Protein Alignment Actbeta and TGFB3

DIOPT Version :9

• Sequence 1: NP_651942.2
• Gene: Actbeta / 43826
• FlyBaseID: FBgn0024913
• Length: 946
• Species: Drosophila melanogaster
• Sequence 2: NP_001316868.1
• Gene: TGFB3 / 7043
• HGNCID: 11769
• Length: 412
• Species: Homo sapiens
• Alignment Length: 462
• Identity: 106/462 - (22%)
• Similarity: 164/462 - (35%)
• Gaps: 126/462 - (27%)

  Fly   530 LKSGAVRK--VNGINGTQMNENALKKSTYPIDINH------SIDNKTHTGKNGEMSHNDYEYFND 586
            |..|.::|  |..|.|..:::..|.....|..:.|      ::.|.|.  :..|..|.:.|   :
Human    30 LDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHVPYQVLALYNSTR--ELLEEMHGERE---E 89

  Fly   587 YSVQTHDKNRYHEGRSSIGYQPAIHNIEYENQKGHHESFADDHENIDHEDFFGNTQEIITFAEEG 651
            ...|.:.::.|        |...||..:.......|...|...:.|..:.|..|...:
Human    90 GCTQENTESEY--------YAKEIHKFDMIQGLAEHNELAVCPKGITSKVFRFNVSSV------- 139

  Fly   652 TQYRQYRILEFSAQNR--RVPSQKLSIRSAQIHIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGAN 714
               .:.|...|.|:.|  |||:.. |.|:.|   ||:....|       .|::|:...:...|.|
Human   140 ---EKNRTNLFRAEFRVLRVPNPS-SKRNEQ---RIELFQIL-------RPDEHIAKQRYIGGKN 190

  Fly   715 KPHHRIKIWVFQLSTSINITEKGIDKAIIFRASFQVDPKNLGWQKFDLTDTIREW-YGHTSHEKL 778
            .|                  .:|..:                |..||:|||:||| ....|:..|
Human   191 LP------------------TRGTAE----------------WLSFDVTDTVREWLLRRESNLGL 221

  Fly   779 RLLIDCTGCGGRYSLHLFQTS-------------KLRG--NSSDY---------LSTNPNRPFLV 819
            .:.|.|. |      |.||.:             |.:|  |..|:         ...:.:.|.|:
Human   222 EISIHCP-C------HTFQPNGDILENIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLI 279

  Fly   820 L-----H--TESSRTRRVRRRAVD---CGGALNGQCCKESFYVSFKA-LGWDDWIIAPRGYFANY 873
            |     |  ....:..:.::||:|   |...|...||....|:.|:. ||| .|:..|:||:||:
Human   280 LMMIPPHRLDNPGQGGQRKKRALDTNYCFRNLEENCCVRPLYIDFRQDLGW-KWVHEPKGYYANF 343

  Fly   874 CRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLMNGMRPCCAPIKFSSMSLIYYGDDGIIKRDLPKM 938
            |.|.|. ..|:.|   |.|:..:..|..:.......|||.|.....::::||.........|..|
Human   344 CSGPCP-YLRSAD---TTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNM 404

  Fly   939 VVDECGC 945
            ||..|.|
Human   405 VVKSCKC 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
		TGF_beta	843..945	CDD:278448	32/102 (31%)
TGFB3	NP_001316868.1	TGFb_propeptide	24..230	CDD:395559	57/274 (21%)
		Cell attachment site. /evidence=ECO:0000250|UniProtKB:P01137	261..263		0/1 (0%)
		TGF_beta_TGFB3	312..412	CDD:381656	33/105 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11848
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910