Protein Alignment Actbeta and GDF5

DIOPT Version :9

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_000548.2
• Gene: GDF5 / 8200
• HGNCID: 4220
• Length: 501
• Species: Homo sapiens
• Alignment Length: 377
• Identity: 92/377 - (24%)
• Similarity: 141/377 - (37%)
• Gaps: 95/377 - (25%)

  Fly   600 GRSSIGYQPAIHN-IEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFS 663
            |.||:..:..:.| |.....||.     ||...:..:..:  ..:|....::|....:.|||...
Human   188 GNSSVKLEAGLANTITSFIDKGQ-----DDRGPVVRKQRY--VFDISALEKDGLLGAELRILRKK 245

  Fly   664 AQNRRVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKH----LLNTKRKWGANKPHHRI-KIW 723
            ..:...|:.....|:||:             |..|.|...    ||:.:...|.:.....: .||
Human   246 PSDTAKPAAPGGGRAAQL-------------KLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIW 297

  Fly   724 VF--------QLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRL 780
            ..        ||...:...|:|       ||   ||.:.||:.:          .....|||...
Human   298 KLFRNFKNSAQLCLELEAWERG-------RA---VDLRGLGFDR----------AARQVHEKALF 342

  Fly   781 LIDCTGCGGRYSLH--LFQTSKLRGNSSD-----YLSTNPNRPFLVLHTESSRTRRVRRRAVDCG 838
            |:     .||....  .|...|.|....|     ||.:...:....|     .||:.:|.:.:
Human   343 LV-----FGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPL-----ATRQGKRPSKN-- 395

  Fly   839 GALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRT---PDTFQTFHAHFIEEYR 900
              |..:|.:::.:|:||.:|||||||||..|.|.:|.|.|....|:   |    |.||..
Human   396 --LKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEP----TNHAVI----- 449

  Fly   901 KMGLMNGMRP------CCAPIKFSSMSLIYYGD-DGIIKRDLPKMVVDECGC 945
             ..|||.|.|      ||.|.:.|.:|:::... :.::.:....|||:.|||
Human   450 -QTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGC 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
		TGF_beta	843..945	CDD:278448	37/111 (33%)
GDF5	NP_000548.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..169
		TGFb_propeptide	145..344	CDD:279078	39/195 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..265		4/31 (13%)
		TGFB	400..501	CDD:214556	39/111 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810