DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and Ccnf

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	XP_038941012.1	Gene:	Ccnf / 117524	RGDID:	67401	Length:	818	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	153/774 - (19%)
Similarity:	253/774 - (32%)	Gaps:	256/774 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1124 ERYNFE-----------NFQVSNSNNAHVAVNG----------------------------WSDV 1149
            |:.|||           |..:|.|:.|...|||                            ||..
  Rat   134 EKGNFEAAVKLGIAYLYNEGLSVSDEACAEVNGLKASRFFSMAERLNTGSDPFIWLFIRPPWSVS 198

  Fly  1150 GT-------NSLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEH---SPENIYGSSIHLTI 1204
            |:       :||.:|.::...|:..::....::.| |:|      ||.   ...|::..|.|...
  Rat   199 GSCCKAVVHDSLRAECQLQRSHKASILHCLGRVLN-LFE------DEEKRKQAHNLFEESAHQGC 256

  Fly  1205 ADQSYALKTNGKAAAWSIGSDGSFNFQKLAD-------------SNSARAGSLV--------ENV 1248
            ...||.|..:.:....|.......:|:||.|             :.:...||.:        |:|
  Rat   257 LASSYLLWESDRKVDMSDPGRCLHSFRKLRDYAAKGCWEAQLALAKACAGGSQLGLEGKACSESV 321

  Fly  1249 -----EIQYKNKQVGGIKIMSNFDVNK----------MDVDVEISREQKIGSI--------IVKY 1290
                 ..|..|||       ..|.|.|          :|..||::..:...|:        :.:|
  Rat   322 CQLFQASQAVNKQ-------QIFSVQKGLSDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRY 379

  Fly  1291 ESNQRHAQDYSLE---------ASAKINKHSIDVISKCDFNGNVYVVDNSLVTSWGTLLSAKGEI 1346
             ..:|....|.|:         .:..|:|..:.:........|.|..:: ||...|.::||
  Rat   380 -LRRRLVPRYKLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYED-LVRVMGEIISA---- 438

  Fly  1347 GQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTNSDFRISRDTSELIKL-TSESQHPQD 1410
                        ::|.::|.......:.:|.::....:|.   .:.....||..| ||.|.:...
  Rat   439 ------------LEGKIRIPTVVDYKEVLLTLVPVAPRTQ---HLCSFLCELTLLHTSLSVYAPA 488

  Fly  1411 KISFAKLNLIVK----------NQLTAKGEFRVAKNGKGDFTASIDTLKTEPKHKLEIESKFHIQ 1465
            :::.|.| |:.:          .||.....|..:     |.|..:.:|     ||    ..||..
  Rat   489 RLASAAL-LLARLMHGHTQPWTTQLWDLTGFSYS-----DLTPCVLSL-----HK----KCFHDD 538

  Fly  1466 SPKYDIDASLTLDGKRKVHLKSENTIEKLKFSTKNIGE-ANDKIIAFEANGSLKG---------E 1520
            :||          ..|:|.|    |..|.:|..|...| :.::::::....|..|         .
  Rat   539 APK----------DYRQVSL----TAVKQRFEDKCYEEISQEEVLSYAELCSALGVKQESPEPPS 589

  Fly  1521 LRGNGEIQGTFIFNAPDGRVIDGSINRKISTNAKSGLSQGNIDAQLS---DTPFGSNKKRSISLI 1582
            ...:|||. ||: ::|.||  .....|:.|.....|.......|:||   :|..||....|:...
  Rat   590 FPSSGEIH-TFL-SSPSGR--RSKRKRENSLQEDRGSFVTTPTAELSNQEETLLGSLLDWSLDCC 650

  Fly  1583 ----GKLDRLNTKTKEFSANSNL-----VYTAFNGEK--------SEISYQIKQQPNGDAKNIDF 1630
                |..:....|..:.:|.|.|     ||  .|.|:        .|:..:.|..|....:
  Rat   651 SGYEGDQESEGEKEGDVTAPSGLLDVTVVY--LNPEEHCCQESSDEEVWPEDKSHPTPGTQ---- 709

  Fly  1631 SLKAYGNPLPQPFEIAFALGDYSAQHAVVSITSKYGEIFSVSANGNYNNNQALEYGLQANIEIPK 1695
                 ..|...|:.:....||....    ..||.|..:.|.|.      ..:|:.|:   :..|:
  Rat   710 -----APPASAPWPLPCNRGDPGKD----VTTSGYSSVSSSSP------ISSLDGGM---VGSPR 756

  Fly  1696 STLKSLEINSHG-------KVLKSLI------GNENAAY-------NVEFFLDSKTSLG 1734
            || ..|.:.||.       :..||.:      ..|:.|:       |:....|..|:||
  Rat   757 ST-SVLSVGSHSSTKPCYHQAKKSCLQCRPPNPPESGAHQQPVKRQNLSVHSDEDTNLG 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663
		DUF1943	605..911	CDD:286281
		DUF1081	932..1031	CDD:283982
		VWD	2789..2931	CDD:214566
Ccnf	XP_038941012.1	FBOX	73..111	CDD:197608
		CYCLIN_CCNF_rpt1	345..439	CDD:410225	17/111 (15%)
		CYCLIN_CCNF_rpt2	467..578	CDD:410226	30/139 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9078
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000