DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and vtga2

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	XP_002931744.3	Gene:	vtga2 / 100485207	XenbaseID:	XB-GENE-5791429	Length:	1802	Species:	Xenopus tropicalis

Alignment Length:	1993	Identity:	365/1993 - (18%)
Similarity:	671/1993 - (33%)	Gaps:	580/1993 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GILASVLLTIA---------VNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPN 67
            ||:.::||.:|         |.:|:..::                   |::::::..|    .|.
Frog     3 GIILALLLALAGSERTHIEPVFSESKASV-------------------YNYEAVILNG----FPE 44

  Fly    68 DS-DDTSLKVSGSAKIFAKGNCGYTLQLSSVKVTN----------TKES-VEKKILNSIQKPVQF 120
            .. ....:|::...:|.|.....|.:::.|.::..          |:.| :.:.:.:.:.||.:|
Frog    45 SGLSRAGIKINCKVEISAFAQRSYFIKIQSPEIKEYNGVWPKDPFTRSSKLTQALADQLTKPARF 109

  Fly   121 TL----VSGILEPQICSDSSDLDYSLNIKRAVVSLLQSGIEAEHEV------DVFGMCPTH--TS 173
            ..    |..|..|...||:     ::||.|.:::|||..::....|      .|.|:|.|.  ..
Frog   110 EYSYGRVGDIFVPDDVSDT-----AVNIYRGILNLLQLTLKKSQNVYDLQESSVGGICHTRYVIQ 169

  Fly   174 TSKVGNANIITKARNLNSCSHR----------------EQINSGLVSGKVNEKAGITSSLLLQAN 222
            ..:.|:...|.||.:.|:|..:                :|:|..|       :...|.:..|:|
Frog   170 EDRRGDRINIIKATDFNNCQEKVSKSFGFELSDFCHSCKQMNRNL-------RGAATYTYKLKA- 226

  Fly   223 YIKESRIVNHLIENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVR-SLI 286
                 |....:|..|...:..:|....:||...:.:...:|........:.|.|......| :|.
Frog   227 -----RDQGTVIMEVTARQVIQFTPFNERNGAATMEARQVLAWVGSKSGQMNPPQIQLKNRGNLH 286

  Fly   287 FQRPETYTSKNINALKT---------ILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLEL 342
            :|.........|:.:||         :|..|:..|...::::...||::.|:|||.||.|.:..|
Frog   287 YQFASESHQMPIHLIKTKSPEAQAVEVLQHLIQDTQQQIREDAPAKFLQLIQLLRASDFENIQAL 351

  Fly   343 AAFPHPNKVLARKVYLDGLFRTSTAESARVILKQLSKFDE--KEKLLAILSLNIVKSVDKETLNQ 405
            .. ....:...|:..|:.:....|.:..::| |||...:|  .::...|::..:..:...:...|
Frog   352 WK-QFAQRTQYRRWLLNAIPMAGTVDCLKLI-KQLIHNEELTPQEAAVIVTFAMRSARPSQRAFQ 414

  Fly   406 AASQLLPNAPKELYIAVGNLVAKYCLKNYCQGPEIDAISKKFSDGLKHCKPN------------- 457
            .::..:.::..:.|    ::|.|..|.:|      ..:.||:.|.|..| ||
Frog   415 FSADFVQDSKVQKY----DVVYKAALLSY------GTMVKKYCDQLSSC-PNQALEPLHELAAEA 468

  Fly   458 -TKREEERIVYILKGLGNA----------KSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKC 511
             .|...|.|...||.||||          |.|...|.:|..      ...||:..|:.|...:..
Frog   469 ANKGHAEDIALALKALGNAGQPESIKQIQKFLPAITSSAYQ------LPVRIQTDAVMALRNIAK 527

  Fly   512 EE--TLQSKSLELLKNRNEDSELRIEAYLSAISC-PNAEVANQISEIV--NSETVNQVGGFISSN 571
            :|  .:|...|::..:|:..:|:|:.|.|:.... |.......|:.:.  .|:|..|:..|..|.
Frog   528 QEPRKVQEILLQIFMDRDARTEVRMMACLALFETKPGLATVTAIANVAARESKTNLQLASFTYSQ 592

  Fly   572 LKAIRDS------------------TDVSRDQQKYHLANIRVTKTFPVDYRRYSFNNEVSYKLES 618
            :||:..|                  .:.|.|...|     |.:|...||..:|           :
Frog   593 MKALAKSRVAQLEPLAAACGVALKILNPSLDNLGY-----RYSKVMRVDTFKY-----------N 641

  Fly   619 LGVGASTDYQIIYSQHGFLPRSSRINVTTEFFGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKD 683
            |..|.:..:.::.|.:...|         .|.......:.::|..:|:|      :|.:|   :.
Frog   642 LMAGVAAKFYVMNSANTMFP---------VFILAKLREYTSAVESDNIE------IGIRG---EG 688

  Fly   684 FDEIVKLIEVGNNGVAAGGRARRSIVDDVSKISKKYK-MYGVKNV--QDLNLDVSLKLFGSELAF 745
            .:|.::    ..|...|....|:       |||:..| :.|.|.:  |...|...:||.|.|:||
Frog   689 IEEFLR----KQNTQFADFPMRK-------KISQLVKTLLGFKGLPSQVPLLSGYVKLEGQEIAF 742

  Fly   746 LSLGDNIPSSLDDIINYFSTSFEKAKQE----------LSSFEKQFSSHHLFLDTDLAYPTSIGV 800
            ..|...:      |.|.|....|.|::.          |:....|::...:..:.....||::|:
Frog   743 SQLNKEV------IQNIFRALNEPAERHTMIRNVLNKLLNGVVGQYAQAWMSWEYRHIIPTTVGL 801

  Fly   801 PLELVAQGFAATKVDLAVSLDINA------------ILEQNWQKAKYRLKFVPSVDINANVQIGF 853
            |.|:..  :.:..|:..|:.|:..            :||...| ...::|  ||:.::....||.
Frog   802 PAEISL--YQSAIVNAGVNSDMKVKPNPSGDFSAAQLLESQIQ-LNGQVK--PSIRVDTVATIGI 861

  Fly   854 NAQVLSTGLRVVSSAHSATGSDITVAVISDGEGFNVDLELPREKLELINFNVDTELY---VAEQD 915
            |:::|..|:......|:...:..|..:......|.::....:::..|:.|...|..:   :|:.|
Frog   862 NSRLLQAGIEFHGKMHAHLPAKFTAYLDMKERNFKIETPPCQQEDHLVQFRAQTFAFTRNIADLD 926

  Fly   916 -KQKAIALKGNKKNKNSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHL 979
             .:|.:.:..|.:      ..|.....|..|     ::|...:.:...:..:..|..|.....|.
Frog   927 AARKTLVVPRNSE------QNILKKHFESTG-----RASAEGASMMEDSSEMGPRKYSTEPGPHQ 980

  Fly   980 SRPFNFAVYLTTERKFTFKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFSRLSFD 1044
            :.|.|...| ....||:..|::    |..:.|..     :..:|..|.:|:...:    ....|.
Frog   981 NAPANVNSY-DACTKFSKAGVN----FCIQCKTH-----NAAAHRNTFLYQAVGE----HEFKFT 1031

  Fly  1045 NSQCHFAVEGGINNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNN---------- 1099
            ....|  .||.|...:.|:....|       ..|||         |.|:|::|..
Frog  1032 MKPAH--SEGAIEKLQLEITAGPQ-------AASKI---------KGLVEVKDTEDEQMDDSAVQ 1078

  Fly  1100 -------GISNSINGYHADGKIVVKKNSNNIERYNFENFQV-----------SNSNNAHVAVNGW 1146
                   ||.:||...:....:..|::..|.:.....:.:|           |:|:::..:.:..
Frog  1079 KRLKMILGIDDSIKDTNGTAVLRSKQSRKNKKHKRPLDAEVVAEAKKPQSSSSSSSSSSSSSSSS 1143

  Fly  1147 SDVGTNSLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSYAL 1211
            |...::|.:|....|....::..:...:              ||.|......|   :.:.|....
Frog  1144 SSSSSSSSSSSSSSSSSSSSYSQRSRRR--------------EHHPHQQRQPS---SSSSQEKDK 1191

  Fly  1212 KTN-------GKAAAWSIGSDGSFNFQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFDVN 1269
            |.|       |:.|..|..|..|.:....:.|:|:.:.|...|...:::|:|....:.....:.|
Frog  1192 KNNWQENRKHGQKAQSSSSSSSSSSSSSSSSSSSSSSSSSSSNENRRHRNRQHDNEQAKKQHEQN 1256

  Fly  1270 KMDVDVEISREQKIGSIIVKYESNQRHAQDY--------------------------SLEASAKI 1308
            |.    ..|......|.....|..::|.:::                          |...||..
Frog  1257 KN----RYSSSSSSSSSSSSSEMQKKHHRNFYDLHFRRAARTKDTEKRASSSSESSSSSSESAYA 1317

  Fly  1309 NKHS-----------IDVISKCDFNGN---------------------VYVVDNSLVTSWGTLL- 1340
            |:|.           :.|..|...|.|                     .||:|.| .|.|...|
Frog  1318 NRHKAKFLGDKQPPVLVVTFKAVRNDNTKQGYQMVVYQDYHSSKQQIQAYVMDIS-KTRWAACLD 1381

  Fly  1341 -------SAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGT----PDKTNS------- 1387
                   .|:..:....:.||..||.:......|    .|..|||...    |.|..|
Frog  1382 AVVVNPHEAQASLKWGQNCQDYKINFKAETGNFG----NQPALKVTANWPKIPSKWKSTGKAVAH 1442

  Fly  1388 -------------DFRISRDTSELIKLT-------------------------------SESQHP 1408
                         ::|  |::...:||.                               ....|.
Frog  1443 YVPGGMYMLGFQGEYR--RNSQRQVKLVFALSSPRTCDVVIQMPRLTVYYRTMRLPVPIPVGHHA 1505

  Fly  1409 QDKI-------SFAKLNLIVKNQLTAKGEFRVAK------NG---------------------KG 1439
            ::.:       .||:...||.:.:  :||.:|.:      ||                     :.
Frog  1506 KENVLQTPTWNIFAEAPQIVMDSI--QGECKVGQDQITTFNGIDLASALPENCYHVLAQDCSHEL 1568

  Fly  1440 DFTASIDTLKTEPKHKLEIESKFHIQSPKYDIDASLTLDG-KRKVHLKSENTIEKLKFSTKNIGE 1503
            .|...:...|..|.||     .|:::...||||...:.|. |.|:: ..|.:.|:|.:.:.:...
Frog  1569 KFMVLMRNSKESPNHK-----AFNVKLGAYDIDMYYSADSLKMKIN-GIELSEERLPYKSFDYPT 1627

  Fly  1504 ANDKIIAFEANGSL--------------------------KGE---LRGNGEIQGTFIFNAPDGR 1539
            ..   |..|.||.|                          ||:   :.|:.:.:....|..|||
Frog  1628 VE---IKKEGNGVLLSAPEYGIDFINYDGLTLKMRPALWMKGKTCGICGHNDDESEKEFQMPDG- 1688

  Fly  1540 VIDGSINRKISTNAKSGLSQGNIDAQLSDTPFGSNKKRSISLIGK-LDRLNTKTKEFSANSNL-- 1601
                    .::.:..|.:....:.|:....  |.:.:||:..:.| ::....|.|.:|....|
Frog  1689 --------SMAKDTMSFIHSWILPAESCSE--GCHVQRSLVKLEKPIETDGAKAKCYSVQPVLRC 1743

  Fly  1602 -----------VYTAFNGEKSEISYQIKQQPNGDAKNIDFSLK 1633
                       |.|.|:...|::|..:.:......|:.||:.|
Frog  1744 AKGCSPVKTVEVATGFHCLPSDVSLDLPEAQTRLEKSEDFTDK 1786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	123/610 (20%)
		DUF1943	605..911	CDD:286281	62/333 (19%)
		DUF1081	932..1031	CDD:283982	18/98 (18%)
		VWD	2789..2931	CDD:214566
vtga2	XP_002931744.3	Vitellogenin_N	24..594	CDD:396081	124/629 (20%)
		DUF1943	628..911	CDD:401204	64/333 (19%)
		DUF1944	1331..1496	CDD:401207	28/171 (16%)
		VWD	1525..1688	CDD:214566	32/173 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23345
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100