DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Actbeta and mstnb

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_571094.2	Gene:	mstnb / 798441	ZFINID:	ZDB-GENE-990415-165	Length:	374	Species:	Danio rerio

Alignment Length:	347	Identity:	85/347 - (24%)
Similarity:	139/347 - (40%)	Gaps:	91/347 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 HESFADDHEN--IDHEDFFGNTQEIITFAEEGTQYRQYR------ILEFSAQ---NRRVPSQKLS 675
            ::...||.::  ::.:|....|:.|:|.|.|.....|..      ...||.:   ||.|.:|
Zfish    95 YDVLGDDSKDGAVEEDDEHATTETIMTMATEPDPIVQVDRKPKCCFFSFSPKIQANRIVRAQ--- 156

  Fly   676 IRSAQIHIR-IDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGID 739
               ..:|:| .::..:::::.::.:|.|           :...|||:
Zfish   157 ---LWVHLRPAEEATTVFLQISRLMPVK-----------DGGRHRIR------------------ 189

  Fly   740 KAIIFRASFQVDPKNLG---WQKFDLTDTIREWYGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKL 801
                   |.::| .|.|   ||..|:...:..|.....          |..|...:.:     ..
Zfish   190 -------SLKID-VNAGVTSWQSIDVKQVLTVWLKQPE----------TNRGIEINAY-----DA 231

  Fly   802 RGNSSDYLSTNPNR----PFLVLHTESSRTRRVRR-RAVDCG-GALNGQCCKESFYVSFKALGWD 860
            :||.....||....    ||:.:.. |...:|:|| ..:||. .:...:||:....|.|:..||
Zfish   232 KGNDLAVTSTETGEDGLLPFMEVKI-SEGPKRIRRDSGLDCDENSSESRCCRYPLTVDFEDFGW- 294

  Fly   861 DWIIAPRGYFANYCRGDCTGSFRTPDTFQTF-HAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIY 924
            ||||||:.|.||||.|:|...:     .|.: |.|.:.:....|...   |||.|.|.|.::::|
Zfish   295 DWIIAPKRYKANYCSGECDYMY-----LQKYPHTHLVNKASPRGTAG---PCCTPTKMSPINMLY 351

  Fly   925 Y-GDDGIIKRDLPKMVVDECGC 945
            : |.:.||...:|.||||.|||
Zfish   352 FNGKEQIIYGKIPSMVVDRCGC 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	39/103 (38%)
mstnb	NP_571094.2	TGFb_propeptide	38..252	CDD:279078	37/214 (17%)
mstnb	NP_571094.2	TGFB	280..374	CDD:214556	41/103 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810