Protein Alignment apolpp and apobb.2

DIOPT Version :9

• Sequence 1: NP_001259085.1
• Gene: apolpp / 43827
• FlyBaseID: FBgn0087002
• Length: 3351
• Species: Drosophila melanogaster
• Sequence 2: XP_002665852.3
• Gene: apobb.2 / 100330435
• ZFINID: ZDB-GENE-070705-554
• Length: 2633
• Species: Danio rerio
• Alignment Length: 2797
• Identity: 536/2797 - (19%)
• Similarity: 959/2797 - (34%)
• Gaps: 708/2797 - (25%)

  Fly    49 YDYSFDSILTIGASSDVPNDSDDTSLKVSGSAK-IFAKGNCGYTLQLSSVKVTNT-------KES 105
            |.|..:|:.::....:.|..|....:.|..::| |....:|    :||.|...:|       |.:
Zfish    31 YFYETESLNSLNKQVNGPKASCRVEILVPDASKYILRTTDC----KLSEVTAVDTEGNPVFGKAA 91

  Fly   106 VEKKILNSIQK-PVQFTLVSGILEPQICSDSSDLDYSLNIKRAVVSLLQSGIEAE----HEVDVF 165
            ..:.....::| |::||:..|  |.::..:..:....|||||.::|.|...:..|    :...::
Zfish    92 AAEDFRTDMEKNPLKFTVTKG--EIRLFPEKGERANILNIKRGIISALAVPLLEEDRKKNTPSIY 154

  Fly   166 GMCPTHTSTSKVGNANIITKARNLNSCSHREQINSGLVSGKVNEKAGITSSLLLQANYIKESRIV 230
            |:|.|..:   |..|..:|..|:|:.|.....|...            ||.|.|....   |..:
Zfish   155 GLCMTEYT---VDTATAVTLNRDLSRCDKFRPIEDH------------TSPLALITGL---SHPL 201

  Fly   231 NHLIENVQLTETYKFIGNTKRNSDISAKVVTILKLKNPSGTKA--NSPGTGSTVRSL--IFQRPE 291
            ..||.:.| |..|||   .|....:::.:.|...:..|...|.  ....||..|.:|  :.:..:
Zfish   202 AQLIRSNQ-TCNYKF---DKEQEHMTSAICTEKHVLVPFSHKGEYGVTNTGKQVLTLLGVTENND 262

  Fly   292 TYTSKNINALK--------------------TILSDLVDSTGDYVKKETAKKFVEFIRLLRQSDS 336
            .....||..:|                    .:|.:|.|.......::.|....:.:.::|:.::
Zfish   263 RVFDHNIANMKPLHLDRSVDISPVQDKEAALAVLRELADLYKTNSGRKRAHLAYKLVAVIRKMEA 327

  Fly   337 ETLLELAAFPHPNKVLARKVYLDGLFRTSTAESARVILKQLSKFDEK--EKLLAILSLNIVKSVD 399
            |||  .||.|....: :|.:....|.:..|.:.:..|::.:..||:.  |...|:.::.|:....
Zfish   328 ETL--RAALPEALGI-SRSLTYQALLQCGTPKCSSAIMQIIRTFDKSSFEVDAAVYAIGIIPQTS 389

  Fly   400 ----KETLNQAASQLLPNAPKELYIAVGNLVAKYCLKNYCQGPEIDAISKKFSDGLKHCKPNTKR 460
                ||.|  |.:::.|:.|  :|.|:.|.|.:....:.... ||.|::....:.:..|    ..
Zfish   390 QVLVKEML--ATAKIKPSRP--IYYALSNAVRRLYETDGVTS-EIQAVADYALEQIGDC----TG 445

  Fly   461 EEERIVYILKGLGNAKSLSGNTVAALS----ECAS-TGRSNRIRVAALHAFSKVKCEETLQSKSL 520
            ::|.:...||.:||..:..|....||.    :|.: .|.|..::.||:..:.:....|..:...:
Zfish   446 DQEHVFLSLKVIGNMVAALGAARPALHSAVIKCINQPGASPAVQQAAIQVYRQFPVPEEGREVLM 510

  Fly   521 ELLKNRNEDSELRIEAYLSAISCPN-AEVANQISEIVNSETVNQVGGFISSNLKAIRDSTDVSRD 584
            ..:.::....:.|:.|||..:..|. ||:| |::..:..|..::...||.|::.:|..||.....
Zfish   511 HTVLDKVASVQKRVAAYLILMKNPTPAELA-QLAAALEIEKNHEAKSFIISHISSIMASTAPETL 574

  Fly   585 QQKYHLANIRVTKTFPVDYRRYSFNNEVSYKLESLGVGASTDYQIIYSQHGFLPRSSRINVTTEF 649
            ..:.::.|........:..:...|:..  |:|.||      :...|:.....|||...:.:|...
Zfish   575 NLRQNIQNAFQGNDIEMAMKSTQFSRH--YRLGSL------EGNFIFESPDNLPREVMLEMTLNA 631

  Fly   650 FGTNYNVFEASVRQENVEDVLEYYLGPKGLVNKDFDEIV-------------KLIEVGNNGVAAG 701
            ||.:.::.|..:..:..|.:||...|..|.    |.:||             :|.||.:|.:...
Zfish   632 FGLDMDLIEIGMEGKGFEPILEALFGEDGF----FPDIVMKSILYATDKMPAELNEVWDNMLPNL 692

  Fly   702 GRAR----------RSIVDDVSKISKKYKMYGVKNVQDLNLDVSLKLFGSELAFLSLGDNIPSSL 756
            ...|          :.|.|.|:|:|:..|........     |.|||.|:||.:|...|.  ..:
Zfish   693 NNYRKKRQATQNIVKEISDSVNKLSEDLKAQDAPEAM-----VYLKLLGAELGYLDAKDG--KMI 750

  Fly   757 DDIINYFSTSFEKAKQELSSFEKQFSSHHLFLDTDLAYPTSIGVPLELVAQGFAATKVDLAVSLD 821
            ..::....|.|  .|:..||.:.:...|::|:|.:...||:.|.||.:...|
Zfish   751 GSLLKMIPTDF--TKRLFSSVDNELFLHYIFMDNEFYLPTAAGFPLRVALSG------------- 800

  Fly   822 INAILEQNWQKAKYRLKFVPSV--DINANVQIGFNAQVLSTGLRVVSS--------AHSAT---- 872
                            .|.|.:  .::.|..:|..|.:||.|:.:|:.        .||..
Zfish   801 ----------------TFTPGIKGGLSFNPGMGDFAFMLSAGVELVTEIGTHLPDYVHSGLEMHT 849

  Fly   873 ----GSDITVAVISDGEGFNVDLELPREKLELINFNVDTELYVAEQDKQKAIALKGNKKNKNSQP 933
                .|.:...:....:...:.:..|||..|||:..            ...:::.|.|....|
Zfish   850 NIYHESGLRAKISGTQKRLKLSIPAPREPTELISVT------------NSLVSVVGGKILPIS-- 900

  Fly   934 SEICFNQLELVGLNICIKSSTSLSEVQAG-NGNVAERGLSVSEKFHLS-RPFNFAVYLTTERKFT 996
            :.:.:...:...:...:||.|:|....|. |.|.....|:...:|.:. ||.......|....:|
Zfish   901 ANVQYTMEDCTAVFPGLKSCTTLEYPDAALNDNAPYFPLTGDSRFAVEIRPSGTVTEYTAIIGYT 965

  Fly   997 FKGIHTQEAFSQKWKLDYSTPGSKVSHDTTVVYELGNKPKTFS-RLSFDNSQCHFAVEGGINND- 1059
            ::        .::.||.:|........:......:..|..|.| :|..:..|....|.|...|.
Zfish   966 YE--------DEEDKLTFSVKAEGTPFEVLNTVMINRKLNTASMKLLMEALQLDHTVSGKFTNAE 1022

  Fly  1060 ------KNELVVYG---------QYEQDKEIKKSKIGFSKNGNEYKPLIEIQDNNGISNSINGYH 1109
                  :::|.:.|         .||.:|...:.|..|:.......||....|.
Zfish  1023 KLKLELQSDLKLPGTTSVQTLILTYESEKIEAEVKSHFNSKTRTLVPLFRTGDT----------- 1076

  Fly  1110 ADGKIVVKKNSNNIERYNFENFQVSNSNNAHVAVNGWSDVGTNSLTSELRISLD----------H 1164
                |::...:..:.:...:...:.....|...|....|:   :|..||.:::|          :
Zfish  1077 ----IIIGLLTRQMGQNKIKLLDIIAKLAAFSGVPATLDI---TLPEELFLNIDAAVKYHFGQPY 1134

  Fly  1165 QTFLI--------KENLKLENGLYEAGFFINDE---------HSPENIYGSSIHLTIADQSYALK 1212
            .|..:        ..:||....|....|.::.:         ..||::..|.....:||.|
Zfish  1135 YTITLPLPLGGKSTRDLKFPTTLSTDLFIVDPDLESMQLPEVSIPESVTLSLHAFQLADVS---- 1195

  Fly  1213 TNGKAAAWSIGSDGSFNFQKLADSNSARAGSL-------VENVEIQYKNKQVGGIKIMSNFDVNK 1270
              ||........|.:.:..:...::|:.:..|       ||...:     ||.|..:......:.
Zfish  1196 --GKLRCHLYDLDATVSAARDPAAHSSYSAKLKVTGTSPVEQFCL-----QVEGSALAEATSGDS 1253

  Fly  1271 MDVDVEISREQKIGSIIVKYESNQRHAQDYSLEASAKINKHSIDVISKCDFNGNVYVVDNSLVTS 1335
            :...::...|.|..:..:..|...:.|...|:::.:|:...|: |..:.....|...
Zfish  1254 LKASMKTVIEHKFFNATISVEEEVQSAAKLSVKSKSKLEVTSL-VAEQMSVEHNAIF-------- 1309

  Fly  1336 WGTLLSAKGEIGQRYSAQDININIQGNVQ-------ISGKDKVTQWILKVIGTPDKTNSDFRISR 1393
                   :|:.||        |:..||::       |.|...:.|.:|.:   |.|..:..
Zfish  1310 -------EGDAGQ--------ISGDGNLEGSFKAGSIYGSGNLKQSVLLI---PSKQEAKI---- 1352

  Fly  1394 DTSELIKLTSESQHPQD--KISFAKLNLIVKNQLTAKGEF-----RVAKN----GKGDFT----- 1442
              ..|:|:.|:....|:  .::||...|.|.:..||..:.     :||.|    |...:|
Zfish  1353 --DSLLKVDSKLLQAQNSFSVAFANRELTVLSTTTAFDDILTNTAKVAINESQIGLSYYTKAQGF 1415

  Fly  1443 -------------ASIDTLKTEPKHKLEIESKFHIQSPKYDI-------DASLTLDGKRKVH--- 1484
                         |...::|.|....|..|..:.|.:.:.||       |||..|.|.|..|
Zfish  1416 GLKIENTAETRADAKAISVKIETSGDLSQERIYSIVTGELDINGLAIKSDASAKLMGHRAAHNAI 1480

  Fly  1485 ----------------------LKSENTIE----------KLKFSTKNIGEANDKIIAFEANGSL 1517
                                  .|.:||.|          :.|.:.|.||.:.|.....:.||.|
Zfish  1481 LNFNKDGLTSSGTTTLQSILSQEKVKNTFEVIYKKLTANLQCKTNGKFIGASIDHNTEMKINGLL 1545

  Fly  1518 KGELRGNGEIQGTFIFNA--------PDGRVIDGSINRKISTNAKSGL-SQG------NIDAQLS 1567
                   |.|:....||:        ..|..:..|.|...:.|....: ::|      |....|.
Zfish  1546 -------GRIENILRFNSRILNVETNTRGTTVPFSFNFNFAANGSENVYNRGHYREDFNTKMHLK 1603

  Fly  1568 DTPFG---SNKKRSISLIGKLDRLNTKTK-EFSANSNLVYTAFNGEKSEISYQIKQQPNGDAKNI 1628
            ..|..   |::.:..:|:........:.: ||.:.|.|:   .|..:.:....:|.:.|..|  |
Zfish  1604 IDPESITHSHECKISTLVETYGFYGVEVESEFQSKSELL---LNPSEQKAKMAVKVKVNKHA--I 1663

  Fly  1629 DFSLKAYGNPLPQPFEIAFALGDYSAQHAVVSITSKYGEIFSVSANGNYNNNQAL---------E 1684
            :..:.||..|.....|     |.......:::......:.|:|||...|:.|..:         .
Zfish  1664 NQEINAYNTPAQFGLE-----GSGKVFTNLLNTADDDHQDFAVSAFLKYDKNNQMHSIYLPFVDS 1723

  Fly  1685 YGLQANIEIPKS----------TLKSLEINSHGKVLKSLIGNENAAYNVEFFLDSKTS------- 1732
            .||     :|.|          ||..|...|..|.:.:.:.|.|.....|.|..:..:
Zfish  1724 LGL-----VPSSVILTYSSIEETLAYLAYLSLPKHVSNFVSNMNFGRRAEQFQRASIALYQEYPL 1783

  Fly  1733 -LGQYARVNTVWNGTANDGSYDFEAQTNN----------------------------MESPLKFN 1768
             ||.|.:..:.......:...:|:..|.|                            :.|.||..
Zfish  1784 KLGVYEKQLSDMISQITEALSNFKQLTANGMLIENVDRMLTKHINALMFLITEDVKLLLSLLKPQ 1848

  Fly  1769 G-----------KYH----RKQTGNIKDGDLTGKQTYVLNAQYGAQYVKMDA----------SLG 1808
            |           .|.    .|..|.|:    .....|.||.  .|::..:.|          |.|
Zfish  1849 GHTKLQIPASTKSYQLPCFEKMHGEIR----FTSPVYSLNT--SAEFKNVSATHPQFAGVIKSKG 1907

  Fly  1809 YGAE----KVDIAYVIDSSFDSVKDIKVN-----IRTFKPLDDSTYVV--TALFKQTD-KSYGLD 1861
            ..|.    ..:|.|.:..|...:..:.|:     ..::..||.|..:.  .::.|..| .|..||
Zfish  1908 ISASLEVLNYNIDYTMQISIPEMTPVSVSETLKITHSYLTLDQSASLTLNASITKGPDFSSLSLD 1972

  Fly  1862 TTFYHSAHKKGVDIRLDLLKEKPIIISSIAELLGDRKGKVLFEILN-------LADLDIKINSEA 1919
            |::     |..|:|.|..|..: :.::|.|..:......|:.::||       |.|    .:.|.
Zfish  1973 TSY-----KNQVNIPLHSLSSE-VTLASKAVAVYQNNAAVILKVLNTGIGKFTLED----FSDEG 2027

  Fly  1920 SYVSIDEFYIIVNWSSKKLKLDGY--------ELEARAQSKNIKIQLKNENGIIFSGTATYALKK 1976
            ::.|  :....:..|:.||:|.|:        |:.....:..:.:.....|  :|:.|.:..:||
Zfish  2028 THDS--DLLFTMGLSAAKLRLKGHTDSSALQMEMNVDVDADAVALSYLKFN--VFAETKSPFIKK 2088

  Fly  1977 ELNKTIIDGQGKVQYQGKALSGNFKLTRQHFDFGT--------------DREVGFSYTFMGNLGS 2027
              |..:..|...:......:|||.:   ..|| |.              .||:...:...||  :
Zfish  2089 --NLLVASGNVSINDMDVKISGNHE---TEFD-GVVSVVLSNTASVIICPREIAVEFQNKGN--A 2145

  Fly  2028 KNGLGTLKITNKEFNTKFSVCEEKRQCTNLIVQSIVSIDEQKLDAVEHTTLIIVDLRDFGYPYEF 2092
            |..|....||:.:....::|          ||.|         |..|.:|:.:..:..  |.|..
Zfish  2146 KTDLYEFLITSVDLQNDYTV----------IVNS---------DLQEVSTIAVAQINH--YKYSH 2189

  Fly  2093 ELKSQNTRQGLKYQYHLDSFIITGNN-------FK--------------YQFTANVQPTSSTIKL 2136
            .|.:.|....:.....::||.|..|.       ||              :.||.|.|.|....||
Zfish  2190 NLTANNNNAEIGVYAGVNSFGILNNAVQFVPFVFKKAVVEYLKDESGIWHDFTTNNQATDLNAKL 2254

  Fly  2137 ALPKRQILFETTQ----KIPADGSLFGRYEQTASFFIDKLQK-----PDDVARFSAIVDVTGTER 2192
            ...|...:...:.    .:|:.|:|......|:|  |..|..     |||.     ::.::||..
Zfish  2255 VYQKTTTVLGDSDGLAVVVPSLGNLVSEVSSTSS--ILNLNANAGVYPDDY-----LMRISGTAT 2312

  Fly  2193 VAFNANGKLKFEHPTIRPLSISGQLNGDVNQQIASAEVIFDIFRLPEQKVVGNSELRNSRSQNGF 2257
            .||. ..:.|....||        :..:...::||...:       :...:|.:...:...|:.:
Zfish  2313 SAFQ-QLRAKLYGATI--------ITTESGLKLASTLFL-------DNSQIGGTHNSSVTLQDNY 2361

  Fly  2258 NIAYIT-TVKSAGLQ-FQYQINSNAAVDIEAHEYNIGLELNNGEIDVKAISFLNKEKFEISLSES 2320
            .:..:: |:....|. |..:.:...:.|.:.|              :||:|.| |.|:.....:|
Zfish  2362 EVVLVSDTIAKINLTIFSIEADHQLSADTKTH--------------LKALSNL-KIKYSFDHPDS 2411

  Fly  2321 NKHIIYIVGDFS---KQNHYAKLNTKVQILDKNPIEITSEVQPNSAKI---ILKRQDFIDGTAEV 2379
            ...     ||..   |.|.|         |....:|.||:|..||...   .||  ..:|..|.:
Zfish  2412 RGG-----GDAENTLKMNAY---------LSSITVESTSQVTTNSTLPDGGALK--GTLDSDANI 2460

  Fly  2380 KL---GKEFKVDVIGSGKQLF-NGRVALDATNFLQTNYFINEDHLNGFWHIVESEINKDSEYISE 2440
            .:   |.:..|....:|...: |.:::.|     ..:..|.|.:.|...::::.:.|...:|..|
Zfish  2461 SVNVAGLKSNVKASANGYYDYRNNKLSFD-----MNDQVILEGNFNRIHYLLDIDSNYTHKYRRE 2520

  Fly  2441 NI 2442
            .:
Zfish  2521 EV 2522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
apolpp	NP_001259085.1	Vitellogenin_N	43..573	CDD:279663	122/572 (21%)
		DUF1943	605..911	CDD:286281	73/346 (21%)
		DUF1081	932..1031	CDD:283982	16/100 (16%)
		VWD	2789..2931	CDD:214566
apobb.2	XP_002665852.3	Vitellogenin_N	23..535	CDD:279663	113/543 (21%)
		DUF1943	597..889	CDD:286281	73/353 (21%)
		DUF1081	908..1001	CDD:283982	18/100 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9082
eggNOG	1	0.900	-	-		E1_KOG4338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	184	1.000	Inparanoid score	I3938
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6550
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950