DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vit-6

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	NP_001023276.1	Gene:	vit-6 / 177619	WormBaseID:	WBGene00006930	Length:	1651	Species:	Caenorhabditis elegans

Alignment Length:	1909	Identity:	358/1909 - (18%)
Similarity:	676/1909 - (35%)	Gaps:	493/1909 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 MKYNIALIGILASVLLTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPND 68
            ||:.||| .:|.:.|.:..::..|:......:|     .:..|..|.|.|:..|:.|.  .||:.
Worm     1 MKFFIAL-ALLGAALASTHLDRYNSIERNIQES-----SFRAGREYRYLFNGQLSAGL--PVPST 57

  Fly    69 SDDTSLKVSGSAKIFAKGNCGYTLQLSSVK-VTNTKESVEKKIL----------------NSIQK 116
            ....|...|.....:..||. ..:||...: .|:.:||...|:|                ..:..
Worm    58 PQGISRLQSQVTLQWTDGNT-VRMQLQKTRFATSQQESNSMKMLPFERFEEVERMNREHQELLSM 121

  Fly   117 PVQFTLVSGILEPQICSDSSDLDYSLNIKRAVVSLLQSGI----------EAEHEVDVFGMCPTH 171
            ||:|....|::. :|....:|..:|.||||||:::||..|          :::::...|..  |:
Worm   122 PVEFDYEHGLVR-EIRFAENDQPWSENIKRAVINMLQVNILKKEKYEGAEKSDNQEPTFSF--TN 183

  Fly   172 TSTSKVGNANII--------------TKARNLNSCSHREQIN-----------SGLVSGKVNEK- 210
            ...:..|...::              .|:.|.:.|:.|..|:           ..|...|::..
Worm   184 VERTLEGECEVLYTVEEIKKEDEQRWAKSINFDKCTRRPYIHHVQTPVCKDCQQTLEQDKMSSTV 248

  Fly   211 -----AGITSSLLLQANYIKESRIVNHLIENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSG 270
                 .|.:||.|:.:..::...:...:.|..||...:..  ||........|...|.:::|...
Worm   249 LNYNITGTSSSFLINSVELRSQHLFAPISEKHQLVSAFTL--NTMELIYAGEKKTEIKQVRNEKT 311

  Fly   271 TK---------ANSPGTGSTVRSLIFQRPETYTSKNINALKTILSDLVD--STGDYVKKETAKKF 324
            ::         |......:.....:.|.|: :|...:..:|.:.|.:..  ..|: .:.|.|...
Worm   312 SELVYNQESEWAEQQWAQTGEEKYLRQLPQ-WTENKVEMIKKMFSLMAKQIEQGE-AELEAAHTV 374

  Fly   325 VEFIRLLRQSDSETLLEL--AAFPHPNKVLA---RKVYLDGLFRTSTAESARVILKQLSKFDEKE 384
            ...:::||:.:.|.|.::  ....|.::.:|   |.:|    |.|......||.::|.....:..
Worm   375 ARIVKVLRECNEEQLEQIYRHVAEHKDEKIAEQLRSIY----FNTLALAGTRVTIQQFVDKVQSR 435

  Fly   385 KLLAIL---------------SLNIVKSVDKETLNQAASQLLPNAPKELYIAVGNLVAKYCLKNY 434
            |.:|.|               ||.|.:.:.:...:..:|. .|...:..::..|.:|...|
Worm   436 KNIAPLKASVAIKTLVDMRYPSLAIAEDIARLCESDVSSS-FPALRQSCWLTYGAIVNGVC---- 495

  Fly   435 CQGPEIDAISKKFSDGLKHCKPNTKREEERIVYILKGLGNAKSLSGNTVAALSECASTG------ 493
            .|.|.: .:.|   :|:|.|..:.|   :|||..|.....:.|.....|.||...|:.|
Worm   496 GQTPRV-FVQK---NGVKMCPRDAK---QRIVDKLVQQFESASTRYEKVLALKTLANAGLDLSVY 553

  Fly   494 ----------RSNRIRVAALHAFSKVKCE--ETLQSKSLELLKNRNEDSELRIEAYLSAI-SCPN 545
                      ....||..|:.:|.:::.:  ..:|...:.:..||.:...:|:.|....| :.|.
Worm   554 PLEKIILNEQHETTIRTQAIESFRRLRTQMPTKIQRVLMPVYLNRQQPQHIRMSALHQIIYTQPE 618

  Fly   546 AEVANQISEIVNSETVNQVGGFISSNLKAIR------DSTDVSRDQQKYHLANIRVTKTFPVDYR 604
            ..|.:||...:..|...||..|..|.|::..      :.|..||.|..  |.||
Worm   619 WSVLSQIGNQLRQERNQQVRAFTLSLLRSYANNESPCEQTFSSRVQSL--LNNI----------- 670

  Fly   605 RYSFNNEVSYKLESLGVGASTDYQIIYS---QHGFLPRSSRINVTTEFFGTNYNVFEASVRQENV 666
              .|:::...:.||:....||     ||   |.||....:.:..|.....|.        ...::
Worm   671 --PFSSQEIDRFESVYGKWST-----YSRRHQSGFEANFASLFTTESVLPTE--------MMASI 720

  Fly   667 EDVL----EYYLGPKGLVNKDFDEIVK--LIEVGNNG----VAAGGRARRSI--VDDVSKISKKY 719
            |.||    ..|....|...|:.::|:|  |..|...|    |..|.||..|.  .:.:|.:.:|.
Worm   721 EGVLSGEWNQYFAQIGFTQKNMEKIIKKLLSNVQEKGLEQIVVRGKRASGSFQPTEFLSNLLEKL 785

  Fly   720 KM-YGVKNVQDLNLDVSLKLFGSELAFLSL-GDNIPSSLDDIINYFSTSFEKAKQELSSFEK--- 779
            :: ....:.||.:..|.::....:.|||.: .|:||..:..:|       :..:.|:...|:
Worm   786 RITRRQSSEQDPHAFVYIRHRDMDYAFLPIDADSIPEVVRSMI-------QGGRLEIGDIERVLA 843

  Fly   780 ---QFS-SHHLFL-DTDLAYPTSIGVPLELVAQGFAATKVDLAVSLDINAILEQNWQKAKYRLKF 839
               .|| |:..|| :|....||.:|:|::..::....:.:...|:.::.....:::...:.|::.
Worm   844 QGIHFSASNAAFLYETVRRVPTPMGLPVQFTSKMPTISSIRGQVTFELEPKNGKSFDGLRLRVQA 908

  Fly   840 VPSVDINANVQIGFNAQVLSTGLRVVSSAHSATGSDITVAVISDGEGFNVDLELPREKLELINFN 904
            .|.|         .:..|||  |||:..........:..||                    :|..
Worm   909 GPRV---------ASTHVLS--LRVICPIAEVGTKFLHQAV--------------------LNTP 942

  Fly   905 VDTELYVAEQDKQKAIALKGNKKNKNSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAER 969
            ||||:.:..:||....|:       .:.|||                                |:
Worm   943 VDTEIRMNWEDKVVIRAI-------YNTPSE--------------------------------EK 968

  Fly   970 GLSVSEKFHLSRPFNFAVYLTTERKFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNK 1034
            .:::.:    |||..|...:..:.:          .:.:..::.|..|..|         :|..
Worm   969 RIAMIQ----SRPVTFTRTVAPDAR----------QYPEPIEMTYMLPAHK---------QLSQ- 1009

  Fly  1035 PKTFSRLSFDNSQCHFAVEGGINNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNN 1099
                   |.|.......|:|.:|...:  |...|:..|..:   ::.:..|..:|:.:.|:
Worm  1010 -------SLDREYPQIRVQGTLNRPTS--VRIPQWIVDSNV---EVYYKPNVEQYEAIFEL---- 1058

  Fly  1100 GISNSINGYHADGKIVVKKNSNNIERYNFENFQVSNSNNAHVAVNGWSDVGTNSLTSELRI-SLD 1163
               |..|.|         |...|.|:       |...:|           |...|.:|... ..:
Worm  1059 ---NLYNNY---------KMEKNYEK-------VYKKHN-----------GRRYLEAEPEYDEEE 1093

  Fly  1164 HQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSYALKTNGKAAAWSIGSDGSF 1228
            |:..:.|:...|:|               |.:|.......|..:  .:|...:|..     :..|
Worm  1094 HREQITKKFEWLQN---------------EKVYQHVAKFEIKPE--VVKMEVEAVC-----NNDF 1136

  Fly  1229 NFQKLADSNSARAGSLVENVEIQY----------KNKQVGGIKIMS--NFDVNKMDVDVEISREQ 1281
            :|.|    ...|...|...::..|          |.::...:.:|.  |:..|.:.:::...:.|
Worm  1137 HFCK----TQIRGEELKATIQYVYPQTPRTVEELKEQKYRQLVVMGEMNYGENTIHININGQQSQ 1197

  Fly  1282 KIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVY------VVDNSLVTS--WGT 1338
            :....:.:.|....|  :..|||| :::::...|..:.:.....|      :|...|.|.  |.:
Worm  1198 EQKKFVKQIEQAPEH--ETLLEAS-RLDQYQTVVEYEFEPKPAQYFARYWNMVQAYLRTQYPWTS 1259

  Fly  1339 LLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTP------DKTNSDFRISRDTSE 1397
            .:..:.|..::      |: |:..:.:..:.::|  :...|.||      ::....||:  .|::
Worm  1260 RIETREEPSRK------NM-IRATINVEPRQRLT--VNMTIETPMETTVLERVELPFRL--PTAQ 1313

  Fly  1398 LIKLTSESQHPQ----DKISF---AKLNLIVKNQLTAKGEF-RVAKNGKGDFTASIDTL------ 1448
            :......|::.|    :||:.   .:.|.:||:  |....| :||.  :..||.....|
Worm  1314 IHYQPRNSRYEQKPVMEKIAHHASKQANCVVKS--TKINTFDQVAY--RNQFTPCYSVLAKDCGS 1374

  Fly  1449 -KTEPKHKLEIESKFHIQSPKYDIDASLTLDGKRKVHLKSENTIEKLKFSTKNIGEANDKIIAFE 1512
             |:||:..:.::.   |...|         :.|....:..||.||..|.....|...|.:.|.::
Worm  1375 EKSEPRFVVLMKK---INEKK---------EWKNVKVVYGENEIEMYKTEEGLICRVNGEEIEYQ 1427

  Fly  1513 ANGSLKGE------LRGNGEIQGTFIFNAPDGRVIDGSINRKIS-----TNAKSGLSQGNIDAQL 1566
            ....::.:      |..|     |..|::.|..|....:|.:|.     .|.:.||. |:.|.:
Worm  1428 PESEIEKKQYNIIWLNKN-----TLKFDSDDVTVQFDGVNARIHLSALYRNQQCGLC-GHYDNE- 1485

  Fly  1567 SDTPF--GSNKKRSI-----SLIGKLDRLNTKTKEFSANSNLVYTAFNGEK---SEISYQIKQQP 1621
            .:|.|  ..|::.:|     |.:.|..:.|.:.:.|....|......|.|:   .|::|:..::.
Worm  1486 KETEFYDAENQENTIPKFAKSYLYKDSKCNYEREMFEKEENFQRIEKNQEEEKDQEMNYEESRRE 1550

  Fly  1622 NGDAKNIDFSLKAYGNPLPQPFEIAFALGDYSAQHAVV---------SITSKYGEIFSVSANGNY 1677
            ..|......::      :.:..||.|      .|..|:         |...|...::.:.::.::
Worm  1551 QDDEPTEQVAI------VERQHEICF------TQKPVLRCQNGKSQESKKQKVTSVYCLPSSNSW 1603

  Fly  1678 NNNQALEYGLQANIEIPKSTLKSL 1701
            ...|..|...:...:.|:..|::|
Worm  1604 ARRQMREIRREPLAQWPEHKLRNL 1627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	126/637 (20%)
		DUF1943	605..911	CDD:286281	69/330 (21%)
		DUF1081	932..1031	CDD:283982	11/98 (11%)
		VWD	2789..2931	CDD:214566
vit-6	NP_001023276.1	Vitellogenin_N	34..646	CDD:279663	126/637 (20%)
		DUF1943	679..979	CDD:286281	78/393 (20%)
		VWD	1339..1495	CDD:214566	39/178 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I7810
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14439
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010