DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Actbeta and Bmp8a

DIOPT Version :9

Sequence 1:	NP_651942.2	Gene:	Actbeta / 43826	FlyBaseID:	FBgn0024913	Length:	946	Species:	Drosophila melanogaster
Sequence 2:	NP_001102902.1	Gene:	Bmp8a / 680931	RGDID:	1585858	Length:	399	Species:	Rattus norvegicus

Alignment Length:	372	Identity:	85/372 - (22%)
Similarity:	142/372 - (38%)	Gaps:	101/372 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 HESFADDHENIDHEDFFGNTQEIITFA-----EEGTQYRQYRILEFSAQNRRVPSQKLSIRSAQI 681
            :.:..||.:....:...|....:::|.     :....|::....||.....::|:.: ::.:|:.
  Rat    80 YHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGE-AVTAAEF 143

  Fly   682 HIRIDKPHSLWIEKAKSLPEKHLLNTKRKWGANKPHHRIKIWVFQLSTSINITEKGIDKAIIFRA 746
            .|..:             |..|           .|:..:.|.:|::     :.|:...::.:|..
  Rat   144 RIYKE-------------PSTH-----------PPNTTLHISMFEV-----VQERSNRESDLFFL 179

  Fly   747 SFQ-VDPKNLGWQKFDLTDTIREW-YGHTSHEKLRLLIDCTGCGGRYSLHLFQTSKLRGNSSD-- 807
            ..| :...:.||...|:|.....| ..|.....|||.::...                |:|.|
  Rat   180 DLQTLRSGDEGWLVLDITAASDRWLLNHNKDLGLRLYVETED----------------GHSLDPG 228

  Fly   808 ------YLSTNPNRPFLVLHTESS----RT----RRVRRR----------------AVDCGGALN 842
                  ..:....:||:|....:|    ||    |.::||                ..|.|....
  Rat   229 LAGLLGQTAPRSRQPFMVTFFRASSSPVRTPRAVRPLKRRQPKKTNELPHPNKLPGIFDDGHGSR 293

  Fly   843 GQ--CCKESFYVSFKALGWDDWIIAPRGYFANYCRGDCTGSFRTPDTFQTFHAHFIEEYRKMGLM 905
            |:  |.:...||||:.|||.||:|||:||.|.||.|:|....   |:......|.|.:    .|:
  Rat   294 GREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFPL---DSCMNATNHAILQ----SLV 351

  Fly   906 NGMRP------CCAPIKFSSMSLIYY-GDDGIIKRDLPKMVVDECGC 945
            :.|:|      ||||.|.|:.|::|| ..:.:|.|....|||..|||
  Rat   352 HLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGC 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Actbeta	NP_651942.2	TGFb_propeptide	370..>509	CDD:279078
Actbeta	NP_651942.2	TGF_beta	843..945	CDD:278448	42/110 (38%)
Bmp8a	NP_001102902.1	TGFb_propeptide	32..248	CDD:279078	33/213 (15%)
Bmp8a	NP_001102902.1	TGF_beta	298..398	CDD:278448	41/106 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3900
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810