DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and INHBE

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_113667.1	Gene:	INHBE / 83729	HGNCID:	24029	Length:	350	Species:	Homo sapiens

Alignment Length:	341	Identity:	90/341 - (26%)
Similarity:	122/341 - (35%)	Gaps:	112/341 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   639 GNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQIHIRIDKPHS-------LWIEKA 696
            ||.:|:|:||                    ..:...|..|:.:...:..|.|       ||:...
Human    87 GNGEEVISFA--------------------TVTDSTSAYSSLLTFHLSTPRSHHLYHARLWLHVL 131

  Fly   697 KSLPEKHLLNTKRKWGANK----------PHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVD 751
            .:||....|...| ||..:          .||              ||
Human   132 PTLPGTLCLRIFR-WGPRRRRQGSRTLLAEHH--------------IT----------------- 164

  Fly   752 PKNLGWQKFDLTDT-IREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSDYLSTNPNR 815
              ||||....|..: :|   |..| ..|:|.:||              ..|.|||:  ::..|.|
Human   165 --NLGWHTLTLPSSGLR---GEKS-GVLKLQLDC--------------RPLEGNST--VTGQPRR 207

  Fly   816 ---------PFLVLHTESSR--TRRVRRRAVDCGGALNGQCCKESFYVSFKALGWDDWIIAPRGY 869
                     |||.|...::.  ..|.|||...|..| ...||:...||.|:.|||.|||:.|.||
Human   208 LLDTAGHQQPFLELKIRANEPGAGRARRRTPTCEPA-TPLCCRRDHYVDFQELGWRDWILQPEGY 271

  Fly   870 FANYCRGDC----TGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDG- 929
            ..|||.|.|    .||   |....:||:......:..........||.|.....:||:|...:|
Human   272 QLNYCSGQCPPHLAGS---PGIAASFHSAVFSLLKANNPWPASTSCCVPTARRPLSLLYLDHNGN 333

  Fly   930 IIKRDLPKMVVDECGC 945
            ::|.|:|.|||:.|||
Human   334 VVKTDVPDMVVEACGC 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	38/106 (36%)
INHBE	NP_113667.1	TGF_beta	247..349	CDD:306518	38/104 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5953
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1385831at2759
OrthoFinder	1	1.000	-	-		FOG0000887
OrthoInspector	1	1.000	-	-		otm40920
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X477
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.880