DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment apolpp and XB5965023

DIOPT Version :9

Sequence 1:	NP_001259085.1	Gene:	apolpp / 43827	FlyBaseID:	FBgn0087002	Length:	3351	Species:	Drosophila melanogaster
Sequence 2:	XP_002931743.3	Gene:	XB5965023 / 100485054	XenbaseID:	XB-GENE-5965024	Length:	1818	Species:	Xenopus tropicalis

Alignment Length:	2059	Identity:	382/2059 - (18%)
Similarity:	715/2059 - (34%)	Gaps:	564/2059 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GILASVLLTIAVNAENACNLGCPKSDNGLLKYIPGNYYDYSFDSILTIGASSDVPNDS-DDTSLK 75
            ||:.::||.:|.:..........:|...:          |::::::..|    .|... ....:|
Frog     3 GIILALLLALACSERTQIEPVFSESKTSV----------YNYEAVILNG----FPESGLSRAGIK 53

  Fly    76 VSGSAKIFAKGNCGYTLQLSSVKVTN----------TKES-VEKKILNSIQKPVQFTLVSG---- 125
            ::...:|.|.....|.:::.|.::..          |:.| :.:.:.:.:.||.:|...:|
Frog    54 INCKVEISAFAQRSYFIKIQSPEIKEYNGVWPKDPFTRSSKLTQALADQLTKPAKFVYSNGRVGD 118

  Fly   126 ILEPQICSDSSDLDYSLNIKRAVVSLLQSGIEAEHEV------DVFGMCPTH--TSTSKVGNANI 182
            |..|...||:     .:||.|.:::|.|..|:....|      .|.|:|.|.  ....:.|:...
Frog   119 IFVPDDVSDT-----VVNIYRGIINLFQLTIKKSQNVYDLQESSVGGICHTRYVLQEDRRGDRIN 178

  Fly   183 ITKARNLNSCSHREQINSGL-------------VSGKVNEKAGITSSLLLQANYIKESRIVNHLI 234
            |.||.:.::|  :|:::.|:             :...::..|..|        |..::|....:|
Frog   179 IIKATDFSNC--QEKVSKGIGFDLTESCASCKQIHRNIHGAATYT--------YKLKARDQGTVI 233

  Fly   235 ENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSGTKANSPGTGSTVR-SLIFQRPETYTSKNI 298
            ..|...:..:|....:||...:.:...||..........|.|......| :|.:|.........|
Frog   234 MEVTSRQVIQFTPFAERNGAGTMEARQILVWIGSKSGHMNPPQIQLKNRGNLHYQFASELHQMPI 298

  Fly   299 NALKT---------ILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDSETLLELAAFPHPNKVLAR 354
            :.:||         :|..|:..|...::::...||::.|:|||.||.|.:..|.. ....:...|
Frog   299 HLMKTKSPEAQAVEVLQHLIQDTQQQIREDAPAKFLQLIQLLRASDFENIQALWK-QFAQRTQYR 362

  Fly   355 KVYLDGLFRTSTAESARVILKQLSKFDEKEKLLAILSLNIVKSVDKETLNQAASQLLPNAPKELY 419
            :..||.:....|.:..::| |||...:|.....|  ::.|..::.....:|.|.||..:..::..
Frog   363 RWLLDAIPMAGTVDCLKLI-KQLIHNEELSPQEA--AVTITFAMRSARPSQQALQLSADFVQDSK 424

  Fly   420 IAVGNLVAKYCLKNYCQGPEIDAISKKFSDGLKHCKPN-------------TKREEERIVYILKG 471
            :...|.|.|..:..|      ..:.||:.|.|..|..:             .|...|.|...||.
Frog   425 VQKYNTVHKAAILAY------GTMVKKYCDQLSSCPEHALEPLHELAAEAANKGHAEIIALALKA 483

  Fly   472 LGNA----------KSLSGNTVAALSECASTGRSNRIRVAALHAFSKVKCEETLQSKS--LELLK 524
            ||||          |.|...|.:|..  ...|    |:..|:.|...:..:|..:.:.  |::..
Frog   484 LGNAGQPESIKQIQKFLPAITSSAYQ--LPVG----IQTDAVMALRNIAKQEPRKVREILLQIFM 542

  Fly   525 NRNEDSELRIEAYLSAISC-PNAEVANQISEIV--NSETVNQVGGFISSNLKAIRDST------- 579
            :|:..:|:|:.|.|:.... |.......|:.:.  .|:|..|:..|..|.:||:..|:
Frog   543 DRDARTEVRMMACLALFETKPGLATVTTIANVAARESKTNLQLASFTYSQMKALAKSSVAQLKPL 607

  Fly   580 -----------DVSRDQQKYHLANIRVTKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQ 633
                       :.|.|...|     |.:|...||          ::|...:..||...| |:.|.
Frog   608 AAACTVALKILNPSLDNLGY-----RYSKVMRVD----------TFKYNLMAGGAGKVY-IMNSA 656

  Fly   634 HGFLPRSSRINVTTEF----FGTNYNVFEASVRQENVEDVL-----EYYLGPKGLVNKDFDEIVK 689
            :...|    :.:..:|    .|...::.|..:|.|.:|:.|     ::...|   ::|...:|||
Frog   657 NTMFP----VFILAKFREYLAGIESDILEIGIRGEGIEEFLRKQNTQFADFP---MHKKISQIVK 714

  Fly   690 LIEVGNNGVAAGGRARRSIVDDVSKISKKYKMYGVKNVQDLNLDVSLKLFGSELAFLSLGDNIPS 754
            .: :|..|:.                |:|..:.|.           :||.|.|:||.::...:
Frog   715 TM-LGFKGLP----------------SQKPLLSGY-----------VKLLGQEIAFTNINKEV-- 749

  Fly   755 SLDDIINYFSTSFEK-------AKQELSSFEKQFSSHHLFLDTDLAYPTSIGVPLELVAQGFAAT 812
             :.:||...:...|:       ..:.|.....|::...:..:.....||::|:|.|...  :.:.
Frog   750 -IQNIIRALNEPAERHTMIRNLLNKLLGGVVGQYAKAWMTGEYRYIIPTTVGLPAEFSL--YHSA 811

  Fly   813 KVDLAVSLDINAILEQNWQKAKYRLKFVPS------------VDINANVQ----------IGFNA 855
            .|:.||:.||             ::|..||            |.:||:|:          :|.|:
Frog   812 IVNAAVNSDI-------------KVKPNPSEDFSVAQLLESQVQLNADVKPSLMFYKVGTMGINS 863

  Fly   856 QVLSTGLRVVSSAHSATGSDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAI 920
            ::|..|:......|:...:..|..:......|.::....:::..|:.....|  :|..::.:.
Frog   864 RLLQAGIEFHGKVHAHLPAKFTAYLDMKERNFKIETPPCQQENHLVELRAQT--FVVTRNIED-- 924

  Fly   921 ALKGNKKN----KNSQPSEICFNQLELVGLNICIKSSTSLSEVQAGNGNVAERGLSVSEKFHLSR 981
             |...|||    :||:|: |.....:..|     :||...:.:...:..:|.|..|.....|.:.
Frog   925 -LDAAKKNLVVPRNSEPN-ILKKHFDSTG-----RSSAEGASMIEVSSEMAPRKYSREPGQHQNA 982

  Fly   982 PFNFAVYLTTERKFTFKGIH------TQEAFSQKWKLDYSTPGS-------KVSHDTTVV----Y 1029
            |.|...| ....||:..|::      |..|.:.:....|...|.       |.:....|:    .
Frog   983 PANVNSY-DACTKFSKAGVNFCIQCKTHNAAAHRNTFLYQAIGEHEFKLTMKPARTDRVIEKLQL 1046

  Fly  1030 ELGNKPKTFSRLSFDNSQCHFAVEGGINNDKNELVVYGQYEQDKEIKKSKIGFSKNGNEYKPLIE 1094
            |:...||..|:|.           |.:..:..:    |:...|..::|          ..|.::.
Frog  1047 EIATGPKAASKLM-----------GLVEVEDTK----GEQLDDVAVQK----------RLKLILG 1086

  Fly  1095 IQD---NNGIS-----------NSINGYHADGKIVVKKNSNNIERYNFENFQVSNSNNAHVAVNG 1145
            |.|   |..::           :.::....|.::|..:..        ::...|:|:::..:.:.
Frog  1087 IDDSAKNTNVTAILRSRPSKKEHKVHNRTLDAEVVQARKQ--------QSSSSSSSSSSSSSPSS 1143

  Fly  1146 WSDVGTNSLTSELRISLDHQTFLIKENLKLENGLYEAGFFINDEHSPENIYGSSIHLTIADQSYA 1210
            .|...::|.:|....|....::..:.|.:......:      :|.|..:......:....|::..
Frog  1144 SSSSSSSSSSSSSSSSSSSSSYSQRSNRRRHQNQQQ------EESSSSSSQEQDKNKNRQDKNKN 1202

  Fly  1211 LKTNGK--AAAWSIGSDGSFNFQKLADSNSARAGSLVENVEIQYKNKQVGGIKIMSNFDVNKMDV 1273
            .:.|.|  ..|||..|..| :....:.|:|:.:.|...:....||.:|            ::.|.
Frog  1203 RQENRKHGQKAWSSSSSRS-SSSSSSSSSSSSSSSSESSPSRSYKERQ------------HENDQ 1254

  Fly  1274 DVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVYVVDNSLVTSWGT 1338
            ..:.||:.:        ::..:::...|..:|:..:..|.::.||...:.|.|
Frog  1255 RKKQSRQNQ--------QNKNKYSSSSSSSSSSSSSSSSSEMWSKKKHHRNFY------------ 1299

  Fly  1339 LLSAKGEIGQRYSAQDININIQGNVQISGKDKVTQWILKVIGTPDKTNSDFRISRDTSELIKLTS 1403
                  ::..|.:|:..|...||:...|..:..:.....|.....||              |...
Frog  1300 ------DLHFRRAARTQNTKQQGSQSSSSSESSSSSSQSVSANRHKT--------------KFLG 1344

  Fly  1404 ESQHPQDKISFAKLNLIVKNQLTAKGEFRVAKNGKGDFTAS--------IDTLKTEPKHKLEIES 1460
            :.|.|....:|.    .|.|..|.:|...|...   |:.:|        :|..||.....|:.
Frog  1345 DKQSPVFVATFR----AVLNDNTKQGYQMVLYQ---DYHSSKQQIQAYVMDISKTRWAACLDA-- 1400

  Fly  1461 KFHIQSPKYDIDASLTLDGKR----KVHLKSEN-------------TIEKLKFSTKNIGEANDKI 1508
               :.:.:||..|||.. |:.    |::.|::.             .:.|:....|:.|    |.
Frog  1401 ---VVNNQYDAQASLKW-GQNCQDYKINFKAQTGHFGNQPALKLTADLPKIPSKWKSTG----KY 1457

  Fly  1509 IAFEANGSL-----KGELRGNGEIQGTFIFNAPDGRVIDGSINRKISTNAKSGLSQGNIDAQLSD 1568
            :|....|.:     :||.|.|.:.|...:|.....|..|..:.....|.....|.     ..||
Frog  1458 VADYVPGGMYMLGFQGEYRRNSQRQVKLVFALSSPRTCDIVMQMPRFTVYYRALR-----LPLS- 1516

  Fly  1569 TPFGSNKKRSI------SLIGKLDR--LNTKTKEFSANSNLVYTAFNGEK--------------- 1610
            .|.|.:.|.|:      ::..:..:  :|:...|.....|.: |.|||.:
Frog  1517 IPVGHHAKESVLQTPTWNIFAEAPQIIMNSLQGECKVAQNQI-TTFNGIEFASVLPENCYHVLAQ 1580

  Fly  1611 ---SEISYQI-----KQQPNGDAKNIDFSLKAYGNPLPQPFEIAFALGDYSAQHAVVSITSKYGE 1667
               .|:.:.|     |:.||..|.|:  .|.||               |....::..|:..|
Frog  1581 DCSHELKFMILMRNSKESPNHKAINV--KLGAY---------------DIDMNYSPKSLKMK--- 1625

  Fly  1668 IFSVSANGNYNNNQALEYGLQANIEIPKSTL-------KSLEINSHGKVLKSLIGNENAAYNVEF 1725
                 .||               ||:|:..|       .::||...|..: |:...|   |.:|
Frog  1626 -----ING---------------IEVPEERLPYKSFADPTVEIKKKGDGV-SISAPE---YGIE- 1665

  Fly  1726 FLDSKTSLGQYARVNTVWNGTANDGSYDFEAQTNNMESPLKFNGKY---------HRKQTGNIKD 1781
                                     |.||:..|..|.:.|...||.         ..::...:.|
Frog  1666 -------------------------SLDFDGLTFKMRAALWMKGKTCGICGHNDDESEKEFQMPD 1705

  Fly  1782 GDLTGKQT------YVLNAQYGAQYVKMDASLGYGAEKVDIAYV 1819
            |.: .|.|      ::|.|:..::...:..||....:::|.|.|
Frog  1706 GSM-AKDTMSFIHSWILPAESCSEACNLQRSLVQLEKEIDEANV 1748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	123/604 (20%)
		DUF1943	605..911	CDD:286281	61/343 (18%)
		DUF1081	932..1031	CDD:283982	21/115 (18%)
		VWD	2789..2931	CDD:214566
XB5965023	XP_002931743.3	Vitellogenin_N	24..594	CDD:396081	124/614 (20%)
		DUF1943	628..909	CDD:401204	63/344 (18%)
		DUF1944	1349..1514	CDD:401207	37/186 (20%)
		VWD	1548..1706	CDD:214566	40/228 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000