DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and ndr1

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_571041.1	Gene:	ndr1 / 799352	ZFINID:	ZDB-GENE-990415-256	Length:	392	Species:	Danio rerio

Alignment Length:	371	Identity:	80/371 - (21%)
Similarity:	140/371 - (37%)	Gaps:	102/371 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   628 DHENIDHEDFFGNTQEIITFAEEGTQYRQYRILEFSAQNRRVPSQKLS-------------IRSA 679
            |.::..||:              .|.|....:|...|::......|.:             ::.|
Zfish    70 DEKHFSHEN--------------PTLYESDSVLSLVAKSCHQVGDKFAVTFDMSSISASDDVQRA 120

  Fly   680 QIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTS-INITEKGIDKAII 743
            ::.||:  ||      .:|..|..:.:.........|...:::.:..|:.: ||.|
Zfish   121 ELRIRL--PH------LRSELEVDIYHASTPECERSPCEEVRVHLGTLNANPINST--------- 168

  Fly   744 FRASFQVDPKNLGWQKFDLTDTIREWYGHTSHEKLRLLID-----CTGCGGRYSLH--------- 794
            ||:|         |:.|::|..::.|.    |:..|:..:     .....|..|:|
Zfish   169 FRSS---------WRIFNITALLKYWL----HQSERVPFEEPTQMPPMAEGHKSVHHPTANRVMM 220

  Fly   795 LFQTSKLRGNSSDYLSTNPNRPFLVL-------------HTESSRT-RRVRRRAVDC-------G 838
            :..:.:.|..:|..:.|..:..::.|             |..:.|| .|||..|...       |
Zfish   221 VVYSKQNRAKTSTLIRTAEHSKYVALDRAGGGSEPVPRRHRRNHRTDDRVRDAAAGMIPGVSHEG 285

  Fly   839 GALNGQCCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTP--DTFQTFHAHFIEEYRK 901
            |.....|.|...:|.|..:||.|||:.|:.|.|..|.|.|.    ||  :||...:..:::...|
Zfish   286 GEKKPLCKKVDMWVDFDQIGWSDWIVYPKRYNAYRCEGSCP----TPVDETFTPTNHAYMQSLLK 346

  Fly   902 MGLMNGMRPC--CAPIKFSSMSLIYYGDDGIIKRDLPKMVVDECGC 945
            :...:.: ||  |.|.:.:.:|::||.:..::.|....|||.||||
Zfish   347 LHHPDRV-PCLSCVPTRLAPLSMLYYENGKMVMRHHEGMVVAECGC 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	33/105 (31%)
ndr1	NP_571041.1	TGFb_propeptide	56..190	CDD:279078	28/163 (17%)
ndr1	NP_571041.1	TGF_beta	291..391	CDD:278448	33/104 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810