQLEQSTEQKKFLRNIEREYKGIPEYELLIKAA---- 1203

  Fly  1210 ALKTNGKAAAWSIGSDGSFNFQKLADSNSARAGSLVENVEIQYKNKQVG---GIKIMS----NFD 1267
            .|......:.:.:..:..:.|.::.|...|.....|....:|.::::|.   .::.:|    |..
Worm  1204 RLNQVNVVSEYKLTPESEYTFSRIFDLIKAYNFWTVSEKRVQNEDRRVVLQLSVEPLSRQYMNMT 1268

  Fly  1268 VNKMDVDVEISREQKIGSIIV--------------------KYESNQRHAQD-----------YS 1301
            :...:.:||: :..:|..:::                    |.:.::....|           ||
Worm  1269 IQTPEQEVEL-KNVRIPRVVLPTIARRAMFQQTWEKTGATCKVDQSEVSTFDNVIYRAPLTTCYS 1332

  Fly  1302 LEA------------SAKINKHSIDVISKCDFNGNVYVV----DNSLVTSWGTLLSAKGEIGQRY 1350
            |.|            :.||||:|.:::.|........||    |..||...|..::.. |: ::|
Worm  1333 LVAKDCSEQPRFAVLAKKINKNSEELLVKVVRREEEIVVKKSDDKFLVKVDGKKVNPT-EL-EQY 1395

  Fly  1351 SAQDININI------QGNVQISGKDKVTQW--------ILKVIGTPDKTNSDFRISRDTSE---- 1397
            :.:.:..|:      .|.|:..|....|..        :..:.|..|....:..::.|..|
Worm  1396 NIEILGDNLIVIRLPHGEVRFDGYTVKTNMPSVASQNQLCGLCGNNDGERDNEFMTADNYETEDV 1460

  Fly  1398 -------LIKLTSESQHPQDKISFAKLNLIVKNQLTAKGEFRVAKNGKGDFTASIDTLKTEPKHK 1455
                   |:| ..|.:..:|:||..|......|:...|.::    ....|:.::.|..:||.
Worm  1461 EEFHRSYLLK-NEECEVEKDRISEKKNYKNKWNREEKKSDY----ESSSDYESNYDEKETEK--- 1517

  Fly  1456 LEIESKFHIQSPKYDIDASLTLDGKRKVHLKSENTI-EKLKFS-----TKN----IGEANDKIIA 1510
             |:..|..|:.....:..|:....:.:..|:||.|. :|::|:     :||    :.||.::.:|
Worm  1518 -ELVKKTLIKEFSNRVCFSIEPVSECRRGLESEKTSNKKIRFTCMPRHSKNARRFLKEAREQTVA 1581

Fly 1511 1510
Worm 1582 1581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	130/630 (21%)
		DUF1943	605..911	CDD:286281	70/317 (22%)
		DUF1081	932..1031	CDD:283982	11/102 (11%)
		VWD	2789..2931	CDD:214566
vit-4	NP_508612.1	Vitellogenin_N	24..617	CDD:279663	130/630 (21%)
		DUF1943	651..942	CDD:286281	72/333 (22%)
		VWD	1300..1454	CDD:214566	27/155 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910